Role and potential for therapeutic targeting of MYB in leukemia (Q38033019)

27 August 2017

title

Role and potential for therapeutic targeting of MYB in leukemia (English)

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27 August 2017

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D R Pattabiraman

1

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27 August 2017

T J Gonda

series ordinal

2

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27 August 2017

publication date

9 August 2012

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27 August 2017

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27 August 2017

volume

27

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27 August 2017

issue

2

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27 August 2017

page(s)

269-277

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Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The myb gene family in cell growth, differentiation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Viral myb oncogene encodes a sequence-specific DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Protein truncation is required for the activation of the c-myb proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Oncogenic activation of c-Myb by carboxyl-terminal truncation leads to decreased proteolysis by the ubiquitin-26S proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Differential expression of the amv gene in human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

MYB function in normal and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb is essential for early T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb regulates the proliferation of immature thymocytes following beta-selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Coordination of erythropoiesis by the transcription factor c-Myb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb is critical for B cell development and maintenance of follicular B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

A recessive screen for genes regulating hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Myeloid and erythroid neoplastic responses to avian defective leukemia viruses in chickens and in quail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Transformation of both erythroid and myeloid cells by E26, an avian leukemia virus that contains the myb gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Two modes of c-myb activation in virus-induced mouse myeloid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Truncated c-Myb expression in the human leukemia cell line TK-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Alu elements mediate MYB gene tandem duplication in human T-ALL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Molecular genetics of acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Genetics of myeloid leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Molecular genetics of human leukemias: new insights into therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The molecular biology of mixed lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Identification and characterization of Hoxa9 binding sites in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

RNAi therapeutics: principles, prospects and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

FLT3 as a therapeutic target in AML: still challenging after all these years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Myb binding proteins: regulators and cohorts in transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-Myc is essential but not sufficient for c-Myb-mediated block of granulocytic differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Pim-1 kinase and p100 cooperate to enhance c-Myb activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Differential expression of the oncoproteins c-myc and c-myb in human lymphoproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

c-myb gene analysis in T-cell malignancies with del(6q).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Characterization of a rearrangement in the c-MYB promoter in the acute lymphoblastic leukemia cell line CCRF-CEM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

CBP as a transcriptional coactivator of c-Myb

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Activation of c-myb by carboxy-terminal truncation: relationship to transformation of murine haemopoietic cells in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Activation of cMGF expression is a critical step in avian myeloid leukemogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

In vivo expression of an aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Microsatellite deletions in the c-myb transcriptional attenuator region associated with over-expression in colon tumour cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Protein-protein interaction inhibitors get into the groove

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

myb oncogene in human hematopoietic neoplasia with 6q- anomaly

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.225

7 January 2021

Identifiers

DOI

10.1038/LEU.2012.225

1 reference

Dimensions Publication ID

27 August 2017

1047289559

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1 reference