A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks (Q38046131)

27 August 2017

title

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks (English)

1 reference

27 August 2017

Yu Cao

1

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27 August 2017

Lingqiang Zhang

series ordinal

2

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27 August 2017

publication date

25 September 2012

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Cellular and Molecular Life Sciences

27 August 2017

published in

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27 August 2017

volume

70

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27 August 2017

issue

13

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27 August 2017

page(s)

2305-2317

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Narrative review: protein degradation and human diseases: the ubiquitin connection

27 August 2017

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RING domain E3 ubiquitin ligases

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Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

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Animal HECT ubiquitin ligases: evolution and functional implications

21 January 2018

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Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

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NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Itching to end NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of planar cell polarity by Smurf ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Image-based genome-wide siRNA screen identifies selective autophagy factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Protein kinase CK1alphaLS promotes vascular cell proliferation and intimal hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The amplified WWP1 gene is a potential molecular target in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

SMURF1 amplification promotes invasiveness in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Ubiquitin-binding domains - from structures to functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

The cullin-RING ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1170-7

Opposing effects of Arkadia and Smurf on TGFbeta1-induced IgA isotype expression.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23007848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23007848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23007848

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00018-012-1170-7

1 reference

27 August 2017

1 reference