Tankyrases as drug targets (Q38104494)

28 August 2017

Tankyrases as drug targets (English)

1 reference

28 August 2017

1

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28 August 2017

Nai-Wen Chi

2

1 reference

PubMed ID

23648170

28 August 2017

Stefan Krauss

series ordinal

3

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PubMed ID

23648170

28 August 2017

language of work or name

English

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publication date

18 June 2013

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28 August 2017

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28 August 2017

280

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28 August 2017

15

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28 August 2017

3576-3593

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

28 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase promotes telomere elongation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Proteasome regulation by ADP-ribosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The telomeric PARP, tankyrases, as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The ankyrin repeat as molecular architecture for protein recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Ankyrin protein networks in membrane formation and stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Zinc binding catalytic domain of human tankyrase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural basis of selective inhibition of human tankyrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Functional characterization of the poly(ADP-ribose) polymerase activity of tankyrase 1, a potential regulator of telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Telomeric proteins regulate episomal maintenance of Epstein-Barr virus origin of plasmid replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Pharmaceutical regulation of telomerase and its clinical potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Resolution of sister telomere association is required for progression through mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase 1 regulates centrosome function by controlling CPAP stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase function at telomeres, spindle poles, and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Mitotic and mitogenic Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The β-catenin destruction complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Axin: a master scaffold for multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Telomerase subunits expression variation between biopsy samples and cell lines derived from malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Identification of a novel murine pancreatic tumour antigen, which elicits antibody responses in patients with pancreatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Expression of tankyrase 1 in gastric cancer and its correlation with telomerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Telomere-mediated genomic instability and the clinico-pathological parameters in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Expression of TNKS1 is correlated with pathologic grade and Wnt/β-catenin pathway in human astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Herpes simplex virus requires poly(ADP-ribose) polymerase activity for efficient replication and induces extracellular signal-related kinase-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Homogeneous screening assay for human tankyrase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Novel Binding Mode of a Potent and Selective Tankyrase Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Screening and structural analysis of flavones inhibiting tankyrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

PARP inhibitors: polypharmacology versus selective inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Evidence for tankyrases as antineoplastic targets in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

Fragment-based ligand design of novel potent inhibitors of tankyrases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12320

21 January 2018

Identifiers

DOI

10.1111/FEBS.12320

1 reference

28 August 2017

1 reference

PubMed ID

23648170