The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease (Q38111307)

29 August 2017

title

The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease (English)

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29 August 2017

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Hardy J Rideout

1

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29 August 2017

Leonidas Stefanis

series ordinal

2

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29 August 2017

publication date

1 June 2013

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29 August 2017

published in

Neurochemical Research

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29 August 2017

volume

39

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29 August 2017

issue

3

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29 August 2017

page(s)

576-592

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The GTPase function of LRRK2.

29 August 2017

cites work

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12 December 2020

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

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12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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12 December 2020

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

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12 December 2020

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

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12 December 2020

The Roco protein family: a functional perspective

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12 December 2020

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

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12 December 2020

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

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12 December 2020

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

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12 December 2020

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

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12 December 2020

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

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12 December 2020

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

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12 December 2020

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

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12 December 2020

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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12 December 2020

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

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12 December 2020

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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12 December 2020

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations

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12 December 2020

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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12 December 2020

LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP.

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12 December 2020

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models

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12 December 2020

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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12 December 2020

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

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12 December 2020

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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12 December 2020

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

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12 December 2020

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

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12 December 2020

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies

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12 December 2020

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

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12 December 2020

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

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12 December 2020

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

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12 December 2020

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

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12 December 2020

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

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12 December 2020

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

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12 December 2020

Number and brightness analysis of LRRK2 oligomerization in live cells

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12 December 2020

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

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12 December 2020

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

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12 December 2020

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

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12 December 2020

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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12 December 2020

Genome-wide association study reveals genetic risk underlying Parkinson's disease

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12 December 2020

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

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12 December 2020

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

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12 December 2020

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease

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12 December 2020

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

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12 December 2020

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells

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12 December 2020

Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.

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12 December 2020

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

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12 December 2020

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

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12 December 2020

GTPase activity plays a key role in the pathobiology of LRRK2.

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12 December 2020

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

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12 December 2020

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

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12 December 2020

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

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12 December 2020

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

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12 December 2020

Role of mendelian genes in "sporadic" Parkinson's disease

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12 December 2020

LRRK2 regulates synaptic vesicle endocytosis

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12 December 2020

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

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12 December 2020

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

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12 December 2020

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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12 December 2020

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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12 December 2020

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

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12 December 2020

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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12 December 2020

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

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12 December 2020

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

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12 December 2020

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

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12 December 2020

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

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12 December 2020

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

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12 December 2020

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

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12 December 2020

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

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12 December 2020

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

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12 December 2020

Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease

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12 December 2020

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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12 December 2020

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

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12 December 2020

The Parkinson disease gene LRRK2: evolutionary and structural insights

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12 December 2020

Complex I: inhibitors, inhibition and neurodegeneration

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12 December 2020

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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12 December 2020

Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation

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12 December 2020

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway

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12 December 2020

The RIP kinases: crucial integrators of cellular stress

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12 December 2020

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

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12 December 2020

α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

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12 December 2020

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

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12 December 2020

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

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12 December 2020

Mechanism of endophilin N-BAR domain-mediated membrane curvature

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12 December 2020

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

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12 December 2020

Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

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12 December 2020

LRRK2 inhibition attenuates microglial inflammatory responses

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12 December 2020

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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12 December 2020

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

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12 December 2020

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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12 December 2020

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

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12 December 2020

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

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12 December 2020

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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12 December 2020

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

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12 December 2020

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

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12 December 2020

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

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12 December 2020

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

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12 December 2020

LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

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12 December 2020

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

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12 December 2020

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

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12 December 2020

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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12 December 2020

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

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12 December 2020

Kinase activity of mutant LRRK2 mediates neuronal toxicity

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12 December 2020

High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

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12 December 2020

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

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12 December 2020

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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12 December 2020

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

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12 December 2020

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

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12 December 2020

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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12 December 2020

JNK regulates FoxO-dependent autophagy in neurons

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12 December 2020

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

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12 December 2020

Down-regulation of FoxO-dependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells

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12 December 2020

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

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12 December 2020

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

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12 December 2020

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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12 December 2020

LRRK2 Parkinson disease mutations enhance its microtubule association.

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12 December 2020

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

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12 December 2020

Pathological roles of α-synuclein in neurological disorders

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12 December 2020

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

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12 December 2020

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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12 December 2020

Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2.

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12 December 2020

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

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12 December 2020

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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12 December 2020

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

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12 December 2020

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

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12 December 2020

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

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12 December 2020

Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation

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12 December 2020

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

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12 December 2020

LRRK2 I2020T mutation is associated with tau pathology

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12 December 2020

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

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12 December 2020

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

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12 December 2020

LRRK2 expression linked to dopamine-innervated areas

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12 December 2020

A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis

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12 December 2020

Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group

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12 December 2020

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

LRRK2 is involved in the IFN-gamma response and host response to pathogens

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12 December 2020

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

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12 December 2020

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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12 December 2020

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

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12 December 2020

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

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12 December 2020

10.1007/S11064-013-1073-5

Identifiers

DOI

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Dimensions Publication ID

29 August 2017

1028349641

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