Regulatory crosstalk within the mammalian unfolded protein response (Q38153592)

29 August 2017

Regulatory crosstalk within the mammalian unfolded protein response (English)

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29 August 2017

Joseph W Brewer

1

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29 August 2017

18 October 2013

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Cellular and Molecular Life Sciences

29 August 2017

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29 August 2017

71

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29 August 2017

6

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29 August 2017

1067-1079

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https://scigraph.springernature.com/pub.10.1007/s00018-013-1490-2

29 August 2017

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

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The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex

21 January 2018

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response

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Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability

21 January 2018

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ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

21 January 2018

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ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum

21 January 2018

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Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

21 January 2018

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Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish

21 January 2018

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Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

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The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death

21 January 2018

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The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

21 January 2018

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Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions

21 January 2018

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ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

21 January 2018

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Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors

21 January 2018

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

21 January 2018

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Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response

21 January 2018

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Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

21 January 2018

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BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

21 January 2018

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Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.

21 January 2018

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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

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The unfolded protein response signals through high-order assembly of Ire1

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Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

21 January 2018

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

21 January 2018

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Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

21 January 2018

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

21 January 2018

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IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

21 January 2018

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Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

21 January 2018

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

21 January 2018

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Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress

21 January 2018

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

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Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

21 January 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

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Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

21 January 2018

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Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.

21 January 2018

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XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

21 January 2018

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

21 January 2018

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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

21 January 2018

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

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Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.

21 January 2018

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

21 January 2018

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Plasma cell differentiation requires the transcription factor XBP-1

21 January 2018

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The transcription factor XBP-1 is essential for the development and survival of dendritic cells

21 January 2018

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The ER stress transducer IRE1β is required for airway epithelial mucin production

21 January 2018

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Negative feedback by IRE1β optimizes mucin production in goblet cells

21 January 2018

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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

21 January 2018

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IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level

21 January 2018

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PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress

21 January 2018

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

21 January 2018

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Translational control and the unfolded protein response

21 January 2018

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

21 January 2018

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

21 January 2018

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Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

21 January 2018

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gadd153/Chop10, a potential target gene of the transcriptional repressor ATF3.

21 January 2018

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The transcription factor network associated with the amino acid response in mammalian cells

21 January 2018

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Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

21 January 2018

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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

21 January 2018

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Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

21 January 2018

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Activating transcription factor 4.

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Perk is essential for translational regulation and cell survival during the unfolded protein response

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

21 January 2018

1 reference

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

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Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

21 January 2018

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Cell death: critical control points

21 January 2018

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Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

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The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.

21 January 2018

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New directions in ER stress-induced cell death

21 January 2018

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Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat.

21 January 2018

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

21 January 2018

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Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

21 January 2018

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

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JNK signaling in apoptosis

21 January 2018

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IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

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Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

21 January 2018

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Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

21 January 2018

1 reference

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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

21 January 2018

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

21 January 2018

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Modulating stress responses by the UPRosome: a matter of life and death

21 January 2018

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

21 January 2018

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BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

21 January 2018

1 reference

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Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress

21 January 2018

1 reference

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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Divergent effects of PERK and IRE1 signaling on cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

1 reference

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Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.

21 January 2018

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Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation

21 January 2018

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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

21 January 2018

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Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

21 January 2018

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P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

21 January 2018

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Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

21 January 2018

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Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

21 January 2018

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The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

21 January 2018

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Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress

21 January 2018

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A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1490-2

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

21 January 2018

1 reference

12 December 2020

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

1 reference

12 December 2020

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 reference

12 December 2020

An essential role in liver development for transcription factor XBP-1

1 reference

12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

12 December 2020

Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential.

1 reference

12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

12 December 2020

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

1 reference

12 December 2020

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

1 reference

12 December 2020

Membrane phospholipid synthesis and endoplasmic reticulum function

1 reference

12 December 2020

10.1007/S00018-013-1490-2

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

24135849