The aggregation of mutant p53 produces prion-like properties in cancer (Q38186535)

30 August 2017

The aggregation of mutant p53 produces prion-like properties in cancer (English)

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30 August 2017

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4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24509441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Luciana P Rangel

series ordinal

1

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4 June 2020

Danielly C F Costa

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2

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4 June 2020

Tuane C R G Vieira

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3

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4 June 2020

publication date

1 January 2014

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30 August 2017

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4 June 2020

volume

8

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4 June 2020

issue

1

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4 June 2020

page(s)

75-84

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T antigen is bound to a host protein in SY40-transformed cells

4 June 2020

cites work

1 reference

Prion hypothesis: the end of the controversy?

21 January 2018

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

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Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

21 January 2018

1 reference

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant

21 January 2018

1 reference

Fibrillar aggregates of the tumor suppressor p53 core domain

21 January 2018

1 reference

Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins

21 January 2018

1 reference

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

21 January 2018

1 reference

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

21 January 2018

1 reference

First-order rate-determining aggregation mechanism of p53 and its implications

21 January 2018

1 reference

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity.

21 January 2018

1 reference

p53 Aggregates penetrate cells and induce the co-aggregation of intracellular p53.

21 January 2018

1 reference

Novel proteinaceous infectious particles cause scrapie

21 January 2018

1 reference

Identification of a protein that purifies with the scrapie prion.

21 January 2018

1 reference

A protease-resistant protein is a structural component of the scrapie prion.

21 January 2018

1 reference

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

21 January 2018

1 reference

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

21 January 2018

1 reference

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

21 January 2018

1 reference

Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity

21 January 2018

1 reference

Cell-free formation of protease-resistant prion protein.

21 January 2018

1 reference

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier

21 January 2018

1 reference

Molecular characteristics of prion rods purified from scrapie-infected hamster brains

21 January 2018

1 reference

Scrapie-associated fibrils in Creutzfeldt–Jakob disease

21 January 2018

1 reference

Self-replication and scrapie

21 January 2018

1 reference

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation

21 January 2018

1 reference

Amplification of purified prions in vitro

21 January 2018

1 reference

Intriguing nucleic-acid-binding features of mammalian prion protein

21 January 2018

1 reference

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

21 January 2018

1 reference

A generic crystallization-like model that describes the kinetics of amyloid fibril formation.

21 January 2018

1 reference

How is actin polymerization nucleated in vivo?

21 January 2018

1 reference

21 January 2018

Microtubule nucleation.

1 reference

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

21 January 2018

1 reference

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

21 January 2018

1 reference

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

21 January 2018

1 reference

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

21 January 2018

1 reference

Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

1 reference

Hyperphosphorylation and cleavage at D421 enhance tau secretion

21 January 2018

1 reference

Trans-cellular propagation of Tau aggregation by fibrillar species

21 January 2018

1 reference

The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

1 reference

Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease.

21 January 2018

1 reference

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

21 January 2018

1 reference

Diversity, biogenesis and function of microbial amyloids

21 January 2018

1 reference

A neuronal isoform of the aplysia CPEB has prion-like properties

21 January 2018

1 reference

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

21 January 2018

1 reference

Structural biology of the tumor suppressor p53.

21 January 2018

1 reference

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

21 January 2018

1 reference

Mutant p53: one name, many proteins

21 January 2018

1 reference

21 January 2018

p53 mutations in cancer

1 reference

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

1 reference

How many mutant p53 molecules are needed to inactivate a tetramer?

21 January 2018

1 reference

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

21 January 2018

1 reference

Role of the newer p53 family proteins in malignancy

21 January 2018

1 reference

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

21 January 2018

1 reference

Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.

21 January 2018

1 reference

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant

21 January 2018

1 reference

The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies.

21 January 2018

1 reference

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 January 2018

1 reference

Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies

21 January 2018

1 reference

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

21 January 2018

1 reference

The Zyggregator method for predicting protein aggregation propensities

21 January 2018

1 reference

Potential roles for prions and protein-only inheritance in cancer

21 January 2018

1 reference

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

21 January 2018

1 reference

Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.

21 January 2018

1 reference

An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation

21 January 2018

1 reference

Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.

21 January 2018

1 reference

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

21 January 2018

1 reference

Analysis of p53-RNA interactions in cultured human cells

21 January 2018

1 reference

The tumor suppressor p53 is bound to RNA by a stable covalent linkage

21 January 2018

1 reference

Binding of RNA to p53 regulates its oligomerization and DNA-binding activity

21 January 2018

1 reference

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

21 January 2018

1 reference

Folding of a cyclin box: linking multitarget binding to marginal stability, oligomerization, and aggregation of the retinoblastoma tumor suppressor AB pocket domain

21 January 2018

1 reference

p53 as the main traffic controller of the cell signaling network

21 January 2018

1 reference

21 January 2018

Surfing the p53 network

1 reference

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

Cyclin a-CDK phosphorylation regulates MDM2 protein interactions

21 January 2018

1 reference

Functions of the MDM2 oncoprotein

21 January 2018

1 reference

Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer

21 January 2018

1 reference

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

RNAi: a potential new class of therapeutic for human genetic disease

21 January 2018

1 reference

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

21 January 2018

1 reference

Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy

21 January 2018

1 reference

Autophagy modulation as a potential therapeutic target for diverse diseases

21 January 2018

1 reference

Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells

21 January 2018

1 reference

Prion-like propagation of protein aggregation and related therapeutic strategies

21 January 2018

1 reference

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

21 January 2018

1 reference

Current strategies to target p53 in cancer.

21 January 2018

1 reference

Awakening guardian angels: drugging the p53 pathway

21 January 2018

1 reference

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

21 January 2018

1 reference

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

21 January 2018

1 reference

Small molecule induced reactivation of mutant p53 in cancer cells

21 January 2018

1 reference

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

Waltz, an exciting new move in amyloid prediction.

21 January 2018

1 reference

12 December 2020

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

12 December 2020

Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells

1 reference

12 December 2020

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

1 reference

12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

12 December 2020

The p53 and mdm-2 genes in human testicular germ-cell tumors

1 reference

12 December 2020

Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids

1 reference

12 December 2020

Identifiers

DOI

10.4161/PRI.27776

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24509441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24509441%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24509441%20AND%20SRC:MED&resulttype=core&format=json