The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases (Q38394355)

2 September 2017

1 reference

title

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases (English)

1 reference

Coenraad Dirk Adriaan Stehouwer

2 September 2017

series ordinal

2

object named as

Coen D A Stehouwer

1 reference

2 September 2017

3

Casper G Schalkwijk

1 reference

2 September 2017

Dionne E M Maessen

1

1 reference

PubMed ID

25818485

2 September 2017

language of work or name

English

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publication date

1 June 2015

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2 September 2017

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2 September 2017

128

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2 September 2017

839-861

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2 September 2017

12

1 reference

Advanced glycation end-products: a review

2 September 2017

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Biochemistry and molecular cell biology of diabetic complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal, obesity, and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal and glyoxalase I in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase in tumourigenesis and multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal, cognitive function and cerebral atrophy in older people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The glyoxalase pathway: the first hundred years... and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Modification of the glyoxalase system in human red blood cells by glucose in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Acetone metabolism in humans during diabetic ketoacidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glycoxidation and lipoxidation in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Where does plasma methylglyoxal originate from?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Prandial glucose regulation in the glucose triad: emerging evidence and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase in diabetes, obesity and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Dicarbonyl proteome and genome damage in metabolic and vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of arg-410 and tyr-411 in human serum albumin for ligand binding and esterase-like activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Albumin antioxidant capacity is modified by methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Synthesis and secretion of tumour necrosis factor-alpha by human monocytic THP-1 cells and chemotaxis induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal-bovine serum albumin stimulates tumor necrosis factor alpha secretion in RAW 264.7 cells through activation of mitogen-activating protein kinase, nuclear factor kappaB and intracellular reactive oxygen species formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal-induced modifications of hemoglobin: structural and functional characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Hyperglycemia impairs proteasome function by methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Heat shock protein 27 modification is increased in the human diabetic failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Determination of glycated nucleobases in human urine by a new monoclonal antibody specific for N2-carboxyethyl-2'-deoxyguanosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Advanced glycation end products of DNA: quantification of N2-(1-Carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal induces DNA crosslinks in ECV304 cells via a reactive oxygen species-independent protein carbonylation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Characterization of the deoxyguanosine-lysine cross-link of methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal mediated conformational changes in histone H2A-generation of carboxyethylated advanced glycation end products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Kinetic evaluation of substrate specificity in the glyoxalase-I-catalyzed disproportionation of α-ketoaldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I is a novel nitric-oxide-responsive protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The glyoxalase system in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Copy number variation of glyoxalase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic association and functional correlates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Human DJ-1 and its homologs are novel glyoxalases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Vascular complications in diabetes mellitus: the role of endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of endothelial cell metabolism in vessel sprouting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Endothelial dysfunction in diabetes: potential application of circulating markers as advanced diagnostic and prognostic tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal promotes oxidative stress and endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal induces hprt mutation and DNA adducts in human T-lymphocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Mechanisms of diabetic complications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Early progression of diabetic nephropathy correlates with methylglyoxal-derived advanced glycation end products

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Knockdown of glyoxalase 1 mimics diabetic nephropathy in nondiabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased serum levels of the specific advanced glycation end product methylglyoxal-derived hydroimidazolone are associated with retinopathy in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

High concentrations of glucose induce synthesis of argpyrimidine in retinal endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal induces cellular damage by increasing argpyrimidine accumulation and oxidative DNA damage in human lens epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of advanced glycation end products in diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Skin advanced glycation end products glucosepane and methylglyoxal hydroimidazolone are independently associated with long-term microvascular complication progression of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal evokes pain by stimulating TRPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of methylglyoxal on the physico-chemical and biological properties of low-density lipoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The metabolism and anti-atherogenic properties of HDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Arginine-directed glycation and decreased HDL plasma concentration and functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glycation of human high density lipoprotein by methylglyoxal: effect on HDL-paraoxonase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal further impairs adipose tissue metabolism after partial decrease of blood supply.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Differential expression of skeletal muscle proteins in high-fat diet-fed rats in response to capsaicin feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Modulation of insulin action by advanced glycation endproducts: a new player in the field

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Structural and functional changes in human insulin induced by methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Uptake of [18F]fluorodeoxyglucose in human monocyte-macrophages in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Vascular methylglyoxal metabolism and the development of hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Two α-dicarbonyls downregulate migration, invasion, and adhesion of liver cancer cells in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Rapid suppression of mitochondrial permeability transition by methylglyoxal. Role of reversible arginine modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Role for glyoxalase I in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal reduces mitochondrial potential and activates Bax and caspase-3 in neurons: Implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Enhanced carbonyl stress in a subpopulation of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Protein biomarkers in a mouse model of extremes in trait anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Age-dependent changes of glyoxalase I expression in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

C. elegans as model for the study of high glucose- mediated life span reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I retards renal senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Methylglyoxal concentration and glyoxalase activities in the human lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I activity and immunoreactivity in the aging human lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Epigenetics in cancer: implications for early detection and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Therapeutic potential of breakers of advanced glycation end product–protein crosslinks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Molecular basis of arterial stiffening: role of glycation - a mini-review

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Current therapeutic interventions in the glycation pathway: evidence from clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Improved arterial compliance by a novel advanced glycation end-product crosslink breaker

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Cellular and molecular mechanisms of metformin: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Reducing insulin resistance with metformin: the evidence today

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Renoprotective effects of the AGE-inhibitor pyridoxamine in experimental chronic allograft nephropathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Pyridorin in type 2 diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

A preliminary evaluation of bardoxolone methyl for the treatment of diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

Bardoxolone: augmenting the Yin in chronic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FCS20140683

21 January 2018

Identifiers

DOI

10.1042/CS20140683

1 reference

2 September 2017

1 reference

PubMed ID

25818485