Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway (Q38655417)

5 September 2017

title

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway (English)

1 reference

5 September 2017

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

4

Pierre Sonveaux

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1

Valéry L Payen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Bjorn Baselet

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

1 December 2015

1 reference

Cellular and Molecular Life Sciences

5 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

73

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

1333-1348

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26626411%20AND%20SRC:MED&resulttype=core&format=json

Cancer metastasis: building a framework

8 June 2020

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The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs

21 January 2018

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21 January 2018

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Origins of metastatic traits

21 January 2018

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Are cancer cells acidic?

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The contributions of respiration and glycolysis to extracellular acid production

21 January 2018

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Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

21 January 2018

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Proton channels and exchangers in cancer

21 January 2018

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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Biochemistry of exercise-induced metabolic acidosis

21 January 2018

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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

21 January 2018

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Clastogenicity of low pH to various cultured mammalian cells

21 January 2018

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Acidic environment causes apoptosis by increasing caspase activity

21 January 2018

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An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Biased activation of human T lymphocytes due to low extracellular pH is antagonized by B7/CD28 costimulation.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Drug resistance and cellular adaptation to tumor acidic pH microenvironment

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

An acidic extracellular pH induces Src kinase-dependent loss of beta-catenin from the adherens junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Carbonic anhydrase IX: regulation and role in cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Acidic priming enhances metastatic potential of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion

21 January 2018

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Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

21 January 2018

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Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Extracellular acidification alters lysosomal trafficking in human breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Na+/H+ exchangers and RhoA regulate acidic extracellular pH-induced lysosome trafficking in prostate cancer cells

21 January 2018

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HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers

21 January 2018

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Slow induction of gelatinase B mRNA by acidic culture conditions in mouse metastatic melanoma cells

21 January 2018

1 reference

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Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Acidic pH enhances the invasive behavior of human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Heparan sulfate degradation: relation to tumor invasive and metastatic properties of mouse B16 melanoma sublines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Acid treatment of melanoma cells selects for invasive phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

A mitochondrial switch promotes tumor metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Regulation of interleukin-8 expression by cellular pH in human pancreatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

VEGF receptor signalling - in control of vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Bicarbonate increases tumor pH and inhibits spontaneous metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Reduction of metastasis using a non-volatile buffer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Mechanisms of buffer therapy resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Tumor cell autocrine motility factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Autocrine motility factor signaling enhances pancreatic cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Phosphoglucose isomerase enhances colorectal cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Autocrine motility factor modulates EGF-mediated invasion signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Tumor autocrine motility factor is an angiogenic factor hat stimulates endothelial cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Tumor autocrine motility factor induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Novel invadopodia components revealed by differential proteomic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Glycolysis as primary energy source in tumor cell chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Influence of cell detachment on the respiration rate of tumor and endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Common responses of tumors and wounds to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

The monocarboxylate transporter family--Structure and functional characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Manipulation of glycolysis in malignant tumors: fantasy or therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Hypoxia and hypoxia-inducible factors: master regulators of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

The genomic analysis of lactic acidosis and acidosis response in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Adaptation of energy metabolism in breast cancer brain metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Identification and validation of dysregulated metabolic pathways in metastatic renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2098-5

Malic enzyme 1 induces epithelial-mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma

21 January 2018

1 reference

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Quantitative flux analysis reveals folate-dependent NADPH production.

21 January 2018

1 reference

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6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met

21 January 2018

1 reference

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Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer

21 January 2018

1 reference

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Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

21 January 2018

1 reference

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The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells

21 January 2018

1 reference

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Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells

21 January 2018

1 reference

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Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer

21 January 2018

1 reference

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Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases.

21 January 2018

1 reference

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Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation

21 January 2018

1 reference

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Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1.

21 January 2018

1 reference

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Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells

21 January 2018

1 reference

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Monocarboxylate transporter MCT1 is a target for immunosuppression

21 January 2018

1 reference

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Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

21 January 2018

1 reference

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Metabolic acidosis and the importance of balanced equations

21 January 2018

1 reference

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Targeting carbonic anhydrase IX with small organic ligands

21 January 2018

1 reference

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pH-sensitive nano-systems for drug delivery in cancer therapy

21 January 2018

1 reference

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pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances

21 January 2018

1 reference

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Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

21 January 2018

1 reference

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

1 reference

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

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Cell surface lactate receptor GPR81 is crucial for cancer cell survival

21 January 2018

1 reference

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Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

21 January 2018

1 reference

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How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

21 January 2018

1 reference

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An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.

21 January 2018

1 reference

12 December 2020

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

1 reference

12 December 2020

Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux

1 reference

12 December 2020

Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli

1 reference

12 December 2020

Expression of autocrine motility factor receptor in human esophageal squamous cell carcinoma

1 reference

12 December 2020

Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells

1 reference

12 December 2020

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1 reference

12 December 2020

Prognostic significance of monocarboxylate transporter 4 expression in patients with colorectal cancer

1 reference

12 December 2020

Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines

1 reference

12 December 2020

Serum phosphohexose isomerase activities in patients with colorectal cancer.

1 reference

12 December 2020

Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1.

1 reference

12 December 2020

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1 reference

12 December 2020

Role of interleukin-8 in tumor growth and metastasis of human melanoma

1 reference

12 December 2020

Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells

1 reference

12 December 2020

Ha-ras oncogene induction of invasion and metastasis is associated with the activation and redistribution of protease(s) in rat-kidney cells

1 reference

12 December 2020

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release

1 reference

12 December 2020

NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1-MMP

1 reference

12 December 2020

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells

1 reference

12 December 2020

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells

1 reference

12 December 2020

Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases

1 reference

12 December 2020

Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

1 reference

12 December 2020

Overexpression of the autocrine motility factor/phosphoglucose isomerase induces transformation and survival of NIH-3T3 fibroblasts

1 reference

12 December 2020

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism

1 reference

12 December 2020

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer

1 reference

12 December 2020

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor

1 reference

12 December 2020

Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved

1 reference

12 December 2020

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

12 December 2020

Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.

1 reference

12 December 2020

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice

1 reference

12 December 2020

Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress

1 reference

12 December 2020

Mutagenesis induced by the tumor microenvironment

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Correlation of high lactate levels in human cervical cancer with incidence of metastasis

1 reference

12 December 2020

Autocrine motility factor in pulmonary adenocarcinomas: results of an immunohistochemical study

1 reference

12 December 2020

Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells

1 reference

12 December 2020

Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.

1 reference

12 December 2020

Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

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12 December 2020

Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.

1 reference

12 December 2020

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

1 reference

12 December 2020

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

12 December 2020

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

1 reference

12 December 2020

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

1 reference

12 December 2020

Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion

1 reference

12 December 2020

CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells

1 reference

12 December 2020

Activation of small GTPase Rho is required for autocrine motility factor signaling.

1 reference

12 December 2020

Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer

1 reference

12 December 2020

Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH

1 reference

12 December 2020

Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model.

1 reference

12 December 2020

The effects of extracellular pH on immune function

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

12 December 2020

Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

1 reference

12 December 2020