Maintaining cell identity: PRC2-mediated regulation of transcription and cancer (Q38961785)

8 September 2017

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title

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer (English)

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8 September 2017

4

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8 September 2017

Itys Comet

1

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Benjamin Leblanc

object named as

Benjamin Leblanc

series ordinal

3

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Eva M Riising

object named as

Eva M Riising

series ordinal

2

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language of work or name

English

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publication date

23 September 2016

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8 September 2017

published in

Nature Reviews Cancer

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8 September 2017

volume

16

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8 September 2017

issue

12

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8 September 2017

page(s)

803-810

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Chromatin proteins and modifications as drug targets

8 September 2017

cites work

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

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EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms

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PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

21 January 2018

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1

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Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

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Context-dependent actions of Polycomb repressors in cancer

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The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?

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A gene complex controlling segmentation in Drosophila

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Suz12 binds to silenced regions of the genome in a cell-type-specific manner

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

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Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

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Chromosomal distribution of PcG proteins during Drosophila development

21 January 2018

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Genome-wide analysis of Polycomb targets in Drosophila melanogaster

21 January 2018

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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

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Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.

21 January 2018

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Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation

21 January 2018

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Ras-induced changes in H3K27me3 occur after those in transcriptional activity

21 January 2018

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Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation

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GC-rich sequence elements recruit PRC2 in mammalian ES cells

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EZH2 mutations are frequent and represent an early event in follicular lymphoma

21 January 2018

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EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

21 January 2018

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Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma

21 January 2018

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Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2 expands breast stem cells through activation of NOTCH1 signaling

21 January 2018

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Regulation of tumor angiogenesis by EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Epigenetic stem cell signature in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Revolution in the Polycomb hierarchy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

A687V EZH2 is a gain-of-function mutation found in lymphoma patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.83

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products

31 March 2020

1 reference

12 December 2020

Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila

1 reference

12 December 2020

The molecular basis for metameric pattern in the Drosophila embryo

1 reference

12 December 2020

Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster

1 reference

12 December 2020

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

1 reference

12 December 2020

Recruitment of components of Polycomb Group chromatin complexes in Drosophila.

1 reference

12 December 2020

The molecular basis for metameric pattern in the Drosophila embryo

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1242/DEV.101.1.1

Identifiers

DOI

10.1038/NRC.2016.83

1 reference

Dimensions Publication ID

8 September 2017

1027309366

0 references

1 reference