F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. (Q39108673)

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scientific article published on 16 August 2013

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English	F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.	scientific article published on 16 August 2013

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scholarly article

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7 March 2020

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation (English)

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7 March 2020

endoplasmic reticulum

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Masaki Matsumoto

2

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Kanae Yumimoto

1

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Ichiro Onoyama

3

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Kazunori Imaizumi

4

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Keiichi I Nakayama

5

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16 August 2013

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Journal of Biological Chemistry

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288

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28488-28502

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7 March 2020

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

1 reference

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Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

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GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α

1 reference

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Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia

1 reference

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Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

1 reference

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FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

1 reference

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Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

1 reference

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The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation

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The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs

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Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

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Notch and the skeleton

1 reference

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Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

1 reference

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Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

1 reference

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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

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Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

1 reference

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9 September 2017

SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

1 reference

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9 September 2017

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Notch signalling: a simple pathway becomes complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Ubiquitin ligases: cell-cycle control and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

1 reference

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Systematic analysis and nomenclature of mammalian F-box proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

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1 reference

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9 September 2017

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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9 September 2017

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

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9 September 2017

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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9 September 2017

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 reference

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9 September 2017

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes and gliotic tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

9 September 2017

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1 reference

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9 September 2017

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1 reference

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9 September 2017

The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

14 September 2017

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14 September 2017

Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.

1 reference

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15 June 2018

Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells

1 reference

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15 June 2018

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

21 August 2018

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

1 reference

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21 August 2018

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

1 reference

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21 August 2018

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

1 reference

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21 August 2018

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

21 August 2018

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

21 August 2018

Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789950

21 August 2018

Comprehensive identification of substrates for F-box proteins by differential proteomics analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-Inducible Factor-1 (HIF-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23955342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.465179

1 reference

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7 March 2020

1 reference

Europe PubMed Central

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7 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23955342%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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