Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights (Q39135148)

9 September 2017

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights (English)

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9 September 2017

3

Matthew Bogyo

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9 September 2017

David S Hewings

1

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9 September 2017

John A Flygare

series ordinal

2

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9 September 2017

Ingrid E Wertz

series ordinal

4

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9 September 2017

language of work or name

English

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publication date

14 February 2017

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9 September 2017

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9 September 2017

284

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9 September 2017

10

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9 September 2017

1555-1576

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https://api.crossref.org/works/10.1111%2FFEBS.14039

9 September 2017

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The discovery of ubiquitin-dependent proteolysis

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

The emerging complexity of protein ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

A proteomics approach to understanding protein ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin signaling in immune responses

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Linear ubiquitination in immunity

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin and ubiquitin-like proteins in protein regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Prokaryotic ubiquitin-like protein modification

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

New insights into ubiquitin E3 ligase mechanism

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

DUBs, the regulation of cell identity and disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Breaking the chains: structure and function of the deubiquitinases

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Pharmacological activation of wild-type p53 in the therapy of leukemia

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Promises and Challenges of Smac Mimetics as Cancer Therapeutics

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based profiling of proteases

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Chemistry in living systems

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Chemical and semisynthetic approaches to study and target deubiquitinases.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

How Chemical Synthesis of Ubiquitin Conjugates Helps To Understand Ubiquitin Signal Transduction

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Synthetic and semi-synthetic strategies to study ubiquitin signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Chemical strategies to understand the language of ubiquitin signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Structural basis for the specificity of ubiquitin C-terminal hydrolases

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Development of small molecule inhibitors and probes of human SUMO deconjugating proteases

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinases as a signaling target of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinating function of adenovirus proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Identification and characterization of DEN1, a deneddylase of the ULP family

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Substrate specificity of the ubiquitin and Ubl proteases

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Dehydroalanine-based diubiquitin activity probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A native chemical ligation handle that enables the synthesis of advanced activity-based probes: diubiquitin as a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Otubains: a new family of cysteine proteases in the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

ElaD, a Deubiquitinating protease expressed by E. coli

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Characterisation of the Trichinella spiralis deubiquitinating enzyme, TsUCH37, an evolutionarily conserved proteasome interaction partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinase inhibition as a cancer therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Inhibiting the deubiquitinating enzymes (DUBs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Deubiquitinases (DUBs) and DUB inhibitors: a patent review

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.14039

Active site remodelling accompanies thioester bond formation in the SUMO E1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

An inhibitor of ubiquitin conjugation and aggresome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Proteomics evaluation of chemically cleavable activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A simple and effective cleavable linker for chemical proteomics applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

A Strategy for Modulation of Enzymes in the Ubiquitin System

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Expanding the ubiquitin code through post-translational modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Selenocysteine as a latent bioorthogonal electrophilic probe for deubiquitylating enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Fluorescence-based active site probes for profiling deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Small-Molecule Inhibitors and Probes for Ubiquitin- and Ubiquitin-Like-Specific Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.14039

Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors

21 January 2018

1 reference

12 December 2020

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

1 reference

12 December 2020

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

1 reference

12 December 2020

Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin

1 reference

12 December 2020

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

1 reference

12 December 2020

Glycine Fluoromethylketones as SENP-Specific Activity Based Probes

1 reference

12 December 2020

Identifiers

DOI

10.1111/FEBS.14039

1 reference

9 September 2017

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