Direct induction of apoptosis using an optimal mitochondrially targeted p53. (Q39387682)

11 September 2017

Direct induction of apoptosis using an optimal mitochondrially targeted p53. (English)

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11 September 2017

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Mohanad Mossalam

1

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11 September 2017

Karina J Matissek

2

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11 September 2017

Abood Okal

3

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11 September 2017

Jonathan E Constance

4

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11 September 2017

Carol S Lim

5

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11 September 2017

language of work or name

English

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publication date

28 March 2012

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11 September 2017

Molecular Pharmaceutics

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9

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5

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1449-1458

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describes a project that uses

11 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3377387/fullTextXML

inferred from PubMed Central ID database lookup

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Perforin rapidly induces plasma membrane phospholipid flip-flop

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Controlling subcellular delivery to optimize therapeutic effect

11 September 2017

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Bcl-2 proteins and mitochondria--specificity in membrane targeting for death

11 September 2017

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The mitochondrial transcription factor A functions in mitochondrial base excision repair

11 September 2017

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Mitochondrial protein import: from proteomics to functional mechanisms

11 September 2017

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BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain

11 September 2017

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The mitochondrial p53 pathway

11 September 2017

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Targeting p53 to mitochondria for cancer therapy

11 September 2017

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11 September 2017

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Monoubiquitylation promotes mitochondrial p53 translocation

11 September 2017

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A guided tour into subcellular colocalization analysis in light microscopy

11 September 2017

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The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis

11 September 2017

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Controlling protein compartmentalization to overcome disease

11 September 2017

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Evolution of the molecular machines for protein import into mitochondria

11 September 2017

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Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine

11 September 2017

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Stress-induced p53 runs a transcription-independent death program

11 September 2017

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The p53 pathway: positive and negative feedback loops

11 September 2017

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New developments in mitochondrial assembly

11 September 2017

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

11 September 2017

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Mitochondrial import and the twin-pore translocase

11 September 2017

1 reference

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Automatic and quantitative measurement of protein-protein colocalization in live cells.

11 September 2017

1 reference

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

11 September 2017

1 reference

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The protein import machinery of mitochondria

11 September 2017

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

11 September 2017

1 reference

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p53 has a direct apoptogenic role at the mitochondria

11 September 2017

1 reference

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Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

11 September 2017

1 reference

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Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells

11 September 2017

1 reference

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Functions of outer membrane receptors in mitochondrial protein import

11 September 2017

1 reference

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Apoptosis and aging: role of the mitochondria

11 September 2017

1 reference

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Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

11 September 2017

1 reference

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11 September 2017

Surfing the p53 network

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Transport between the cell nucleus and the cytoplasm

11 September 2017

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Nucleocytoplasmic transport: the soluble phase

11 September 2017

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Mitochondria and apoptosis

11 September 2017

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

11 September 2017

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Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

11 September 2017

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A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

11 September 2017

1 reference

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Mitochondrial import and processing of mutant human ornithine transcarbamylase precursors in cultured cells

11 September 2017

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Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry

11 September 2017

1 reference

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Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase

11 September 2017

1 reference

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The tetramerization domain of p53 is required for efficient BAK oligomerization

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Controlling subcellular localization to alter function: Sending oncogenic Bcr-Abl to the nucleus causes apoptosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Cytochrome c: can't live with it--can't live without it.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Mitochondrial targeting sequences may form amphiphilic helices

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

An automated method to quantify and visualize colocalized fluorescent signals.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Overexpression of wild-type p53 gene renders MCF-7 breast cancer cells more sensitive to the antiproliferative effect of progesterone.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Detection of mitochondrial localization of p53.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Evaluation of a gemcitabine-doxorubicin-paclitaxel combination schedule through flow cytometry assessment of apoptosis extent induced in human breast cancer cell lines

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

Rapid development of tamoxifen-stimulated mutant p53 breast tumors (T47D) in athymic mice.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3377387

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

21 August 2018

1 reference

12 December 2020

Quantifying colocalization by correlation: the Pearson correlation coefficient is superior to the Mander's overlap coefficient

1 reference

12 December 2020

Protein synthesis-dependent cytoplasmic translocation of p53 protein after serum stimulation of growth-arrested MCF-7 cells

1 reference

12 December 2020

The nuclear-coded subunits of yeast cytochrome c oxidase. II. The amino acid sequence of subunit VIII and a model for its disposition in the inner mitochondrial membrane

1 reference

12 December 2020

A matter of life and death

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12 December 2020

Measurement of cell death

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12 December 2020

Mitochondrial presequences

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12 December 2020

Identifiers

DOI

10.1021/MP3000259

1 reference

11 September 2017

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11 September 2017

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