Ubiquitin-proteasome pathway mediates degradation of APH-1. (Q40216642)

18 September 2017

title

Ubiquitin-proteasome pathway mediates degradation of APH-1. (English)

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ubiquitin-proteasome system

18 September 2017

main subject

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Weihong Song

8

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author name string

Guiqiong He

1

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18 September 2017

Hong Qing

2

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18 September 2017

Fang Cai

3

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18 September 2017

Clement Kwok

4

1 reference

18 September 2017

Huaxi Xu

5

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18 September 2017

Gang Yu

6

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18 September 2017

Alan Bernstein

7

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18 September 2017

language of work or name

English

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publication date

24 October 2006

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Journal of Neurochemistry

18 September 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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18 September 2017

volume

99

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18 September 2017

issue

5

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18 September 2017

page(s)

1403-1412

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Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Proteasomal degradation of tau protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Presenilin 1 is actively degraded by the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Themes and variations on ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04184.X

10.1111/J.1471-4159.2006.04184.X

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference