PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain (Q42043417)

15 October 2017

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain (English)

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15 October 2017

8

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15 October 2017

Mali Liu

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15 October 2017

Guoxin Wu

2

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15 October 2017

Jennifer Baysarowich

3

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15 October 2017

Michael Kavana

4

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15 October 2017

George H Addona

5

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15 October 2017

Kathleen K Bierilo

6

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15 October 2017

John S Mudgett

7

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15 October 2017

Ayesha Sitlani

9

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15 October 2017

John J Renger

10

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15 October 2017

Brian K Hubbard

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15 October 2017

Timothy S Fisher

12

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15 October 2017

Celina V Zerbinatti

13

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15 October 2017

7 May 2010

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Journal of Lipid Research

15 October 2017

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15 October 2017

51

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15 October 2017

2611-2618

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15 October 2017

9

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describes a project that uses

15 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2918444/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

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Reelin signaling antagonizes beta-amyloid at the synapse

5 June 2018

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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

5 June 2018

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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

5 June 2018

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Apolipoprotein E receptors in the nervous system

5 June 2018

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

5 June 2018

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Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

5 June 2018

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Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease.

5 June 2018

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Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

5 June 2018

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

5 June 2018

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PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

5 June 2018

1 reference

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PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.

5 June 2018

1 reference

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Plasma PCSK9 preferentially reduces liver LDL receptors in mice

5 June 2018

1 reference

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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

5 June 2018

1 reference

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Molecular basis for LDL receptor recognition by PCSK9

5 June 2018

1 reference

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The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

5 June 2018

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

5 June 2018

1 reference

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Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

5 June 2018

1 reference

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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

5 June 2018

1 reference

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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

5 June 2018

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

5 June 2018

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Molecular biology of PCSK9: its role in LDL metabolism

5 June 2018

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

5 June 2018

1 reference

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Reelin, lipoprotein receptors and synaptic plasticity

5 June 2018

1 reference

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

5 June 2018

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

5 June 2018

1 reference

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

5 June 2018

1 reference

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

5 June 2018

1 reference

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

5 June 2018

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

5 June 2018

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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

5 June 2018

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

5 June 2018

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

5 June 2018

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

5 June 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

5 June 2018

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Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

5 June 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

5 June 2018

1 reference

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Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918444

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918444

Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918444

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918444

Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2918444

17 August 2018

Identifiers

DOI

10.1194/JLR.M006635

1 reference

15 October 2017

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15 October 2017

1 reference