Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. (Q46178162)

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19 January 2020

title

Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons (English)

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19 January 2020

4

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19 January 2020

author name string

Matthew A King

1

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19 January 2020

Christoph G Goemans

2

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19 January 2020

Farida Hafiz

3

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19 January 2020

Andreas Wyttenbach

5

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19 January 2020

Aviva M Tolkovsky

6

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19 January 2020

language of work or name

English

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publication date

1 December 2008

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19 January 2020

published in

Journal of Neuroscience

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19 January 2020

volume

28

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19 January 2020

issue

53

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19 January 2020

page(s)

14401-14415

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

19 January 2020

cites work

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons

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BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

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Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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Negative regulation of the Apaf-1 apoptosome by Hsp70

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12 December 2020

Phosphatidylinositol 3-kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons

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c-Jun and the transcriptional control of neuronal apoptosis

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Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

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Stress management - heat shock protein-70 and the regulation of apoptosis

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Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

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Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

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Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons: a potential role for mitochondrial permeability transition

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Nerve Growth Factor is Required for Induction of c-Fos Immunoreactivity by Serum, Depolarization, Cyclic AMP or Trauma in Cultured Rat Sympathetic Neurons

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Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

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Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

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12 December 2020

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

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12 December 2020

Bax, Reactive Oxygen, and CytochromecRelease in Neuronal Apoptosis

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Men are but worms: neuronal cell death in C elegans and vertebrates

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Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

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Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

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12 December 2020

Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways

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12 December 2020

Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.

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12 December 2020

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway

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12 December 2020

Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons

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12 December 2020

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

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Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

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Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death

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Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

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Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

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12 December 2020

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway.

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12 December 2020

Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors

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12 December 2020

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

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12 December 2020

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation

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12 December 2020

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

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12 December 2020

Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates

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12 December 2020

Protein synthesis upon acute nutrient restriction relies on proteasome function

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12 December 2020

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

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12 December 2020

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

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12 December 2020

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

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12 December 2020

Stochastic kinetics of intracellular huntingtin aggregate formation.

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12 December 2020

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

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Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

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Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

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Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons.

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12 December 2020

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

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12 December 2020

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

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BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

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12 December 2020

Trinucleotide Repeat Disorders

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12 December 2020

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

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12 December 2020

Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun.

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12 December 2020

Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors

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12 December 2020

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

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12 December 2020

A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons

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12 December 2020

Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.

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Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

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Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease

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53 Long-term culture of dissociated sympathetic neurons

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12 December 2020

Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome

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Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

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12 December 2020

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

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BAX is required for neuronal death after trophic factor deprivation and during development

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Antisense oligodeoxynucleotides to bax mRNA promote survival of rat sympathetic neurons in culture

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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12 December 2020

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Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

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12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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12 December 2020

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

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Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length

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10.1523/JNEUROSCI.4751-08.2008

Identifiers

DOI

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19 January 2020

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19 January 2020

PubMed publication ID

19118173

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