Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. (Q50052760)

http://europepmc.org/abstract/PMC/5802278

24 February 2018

title

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. (English)

1 reference

http://europepmc.org/abstract/PMC/5802278

24 February 2018

author

Akane Kawamura

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Peter J. Ratcliffe

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Rasheduzzaman Chowdhury

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Christopher J. Schofield

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

T-L Yeh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Martine I. Abboud

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Cyrille C Thinnes

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Onur Atasoylu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Christopher T Lohans

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Ivanhoe K. H. Leung

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Ian J Clifton

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Emily Flashman

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Xin Lu

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Chris Pugh

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

14

Timothy D W Claridge

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

8

Anthony Tumber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

6

James P Holt-Martyn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

9

Kerstin Lippl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Thomas M Leissing

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Dong Zhang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Helen Morcrette

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

11 September 2017

1 reference

http://europepmc.org/abstract/PMC/5802278

24 February 2018

published in

Chemical Science

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

7651-7668

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

2 June 2020

cites work

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22 May 2018

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22 May 2018

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Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model

22 May 2018

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Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)

22 May 2018

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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

22 May 2018

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Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis

22 May 2018

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Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

22 May 2018

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22 May 2018

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22 May 2018

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Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model

22 May 2018

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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

22 May 2018

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22 May 2018

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Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

22 May 2018

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Structural and functional insights into Saccharomyces cerevisiae Tpa1, a putative prolylhydroxylase influencing translation termination and transcription

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors

22 May 2018

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Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

22 May 2018

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22 May 2018

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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

22 May 2018

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22 May 2018

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Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

22 May 2018

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Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

22 May 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

22 May 2018

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

22 May 2018

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Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues.

22 May 2018

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Signalling hypoxia by HIF hydroxylases

22 May 2018

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

22 May 2018

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Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene

22 May 2018

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22 May 2018

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Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

22 May 2018

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Refinement of macromolecular structures by the maximum-likelihood method

22 May 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

22 May 2018

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Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

22 May 2018

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Oxygen sensing by HIF hydroxylases

22 May 2018

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Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

22 May 2018

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Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

22 May 2018

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

22 May 2018

1 reference

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

22 May 2018

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

22 May 2018

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

A conserved family of prolyl-4-hydroxylases that modify HIF

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

HIF-1 and mechanisms of hypoxia sensing

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Prolyl 3-Hydroxylase: Partial Characterization of the Enzyme from Rat Kidney Cortex

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Mass spectrometric characterization of a prolyl hydroxylase inhibitor GSK1278863, its bishydroxylated metabolite, and its implementation into routine doping controls.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Different modes of inhibitor binding to prolyl hydroxylase by combined use of X-ray crystallography and NMR spectroscopy of paramagnetic complexes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

The CLIP/CLAP-HSQC: pure absorptive spectra for the measurement of one-bond couplings

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5802278

Studies on the lysyl hydroxylase reaction. I. Initial velocity kinetics and related aspects

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29435217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29435217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Spin echo NMR spectra without J modulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29435217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1039/C7SC02103H

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435217%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

29435217

1 reference