The presenilin mystery. The research winner-by-a knockout? (Q52576091)

3 May 2018

review article

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title

The presenilin mystery. The research winner-by-a knockout? (English)

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3 May 2018

author

Frédéric Checler

series ordinal

1

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3 May 2018

publication date

1 December 1999

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3 May 2018

Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie

published in

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3 May 2018

volume

322

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3 May 2018

issue

12

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3 May 2018

page(s)

1033-1038

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3 May 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Presenilins and Alzheimer disease

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7 January 2021

The presenilins and Alzheimer's disease

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7 January 2021

Presenilins: genes for life and death

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7 January 2021

Presenilins: structural aspects and posttranslational events.

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7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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7 January 2021

Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells.

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7 January 2021

Cell surface expression of the Alzheimer disease-related presenilin proteins

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7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

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7 January 2021

Presenilin-1 is processed into two major cleavage products in neuronal cell lines

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

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7 January 2021

Distinct processing of endogenous and overexpressed recombinant presenilin 1.

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7 January 2021

Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

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7 January 2021

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

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7 January 2021

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

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7 January 2021

Presenilins Are Processed by Caspase-type Proteases

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7 January 2021

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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7 January 2021

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

1 reference

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7 January 2021

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

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7 January 2021

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

1 reference

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7 January 2021

Presenilin 1 binds to amyloid precursor protein directly

1 reference

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7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

1 reference

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7 January 2021

Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system

1 reference

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7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

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7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

1 reference

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7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

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7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

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7 January 2021

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

1 reference

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7 January 2021

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

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7 January 2021

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

1 reference

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7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

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7 January 2021

Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0764-4469%2899%2900102-X

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0764-4469%2899%2900102-X

7 January 2021

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0764-4469%2899%2900102-X

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0764-4469%2899%2900102-X

7 January 2021

10.1016/S0764-4469(99)00102-X

Identifiers

DOI

1 reference

3 May 2018

1 reference

3 May 2018