A small-molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain. (Q52656406)

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27 February 2020

title

A small-molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain (English)

1 reference

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protein-protein interaction

27 February 2020

main subject

1 reference

5

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27 February 2020

Han-Ming Shen

6

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27 February 2020

Sijun Pan

4

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27 February 2020

author name string

Zhenkun Na

1

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27 February 2020

Bo Peng

2

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27 February 2020

Shukie Ng

3

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27 February 2020

Shao Q Yao

7

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language of work or name

English

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publication date

7 January 2015

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Angewandte Chemie International Edition

27 February 2020

number of pages

5

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based on heuristic

inferred from page(s)

published in

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volume

54

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issue

8

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page(s)

2515-2519

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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

27 February 2020

cites work

1 reference

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Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

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Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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New PARP targets for cancer therapy

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Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

21 January 2018

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BRCT domains: easy as one, two, three

21 January 2018

1 reference

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Structural studies of the PARP-1 BRCT domain

21 January 2018

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Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair

21 January 2018

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Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks.

21 January 2018

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Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).

21 January 2018

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Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

21 January 2018

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Microarray-assisted high-throughput identification of a cell-permeable small-molecule binder of 14-3-3 proteins.

21 January 2018

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Discovery of cell-permeable inhibitors that target the BRCT domain of BRCA1 protein by using a small-molecule microarray.

21 January 2018

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Inhibition of α-helix-mediated protein-protein interactions using designed molecules

21 January 2018

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

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Investigations on gossypol: past and present developments

21 January 2018

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Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.

21 January 2018

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Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

21 January 2018

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Combinatorial peptide microarrays for the rapid determination of kinase specificity

21 January 2018

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Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains.

21 January 2018

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4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

21 January 2018

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BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201410678

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25565365%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference