Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907. (Q54631286)

1 June 2018

title

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907. (English)

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8

Hans-Ulrich Häring

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10

Cora Weigert

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Erwin Schleicher

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object named as

Erwin D Schleicher

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author name string

Louise Fritsche

1

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Sabine S Neukamm

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Rainer Lehmann

3

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Elisabeth Kremmer

4

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Anita M Hennige

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Andrea Hunder-Gugel

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Martin Schenk

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publication date

23 November 2010

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American Journal of Physiology - Endocrinology and Metabolism

published in

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volume

300

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issue

5

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page(s)

E824-36

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

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21 January 2018

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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21 January 2018

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Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

21 January 2018

1 reference

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The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

21 January 2018

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Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

21 January 2018

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Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

21 January 2018

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

21 January 2018

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Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

21 January 2018

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10.1152/AJPENDO.00409.2010

21 January 2018

Identifiers

DOI

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1 June 2018

PubMed ID

21098738

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1 June 2018