catenin beta 1 (Q1634046)

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mammalian protein found in Homo sapiens
  • catenin beta-1
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • Beta-catenin
  • CTNNB1
  • CTNNB1 protein, human
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Language Label Description Also known as
English
catenin beta 1
mammalian protein found in Homo sapiens
  • catenin beta-1
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • Beta-catenin
  • CTNNB1
  • CTNNB1 protein, human

Statements

molecular function
protein binding
determination method
IPI
155 references
retrieved
1 January 2018
stated in
Loss of δ-catenin function in severe autism
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Regulation and function of the interaction between the APC tumour suppressor protein and EB1
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
beta-Catenin is a Nek2 substrate involved in centrosome separation
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Forkhead box F2 suppresses gastric cancer through a novel FOXF2-IRF2BPL-β-catenin signaling axis.
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic and genomic analysis of PITX2 interacting and regulating networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis of coactivation of liver receptor homolog-1 by  -catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Role of TAZ as mediator of Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
IpaC of Shigella binds to the C-terminal domain of beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Molecular basis of actin reorganization promoted by binding of enterohaemorrhagic Escherichia coli EspB to alpha-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The neurotransmitter dopamine modulates vascular permeability in the endothelium
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
In silico prediction of physical protein interactions and characterization of interactome orphans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Kaiso is a bimodal modulator for Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Identification of paxillin domains interacting with β-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The beta-catenin binding protein ICAT modulates androgen receptor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Structure of a human Tcf4-beta-catenin complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Telomerase modulates Wnt signalling by association with target gene chromatin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
E-cadherin regulates the association between beta-catenin and actinin-4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Yap1 acts downstream of α-catenin to control epidermal proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
IQGAP1 interacts with components of the slit diaphragm complex in podocytes and is involved in podocyte migration and permeability in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Targeting androgen receptor in estrogen receptor-negative breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Bcr interferes with beta-catenin-Tcf1 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The RNA aptamer disrupts protein-protein interaction between beta-catenin and nuclear factor-kappaB p50 and regulates the expression of C-reactive protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The Krüppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Receptor tyrosine phosphatase PTPγ is a regulator of spinal cord neurogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The kinase TNIK is an essential activator of Wnt target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Tumor suppressor Alpha B-crystallin (CRYAB) associates with the cadherin/catenin adherens junction and impairs NPC progression-associated properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Tcf4 can specifically recognize beta-catenin using alternative conformations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Vitamin D receptor is essential for normal keratinocyte stem cell function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
transcription coactivator activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
1 January 2018
stated in
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IBA
cadherin binding
determination method
HDA
IBA
IEA
IPI
7 references
retrieved
1 January 2018
stated in
Characterization of Cadherin-24, a Novel Alternatively Spliced Type II Cadherin
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IPI
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IBA
retrieved
1 January 2018
stated in
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
HDA
cell component
cytoplasm
determination method
IDA
IEA
12 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
WNT7a induces E-cadherin in lung cancer cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Radixin regulates cell migration and cell-cell adhesion through Rac1
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
nucleus
determination method
IDA
IEA
12 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
catenin complex
determination method
IBA
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
ISS
TAS
IMP
IEA
10 references
retrieved
14 February 2017
stated in
The regulation and deregulation of Wnt signaling by PARK genes in health and disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
TAS
retrieved
14 February 2017
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
TAS
retrieved
14 February 2017
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
ISS
retrieved
14 February 2017
stated in
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IMP
retrieved
14 February 2017
stated in
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IMP
retrieved
14 February 2017
stated in
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IMP
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IEA
retrieved
14 February 2017
stated in
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IDA
retrieved
14 February 2017
stated in
Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IDA
retrieved
14 February 2017
stated in
Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P35222
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IEA
IMP
ISS
TAS
13 references
retrieved
1 January 2018
stated in
The regulation and deregulation of Wnt signaling by PARK genes in health and disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
TAS
retrieved
1 January 2018
stated in
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
ISS
retrieved
1 January 2018
stated in
FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IBA
canonical Wnt signaling pathway
determination method
IDA
IEA
IMP
6 references
retrieved
1 January 2018
stated in
TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IEA
retrieved
1 January 2018
stated in
WNT7a induces E-cadherin in lung cancer cells
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
GOA
curator
UniProt
UniProt protein ID
P35222
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA
retrieved
1 January 2018
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35222
determination method
IDA

Identifiers

MeSH descriptor ID
C495270
subject named as
CTNNB1 protein, human
0 references
Ensembl protein ID
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q1634046&oldid=2022903355"