Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges (Q26744599)

Europe PubMed Central

title

Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges (English)

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1 reference

Claire MacNabb

1

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D Patton

series ordinal

2

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J S Hayes

series ordinal

3

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language of work or name

English

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publication date

2016

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published in

Journal of Osteoporosis

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Creative Commons Attribution 4.0 International

volume

2016

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page(s)

6217286

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copyright license

start time

1 January 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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28 September 2017

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Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

28 September 2017

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The Wnt signaling pathway and bone metabolism

28 September 2017

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28 September 2017

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28 September 2017

1 reference

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Regulation of bone mass by Wnt signaling

28 September 2017

1 reference

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Bone morphogenetic proteins and their antagonists: the sclerostin paradigm.

28 September 2017

1 reference

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Skeletal effects and functional outcome with olpadronate in children with osteogenesis imperfecta: a 2-year randomised placebo-controlled study

28 September 2017

1 reference

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Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review

28 September 2017

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The worldwide problem of osteoporosis: insights afforded by epidemiology

28 September 2017

1 reference

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The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5.

28 September 2017

1 reference

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Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899597

Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength.

31 May 2018

1 reference

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Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

31 May 2018

1 reference

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The socioeconomic burden of fractures: today and in the 21st century

31 May 2018

1 reference

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The natural history of sclerosteosis

31 May 2018

1 reference

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Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells.

21 January 2018

1 reference

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal women with low bone mass: a randomized, double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Romosozumab in postmenopausal women with low bone mineral density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

The Effects of Parathyroid Hormone, Alendronate, or Both in Men with Osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Effects of sclerostin antibody on healing of a non-critical size femoral bone defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Strongly enhanced levels of sclerostin during human fracture healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases

21 January 2018

1 reference

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Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Activation of the Canonical Wnt Signaling Pathway Induces Cementum Regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Sclerostin antibody stimulates bone regeneration after experimental periodontitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy

21 January 2018

1 reference

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A case-control study of calciphylaxis in Japanese end-stage renal disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Sclerostin: another bone-related protein related to all-cause mortality in haemodialysis?

21 January 2018

1 reference

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Expression of sclerostin scFv and the effect of sclerostin scFv on healing of osteoporotic femur fracture in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Adverse Effects of Osteocytic Constitutive Activation of ß-Catenin on Bone Strength and Bone Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Uremic toxicity and sclerostin in chronic kidney disease patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4899597

Time-dependent effects of sclerostin antibody on a mouse fracture healing model

28 November 2018

1 reference

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Intravenous Neridronate in Children With Osteogenesis Imperfecta: A Randomized Controlled Study

28 November 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

21 January 2018

1 reference

12 December 2020

Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety

1 reference

12 December 2020

Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women

1 reference

12 December 2020

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

1 reference

12 December 2020

Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats

1 reference

12 December 2020

Serum sclerostin and adverse outcomes in nondialyzed chronic kidney disease patients

1 reference

12 December 2020

New approaches to the treatment of osteoporosis

1 reference

12 December 2020

Sclerostin antibody treatment enhances metaphyseal bone healing in rats

1 reference

12 December 2020

Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats

1 reference

12 December 2020

Sclerostin antibody prevents particle-induced implant loosening by stimulating bone formation and inhibiting bone resorption in a rat model

1 reference

12 December 2020

Bone matrix quality after sclerostin antibody treatment

1 reference

12 December 2020

High levels of circulating sclerostin are associated with better cardiovascular survival in incident dialysis patients: results from the NECOSAD study

1 reference

12 December 2020

Involvement of the Wnt-β-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis

1 reference

12 December 2020

Matrix Gla-protein: the calcification inhibitor in need of vitamin K

1 reference

12 December 2020

Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: high predictive value of the carboxyterminal propeptide of type I procollagen

1 reference

12 December 2020

Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats

1 reference

12 December 2020

Prevalence of hypercalcemia in hospitalised patients: effects of "correction" for serum albumin values

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F6217286

7 January 2021