Cysteine cathepsins: from structure, function and regulation to new frontiers (Q26860406)

Veronika Stoka

2

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Olga Vasiljeva

3

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Miha Renko

4

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Tao Sun

5

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Boris Turk

6

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Dušan Turk

7

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language of work or name

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January 2012

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Biochimica et Biophysica Acta

published in

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volume

1824

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issue

1

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page(s)

68-88

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Binding mode of CA074, a specific irreversible inhibitor, to bovine cathepsin B as determined by X-ray crystal analysis of the complex

cites work

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12 December 2020

Participation of cathepsin L on bone resorption

1 reference

12 December 2020

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity

1 reference

12 December 2020

Potent inactivation of cathepsins S and L by peptidyl (acyloxy)methyl ketones

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12 December 2020

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

1 reference

12 December 2020

Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease

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12 December 2020

Modulation of hypotensive effects of kinins by cathepsin K.

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12 December 2020

Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions

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12 December 2020

Inactivation of human cystatin C and kininogen by human cathepsin D

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12 December 2020

Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.

1 reference

12 December 2020

Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells

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12 December 2020

Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer

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12 December 2020

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

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12 December 2020

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.

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12 December 2020

Intracellular trafficking of lysosomal proteins and lysosomes

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12 December 2020

Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease

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12 December 2020

Crystal structure of human osteoclast cathepsin K complex with E-64

1 reference

12 December 2020

Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily

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12 December 2020

Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain

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12 December 2020

Cloning a synthetic gene for human stefin B and its expression in E. coli

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12 December 2020

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

1 reference

12 December 2020

Friends and relations of the cystatin superfamily--new members and their evolution

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12 December 2020

Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators

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12 December 2020

Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.

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12 December 2020

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

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12 December 2020

Equistatin, a new inhibitor of cysteine proteinases from Actinia equina, is structurally related to thyroglobulin type-1 domain

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12 December 2020

The cystatins: Protein inhibitors of cysteine proteinases

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12 December 2020

Sorting of non-glycosylated human procathepsin S in mammalian cells

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12 December 2020

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators

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12 December 2020

Equistatin, a protease inhibitor from the sea anemone actinia equina, is composed of three structural and functional domains

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12 December 2020

Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

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12 December 2020

Histone H3 tail clipping regulates gene expression

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12 December 2020

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation

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12 December 2020

Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis

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12 December 2020

Lysosomal cathepsin B: correlation with metastatic potential

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12 December 2020

High-affinity binding of two molecules of cysteine proteinases to low-molecular-weight kininogen.

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12 December 2020

Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis

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12 December 2020

Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.

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12 December 2020

Friends or foes - bipolar effects of the tumour stroma in cancer

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12 December 2020

Autocatalytic processing of recombinant human procathepsin B is a bimolecular process.

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12 December 2020

Role of cathepsin K in normal joints and in the development of arthritis

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12 December 2020

Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes

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12 December 2020

The crystal structure of human cathepsin L complexed with E-64

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12 December 2020

Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B.

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12 December 2020

Evolution of proteins of the cystatin superfamily

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12 December 2020

Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies interfering with their functional properties

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12 December 2020

Mechanisms of amyloid fibril formation--focus on domain-swapping

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts

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12 December 2020

Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding

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12 December 2020

Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases

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12 December 2020

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12 December 2020

Genealogy of mammalian cysteine proteinase inhibitors. Common evolutionary origin of stefins, cystatins and kininogens

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12 December 2020

Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets?

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12 December 2020

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

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12 December 2020

Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen

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12 December 2020

The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain

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12 December 2020

Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators

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12 December 2020

Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft

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12 December 2020

Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain

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12 December 2020

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

12 December 2020

Boophilus microplus cathepsin L-like (BmCL1) cysteine protease: specificity study using a peptide phage display library

1 reference

12 December 2020

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes

1 reference

12 December 2020

Expression of cathepsins B and S in the progression of prostate carcinoma

1 reference

12 December 2020

Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo

1 reference

12 December 2020

Lysosomal cysteine proteases: facts and opportunities

1 reference

12 December 2020

The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B

1 reference

12 December 2020

Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma

1 reference

12 December 2020

Drug delivery strategies for cathepsin inhibitors in joint diseases

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12 December 2020

Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families

1 reference

12 December 2020

Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity

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12 December 2020

Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line

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12 December 2020

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.

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12 December 2020

Conformational Variability of Chicken Cystatin

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12 December 2020

Targeting proteases: successes, failures and future prospects

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12 December 2020

Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.

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12 December 2020

Cathepsins: key modulators of cell death and inflammatory responses

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12 December 2020

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

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12 December 2020

Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors

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12 December 2020

Crystal structure of wild-type human procathepsin K

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12 December 2020

Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice

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12 December 2020

Determination of cathepsins B and H in sera and synovial fluids of patients with different joint diseases

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12 December 2020

S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates

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12 December 2020

Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis

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12 December 2020

Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide.

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12 December 2020

Development of activity-based probes for cathepsin X.

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12 December 2020

Cystatin B: mutation detection, alternative splicing and expression in progressive myclonus epilepsy of Unverricht-Lundborg type (EPM1) patients

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12 December 2020

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

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12 December 2020

Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis

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12 December 2020

Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase

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12 December 2020

Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.

1 reference

12 December 2020

E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions

1 reference

12 December 2020

The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex

1 reference

12 December 2020

Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro

1 reference

12 December 2020

Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.

1 reference

12 December 2020

Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors

1 reference

12 December 2020

Essential role of proline isomerization in stefin B tetramer formation

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12 December 2020

Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo

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12 December 2020

Cysteine cathepsins and the cutting edge of cancer invasion

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12 December 2020

Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin

1 reference

12 December 2020

Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization

1 reference

12 December 2020

Cyclic ketone inhibitors of the cysteine protease cathepsin K.

1 reference

12 December 2020

Cathepsins and cystatin C in atherosclerosis and obesity

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12 December 2020

The crystal structure of human procathepsin K

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12 December 2020

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes.

1 reference

12 December 2020

High-molecular-weight kininogen binds two molecules of cysteine proteinases with different rate constants

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12 December 2020

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

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12 December 2020

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

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12 December 2020

Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.

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12 December 2020

Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions

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12 December 2020

Biochemical properties and regulation of cathepsin K activity

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12 December 2020

Imaging proteolysis by living human breast cancer cells

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12 December 2020

Selective inhibition of the collagenase activity of cathepsin K

1 reference

12 December 2020

Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors

1 reference

12 December 2020

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

1 reference

12 December 2020

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

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12 December 2020

Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation

1 reference

12 December 2020

Selective cysteine protease inhibition contributes to blood-feeding success of the tick Ixodes scapularis.

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12 December 2020

A structural network associated with the kallikrein-kinin and renin-angiotensin systems

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12 December 2020

Cathepsin cysteine proteases in cardiovascular disease.

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12 December 2020

Antiinflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick Ixodes scapularis.

1 reference

12 December 2020

Diverse regulatory roles for lysosomal proteases in the immune response

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12 December 2020

The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression

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12 December 2020

Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B.

1 reference

12 December 2020

Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases

1 reference

12 December 2020

Cysteine cathepsins: multifunctional enzymes in cancer

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12 December 2020

Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases

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12 December 2020

Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro

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12 December 2020

Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption

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12 December 2020

Protein inhibitors of cysteine proteinases. III. Amino-acid sequence of cystatin from chicken egg white

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12 December 2020

Human and mouse proteases: a comparative genomic approach

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12 December 2020

Inhibition of bone resorption by selective inactivators of cysteine proteinases

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12 December 2020

Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation

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12 December 2020

Collagenolytic cathepsins of rabbit spleen: a kinetic analysis of collagen degradation and inhibition by chicken cystatin

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12 December 2020

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

1 reference

12 December 2020

Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases

1 reference

12 December 2020

Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.

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12 December 2020

Localization of DNA sequences governing alternative mRNA production of rat kininogen genes

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12 December 2020

Interaction of chicken cystatin with inactivated papains

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12 December 2020

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12 December 2020

Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids

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12 December 2020

Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype

1 reference

12 December 2020

A fragment of the major histocompatibility complex class II-associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruzi

1 reference

12 December 2020

Kinetics of the pH-induced inactivation of human cathepsin L

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12 December 2020

Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor

1 reference

12 December 2020

Mechanism of inhibition of papain by chicken egg white cystatin. Inhibition constants of N-terminally truncated forms and cyanogen bromide fragments of the inhibitor

1 reference

12 December 2020

Structure and functions of human kininogens

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12 December 2020

Human cathepsin B is a metastable enzyme stabilized by specific ionic interactions associated with the active site

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12 December 2020

Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation

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12 December 2020

Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee

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12 December 2020

The combined action of two enzymes in human serum can mimic the activity of cathepsin B.

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12 December 2020

Proteolysis in MHC class II antigen presentation: who's in charge?

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12 December 2020

Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo

1 reference

12 December 2020

Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase

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12 December 2020

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.

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12 December 2020

Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L.

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12 December 2020

Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine

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12 December 2020

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12 December 2020

Cathepsin L activity controls adipogenesis and glucose tolerance

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12 December 2020

The inhibition of cathepsin S by its propeptide--specificity and mechanism of action

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12 December 2020

Evolutionary families of peptidase inhibitors

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12 December 2020

Lysosomal cysteine cathepsins: signaling pathways in apoptosis

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12 December 2020

Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas

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12 December 2020

Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival

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12 December 2020

Regulation of proteolytic activity in tissues

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12 December 2020

Revised definition of substrate binding sites of papain-like cysteine proteases

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12 December 2020

Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship

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12 December 2020

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

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12 December 2020

Biosynthesis of leupeptin

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12 December 2020

Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates

1 reference

12 December 2020

Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen

1 reference

12 December 2020

Conformational flexibility and allosteric regulation of cathepsin K.

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12 December 2020

Cysteine proteinases and their inhibitors in extracellular fluids: markers for diagnosis and prognosis in cancer.

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12 December 2020

Cathepsin L increases invasion and migration of B16 melanoma

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12 December 2020

Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.

1 reference

12 December 2020

Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomes

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12 December 2020

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA)

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12 December 2020

Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.

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12 December 2020

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

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12 December 2020

Modification of S1 subsite specificity in the cysteine protease cathepsin B.

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12 December 2020

Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease

1 reference

12 December 2020

The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors

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12 December 2020

High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells

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12 December 2020

Cysteine cathepsins in the immune response

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12 December 2020

Cysteine cathepsins (proteases)--on the main stage of cancer?

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12 December 2020

Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells

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12 December 2020

Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs

1 reference

12 December 2020

Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L

1 reference

12 December 2020

Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate

1 reference

12 December 2020

Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases

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12 December 2020

Neuronal ceroid lipofuscinoses

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12 December 2020

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.

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12 December 2020

Human cathepsin X: A cysteine protease with unique carboxypeptidase activity

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12 December 2020

Acidic pH as a physiological regulator of human cathepsin L activity.

1 reference

12 December 2020

Proteases: multifunctional enzymes in life and disease

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12 December 2020

Serum cathepsin-B levels and urinary-excretion of cathepsin-B in the patients with colorectal-cancer - possible indicators for tumor malignancy

1 reference

12 December 2020

Irreversible inhibitors of serine, cysteine, and threonine proteases

1 reference

12 December 2020

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells

1 reference

12 December 2020

Azepanone-based inhibitors of human cathepsin S: optimization of selectivity via the P2 substituent

1 reference

12 December 2020

Cathepsins and their involvement in immune responses

1 reference

12 December 2020

Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer

1 reference

12 December 2020

Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex

1 reference

12 December 2020

Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.

1 reference

12 December 2020

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

1 reference

12 December 2020

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

1 reference

12 December 2020

Cathepsin X binds to cell surface heparan sulfate proteoglycans

1 reference

12 December 2020

Lysosomes as "suicide bags" in cell death: myth or reality?

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12 December 2020

Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides

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12 December 2020

The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics

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12 December 2020

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases

1 reference

12 December 2020

Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing

1 reference

12 December 2020

A new subgroup of the family 2 cystatins

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12 December 2020

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

1 reference

12 December 2020

Lysosomal cysteine proteases: structural features and their role in apoptosis

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12 December 2020

Destabilizing role of cathepsin S in murine atherosclerotic plaques

1 reference

12 December 2020

Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney

1 reference

12 December 2020

Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi.

1 reference

12 December 2020

RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties

1 reference

12 December 2020

Serum cysteine proteases and their inhibitors in rheumatoid arthritis: relation to disease activity and radiographic progression

1 reference

12 December 2020

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

1 reference

12 December 2020

Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme

1 reference

12 December 2020

Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function

1 reference

12 December 2020

Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro

1 reference

12 December 2020

Crystal structure of human cathepsin K complexed with a potent inhibitor

1 reference

12 December 2020

The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases

1 reference

12 December 2020

Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation

1 reference

12 December 2020

Cystatins: biochemical and structural properties, and medical relevance

1 reference

12 December 2020

Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location

1 reference

12 December 2020

E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group

1 reference

12 December 2020

Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

1 reference

12 December 2020

Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide

1 reference

12 December 2020

Stefin B interacts with histones and cathepsin L in the nucleus

1 reference

12 December 2020

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

1 reference

12 December 2020

Emerging role of cathepsin S in obesity and its associated diseases

1 reference

12 December 2020

Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.

1 reference

12 December 2020

Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.

1 reference

12 December 2020

Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?

1 reference

12 December 2020

Dual contrasting roles of cysteine cathepsins in cancer progression: apoptosis versus tumour invasion.

1 reference

12 December 2020

Imaging proteolysis by living human glioma cells

1 reference

12 December 2020

Bovine stefin C, a new member of the stefin family

1 reference

12 December 2020

Falcipains and other cysteine proteases of malaria parasites

1 reference

12 December 2020

Cathepsins B, H and L in human breast carcinoma

1 reference

12 December 2020

The endosome-lysosome pathway and information generation in the immune system

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12 December 2020

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12 December 2020

uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.

1 reference

12 December 2020

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

1 reference

12 December 2020

Cystatin C modulates cerebral beta-amyloidosis

1 reference

12 December 2020

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

1 reference

12 December 2020

Glycosaminoglycans facilitate procathepsin B activation through disruption of propeptide-mature enzyme interactions

1 reference

12 December 2020

Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases

1 reference

12 December 2020

Peptidase inhibitors in the MEROPS database

1 reference

12 December 2020

Structure of papain refined at 1.65 A resolution

1 reference

12 December 2020

MEROPS: the peptidase database

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12 December 2020

Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity

1 reference

12 December 2020

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

1 reference

12 December 2020

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

1 reference

12 December 2020

Cathepsin K: a cysteine protease with unique kinin-degrading properties

1 reference

12 December 2020

Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms

1 reference

12 December 2020

Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems

1 reference

12 December 2020

Specialized roles for cysteine cathepsins in health and disease.

1 reference

12 December 2020

The lysosome turns fifty

1 reference

12 December 2020

Cystatins of parasitic organisms

1 reference

12 December 2020

Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping

1 reference

12 December 2020

Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.

1 reference

12 December 2020

Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity

1 reference

12 December 2020

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

1 reference

12 December 2020

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

1 reference

12 December 2020

Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D.

1 reference

12 December 2020

How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics

1 reference

12 December 2020

Delivering nanomedicine to solid tumors

1 reference

12 December 2020

Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease

1 reference

12 December 2020

Cysteine cathepsins: cellular roadmap to different functions

1 reference

12 December 2020

The discovery of lysosomes

1 reference

12 December 2020

Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrate

1 reference

12 December 2020

Calpain inhibition by peptide epoxides

1 reference

12 December 2020

Phylogenomic analysis of the cystatin superfamily in eukaryotes and prokaryotes

1 reference

12 December 2020

Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin

1 reference

12 December 2020

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

1 reference

12 December 2020

Invariant chain structure and MHC class II function

1 reference

12 December 2020

An intracellular form of cathepsin B contributes to invasiveness in cancer.

1 reference

12 December 2020

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones

1 reference

12 December 2020

Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes.

1 reference

12 December 2020

Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor

1 reference

12 December 2020

Comprehensive search for cysteine cathepsins in the human genome

1 reference

12 December 2020

Kininogens: More than cysteine protease inhibitors and kinin precursors

1 reference

12 December 2020

Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)

1 reference

12 December 2020

Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin.

1 reference

12 December 2020

Protease signalling in cell death: caspases versus cysteine cathepsins.

1 reference

12 December 2020

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

1 reference

12 December 2020

The lysosomal cysteine proteases in MHC class II antigen presentation

1 reference

12 December 2020

Functions of Propeptide Parts in Cysteine Proteases

1 reference

12 December 2020

Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B.

1 reference

12 December 2020

Dipeptidyl nitrile inhibitors of Cathepsin L

1 reference

12 December 2020

Thyropins--new structurally related proteinase inhibitors.

1 reference

12 December 2020

Regulation of collagenase activities of human cathepsins by glycosaminoglycans

1 reference

12 December 2020

Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C).

1 reference

12 December 2020

The molecular understanding of osteoclast differentiation

1 reference

12 December 2020

Potent slow-binding inhibition of cathepsin B by its propeptide

1 reference

12 December 2020

Structural organization of the human kininogen gene and a model for its evolution

1 reference

12 December 2020

The proteome of lysosomes

1 reference

12 December 2020

Dynamic imaging of protease activity with fluorescently quenched activity-based probes.

1 reference

12 December 2020

Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization

1 reference

12 December 2020

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

1 reference

12 December 2020

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

1 reference

12 December 2020

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

1 reference

12 December 2020

Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors

1 reference

12 December 2020

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

1 reference

12 December 2020

Cysteine cathepsins in human cancer

1 reference

12 December 2020

The S2 subsites of cathepsins K and L and their contribution to collagen degradation

1 reference

12 December 2020

Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients

1 reference

12 December 2020

Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes

1 reference

12 December 2020

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation

1 reference

12 December 2020

Hereditary cystatin C amyloid angiopathy

1 reference

12 December 2020

MEROPS: the peptidase database

1 reference

12 December 2020

Crystal structure of human cathepsin V

1 reference

12 December 2020

Human cystatin, a new protein inhibitor of cysteine proteinases

1 reference

12 December 2020

Autocatalytic activation of human cathepsin K.

1 reference

12 December 2020

Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes

1 reference

12 December 2020

Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis

1 reference

12 December 2020

Molecular genetics of the NCLs -- status and perspectives

1 reference

12 December 2020

Structural basis for the recognition and cleavage of histone H3 by cathepsin L

1 reference

12 December 2020

The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction

1 reference

12 December 2020

Structure of a Cys25-->Ser mutant of human cathepsin S

1 reference

12 December 2020

Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymes

1 reference

12 December 2020

Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases

1 reference

12 December 2020

Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion

1 reference

12 December 2020

Multifunctional Roles for Serum Protein Fetuin-A in Inhibition of Human Vascular Smooth Muscle Cell Calcification

1 reference

12 December 2020

Two distinct gene subfamilies within the family of cysteine protease genes

1 reference

12 December 2020

Probing cathepsin K activity with a selective substrate spanning its active site.

1 reference

12 December 2020

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

1 reference

12 December 2020

The three-dimensional solution structure of human stefin A

1 reference

12 December 2020

Molecular cloning and sequence analysis of human preprocathepsin C

1 reference

12 December 2020

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

1 reference

12 December 2020

On the size of the active site in proteases. I. Papain

1 reference

12 December 2020

Selective activity-based probes for cysteine cathepsins

1 reference

12 December 2020

Lysosomal cysteine proteases: more than scavengers

1 reference

12 December 2020

The occluding loop of cathepsin B prevents its effective inhibition by human kininogens.

1 reference

12 December 2020

Cathepsin B-like activity as a serum tumour marker in ovarian carcinoma

1 reference

12 December 2020

Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasis

1 reference

12 December 2020

pH-induced conformational transitions of the propeptide of human cathepsin L. A role for a molten globule state in zymogen activation

1 reference

12 December 2020

Functional involvement of cathepsin W in the cytotoxic activity of NK‐92 cells

1 reference

12 December 2020

Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins

1 reference

12 December 2020

Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications

1 reference

12 December 2020

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

1 reference

12 December 2020

Protease degradomics: a new challenge for proteomics

1 reference

12 December 2020

Recombinant human procathepsin S is capable of autocatalytic processing at neutral pH in the presence of glycosaminoglycans

1 reference

12 December 2020

Kinetics of inhibition of bovine cathepsin S by bovine stefin B

1 reference

12 December 2020

Role of the occluding loop in cathepsin B activity

1 reference

12 December 2020

The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents

1 reference

12 December 2020

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

1 reference

12 December 2020

Development of nitrile-based peptidic inhibitors of cysteine cathepsins

1 reference

12 December 2020

Two decades of thyroglobulin type-1 domain research.

1 reference

12 December 2020

10.1016/J.BBAPAP.2011.10.002

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

release_3kobyvwwwvdoxmygzeeakgyg3e

456691

Fatcat ID

0 references

456691

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

0 references

1 reference