The pharmacological landscape and therapeutic potential of serine hydrolases (Q26995817)

language of work or name

1 reference

3 January 2012

1 reference

Nature Reviews Drug Discovery

published in

1 reference

volume

11

1 reference

issue

1

1 reference

page(s)

52-68

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Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

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Structure of malonamidase E2 reveals a novel Ser-cisSer-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature

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Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers

21 March 2017

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

21 March 2017

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Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation

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8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

21 March 2017

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21 March 2017

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21 March 2017

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Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

21 March 2017

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Structure-based design of novel potent nonpeptide thrombin inhibitors

21 March 2017

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Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

21 March 2017

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Site-directed ligand discovery

21 March 2017

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 March 2017

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S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies

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Too many roads not taken

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Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

21 March 2017

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Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers

21 March 2017

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Gut peptides in the regulation of food intake and energy homeostasis

21 March 2017

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Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor

21 March 2017

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Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

21 March 2017

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Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth

21 March 2017

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

21 March 2017

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The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme

21 March 2017

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The cholinergic hypothesis of geriatric memory dysfunction

21 March 2017

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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 March 2017

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21 March 2017

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 March 2017

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Modulation of anxiety through blockade of anandamide hydrolysis

7 April 2017

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7 April 2017

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Structural basis of substrate specificity in the serine proteases

7 April 2017

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Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer

7 April 2017

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28 September 2017

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28 September 2017

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Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010.

28 September 2017

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28 September 2017

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The resurgence of covalent drugs

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Quantitative reactivity profiling predicts functional cysteines in proteomes

28 September 2017

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

28 September 2017

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28 September 2017

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Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

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Triggers, targets and treatments for thrombosis

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28 September 2017

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Activity-based probes for proteomic profiling of histone deacetylase complexes

28 September 2017

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Functional interrogation of the kinome using nucleotide acyl phosphates

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Human pancreatic digestive enzymes

28 September 2017

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28 September 2017

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An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

28 September 2017

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The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema

28 September 2017

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Mechanism-based profiling of enzyme families

28 September 2017

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28 September 2017

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Mass spectrometry and protein analysis

28 September 2017

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Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation

28 September 2017

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Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

28 September 2017

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Development of activity-based probes for trypsin-family serine proteases

28 September 2017

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Lipoprotein-associated phospholipase A2: a potential therapeutic target for atherosclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Activity-based probes that target diverse cysteine protease families

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Serine hydrolase targets of organophosphorus toxicants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Targeting acetylcholinesterase and butyrylcholinesterase in dementia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Cholinesterase inhibitors in the treatment of dementia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Discovering disease-associated enzymes by proteome reactivity profiling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Inhibitors of Tissue Factor. Factor VIIa for anticoagulant therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

A new oral anticoagulant: the 50-year challenge

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Triacylglycerol hydrolase: role in intracellular lipid metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Mass spectral analysis in proteomics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Tethering: fragment-based drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Prolyl peptidases: a serine protease subfamily with high potential for drug discovery.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Engineering of a macromolecular scaffold to develop specific protease inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

An overview of the direct thrombin inhibitor argatroban

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Cholinesterases: new roles in brain function and in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Proteomics: the first decade and beyond

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Endothelial lipase is a major determinant of HDL level

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Gastric inhibitory polypeptide: the neglected incretin revisited

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Chemical approaches for functionally probing the proteome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Fondaparinux, a synthetic pentasaccharide: the first in a new class of antithrombotic agents - the selective factor Xa inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Bivalirudin: an anticoagulant for acute coronary syndromes and coronary interventions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Biological actions and therapeutic potential of the glucagon-like peptides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The plasminogen activation system in tumor growth, invasion, and metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Activity-based protein profiling: the serine hydrolases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The pharmacology of galanthamine and its analogues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Glucagon-like peptide-1 and control of insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Kunitz domain inhibitors of tissue factor-factor VIIa. II. Potent and specific inhibitors by competitive phage selection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The development of hirudin as an antithrombotic drug

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

ONO-5046, a novel inhibitor of human neutrophil elastase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Mechanism of inhibition of LDL phospholipase A2 by monocyclic-beta-lactams. Burst kinetics and the effect of stereochemistry

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The rationale for E2020 as a potent acetylcholinesterase inhibitor.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The anticholinesterase activity of physostigmine

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Selective loss of central cholinergic neurons in Alzheimer's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

The metabolic serine hydrolases and their functions in mammalian physiology and disease

31 May 2018

1 reference

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

21 January 2018

1 reference

Genomic overview of serine proteases

21 January 2018

1 reference

21 January 2018

1 reference

Clarification of mechanism of human sputum elastase inhibition by a new inhibitor, ONO-5046, using electrospray ionization mass spectrometry

21 January 2018

1 reference

HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism

21 January 2018

1 reference

Carbapenems: past, present, and future

21 January 2018

1 reference

The future of the β-lactams.

21 January 2018

1 reference

Therapeutics: new drugs hit the target

21 January 2018

1 reference

YM-60828, a novel factor Xa inhibitor: Separation of its antithrombotic effects from its prolongation of bleeding time

21 January 2018

1 reference

Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants

21 January 2018

1 reference

Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020).

21 January 2018

1 reference

Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo.

21 January 2018

1 reference

Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans.

21 January 2018

1 reference

1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

21 January 2018

1 reference

Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors

21 January 2018

1 reference

(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

21 January 2018

1 reference

Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors

21 January 2018

1 reference

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

21 January 2018

1 reference

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

21 January 2018

1 reference

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

21 January 2018

1 reference

Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

21 January 2018

1 reference

Fatty acid amide hydrolase inhibitors--progress and potential

21 January 2018

1 reference

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor

21 January 2018

1 reference

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

21 January 2018

1 reference

Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity

21 January 2018

1 reference

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors

21 January 2018

1 reference

Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys

21 January 2018

1 reference

Translational research on prolyl oligopeptidase inhibitors: the long road ahead.

21 January 2018

1 reference

Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft

21 January 2018

1 reference

PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism.

21 January 2018

1 reference

A streamlined platform for high-content functional proteomics of primary human specimens

21 January 2018

1 reference

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

21 January 2018

1 reference

Profiling serine hydrolase activities in complex proteomes

21 January 2018

1 reference

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

21 January 2018

1 reference

Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine

21 January 2018

1 reference

DIALIGN-TX: greedy and progressive approaches for segment-based multiple sequence alignment

21 January 2018

1 reference

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

21 January 2018

1 reference

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

21 January 2018

1 reference

Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665514

Aminoacylpyrrolidine-2-nitriles: potent and stable inhibitors of dipeptidyl-peptidase IV (CD 26)

28 November 2018

1 reference

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

31 March 2020

1 reference

Mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa(activated plasma thromboplastin antecedent)

31 March 2020

1 reference

Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa

31 March 2020

1 reference

Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans

31 March 2020

1 reference

Kinetics of dipeptidyl peptidase IV proteolysis of growth hormone-releasing factor and analogs

31 March 2020

1 reference

Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV

31 March 2020

1 reference

NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV

31 March 2020

1 reference

Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group

31 March 2020

1 reference

Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein

31 March 2020

1 reference

2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2

31 March 2020

1 reference

Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors

31 March 2020

1 reference

Purification and characterization of a porcine liver microsomal triacylglycerol hydrolase

31 March 2020

1 reference

Distribution of post-proline cleaving enzyme in human brain and the peripheral tissues

31 March 2020

1 reference

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats

31 March 2020

1 reference

Rapid identification of potent nonpeptidic serine protease inhibitors

31 March 2020

1 reference

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles

31 March 2020

1 reference

The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase

31 March 2020

1 reference

12 December 2020

Characterization of the lipolytic activity of endothelial lipase

1 reference

12 December 2020

Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin

1 reference

12 December 2020

The amino acid sequence of antistasin. A potent inhibitor of factor Xa reveals a repeated internal structure

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3620

1 reference

Dimensions Publication ID

1048211989

0 references

Fatcat ID

release_bstvh5tj6va4zdyiafxrgzojpu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bstvh5tj6va4zdyiafxrgzojpu

24 November 2022

mapped directly with Wikidata item

1 reference

1 reference

PubMed publication ID

22212679

1 reference