The mitochondrial serine protease HtrA2/Omi: an overview (Q28263602)

Cell Death & Differentiation

Europe PubMed Central

title

The mitochondrial serine protease HtrA2/Omi: an overview (English)

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P Vandenabeele

3

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author name string

L Vande Walle

series ordinal

1

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M Lamkanfi

series ordinal

2

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language of work or name

English

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publication date

March 2008

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published in

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volume

15

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issue

3

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page(s)

453-60

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cites work

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On the origin of mitosing cells

21 April 2017

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

21 April 2017

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima

21 April 2017

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 April 2017

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 April 2017

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Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

21 April 2017

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

21 April 2017

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 April 2017

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Expression, purification, and functional analysis of the human serine protease HtrA2

21 April 2017

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 April 2017

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The role of human HtrA1 in arthritic disease

21 April 2017

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Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

21 April 2017

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Implications of the serine protease HtrA1 in amyloid precursor protein processing

21 April 2017

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A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

21 April 2017

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The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer

21 April 2017

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HTRA1 promoter polymorphism in wet age-related macular degeneration

21 April 2017

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

21 April 2017

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Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme

21 April 2017

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 April 2017

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Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 April 2017

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Presenilin-1 is located in rat mitochondria

21 April 2017

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Proteome-wide Identification of HtrA2/Omi Substrates

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

21 April 2017

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 April 2017

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Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

21 April 2017

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The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

21 April 2017

1 reference

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

21 April 2017

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Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

21 April 2017

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The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

21 April 2017

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 April 2017

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Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 April 2017

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 April 2017

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The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402291

GRIM-19 associates with the serine protease HtrA2 for promoting cell death

21 April 2017

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https://api.crossref.org/works/10.1038/SJ.CDD.4402291

GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I)

21 April 2017

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GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I

21 April 2017

1 reference

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Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402291

CREB is a regulatory target for the protein kinase Akt/PKB

21 April 2017

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Regulation of cell death protease caspase-9 by phosphorylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402291

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 April 2017

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 April 2017

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Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

21 April 2017

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The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum

21 April 2017

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Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

21 April 2017

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The HtrA family of serine proteases

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Origin and evolution of eukaryotic apoptosis: the bacterial connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

A web-accessible complete transcriptome of normal human and DMD muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Structural analysis of DegS, a stress sensor of the bacterial periplasm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

IAPs--the ubiquitin connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Characterization of XIAP-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

RETRACTED: Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402291

7 January 2021