SIRT3 substrate specificity determined by peptide arrays and machine learning (Q33718384)

28 July 2017

title

SIRT3 substrate specificity determined by peptide arrays and machine learning (English)

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28 July 2017

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1

Brian C Smith

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28 July 2017

Burr Settles

2

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28 July 2017

William C Hallows

series ordinal

3

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28 July 2017

Mark W Craven

series ordinal

4

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28 July 2017

John M Denu

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5

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28 July 2017

publication date

1 November 2010

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28 July 2017

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28 July 2017

volume

6

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28 July 2017

issue

2

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28 July 2017

page(s)

146-157

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Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

28 July 2017

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21 June 2018

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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

21 June 2018

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21 June 2018

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Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

21 June 2018

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21 June 2018

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Protein lysine methyltransferase G9a acts on non-histone targets

21 June 2018

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 June 2018

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Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays

21 June 2018

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The human SIRT3 protein deacetylase is exclusively mitochondrial

21 June 2018

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

21 June 2018

1 reference

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Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion

21 June 2018

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Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

21 June 2018

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Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

21 June 2018

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21 June 2018

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21 June 2018

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

21 June 2018

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

21 June 2018

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21 June 2018

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21 June 2018

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

21 June 2018

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SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

21 June 2018

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21 June 2018

1 reference

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Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases

21 June 2018

1 reference

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Structure and Substrate Binding Properties of cobB, a Sir2 Homolog Protein Deacetylase from Escherichia coli

21 June 2018

1 reference

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Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2′-O-Acetyl ADP Ribose and Histone Peptide

21 June 2018

1 reference

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 June 2018

1 reference

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Structure of a Sir2 enzyme bound to an acetylated p53 peptide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Acetylation: a regulatory modification to rival phosphorylation?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

The hydrophobic effect in protein folding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Hydrophobicity of amino acid residues in globular proteins.

21 June 2018

1 reference

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An algorithm for protein secondary structure prediction based on class prediction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Calculation of protein extinction coefficients from amino acid sequence data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 June 2018

1 reference

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Surface and inside volumes in globular proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Antiparallel and parallel β-strands differ in amino acid residue preferences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Affinity profiling using the peptide microarray technology: a case study.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Unstructured conformations are a substrate requirement for the Sir2 family of NAD-dependent protein deacetylases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

SPOT synthesis: reliability of array-based measurement of peptide binding affinity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD+ and Acetylated Peptide

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

The Structural Basis of Sirtuin Substrate Affinity†,‡

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042044

30 October 2018

Identifiers

DOI

10.1021/CB100218D

1 reference

28 July 2017

1 reference

28 July 2017

1 reference