From monogenic to polygenic obesity: recent advances (Q33731455)

29 July 2017

10 references

19 March 2019

24 March 2019

22 April 2019

19 June 2019

20 August 2019

23 July 2020

10 September 2020

29 November 2020

18 December 2020

26 January 2021

From monogenic to polygenic obesity: recent advances (English)

1 reference

29 July 2017

6 references

19 March 2019

24 March 2019

22 April 2019

19 June 2019

20 August 2019

23 July 2020

5 references

19 March 2019

24 March 2019

22 April 2019

19 June 2019

20 August 2019

physiological phenomenon

1 reference

genetic predisposition to disease

20 August 2019

2 references

23 July 2020

10 September 2020

2 references

29 November 2020

26 January 2021

multifactorial inheritance

1 reference

18 December 2020

1

Anke Hinney

0 references

Johannes Hebebrand

series ordinal

3

object named as

Johannes Hebebrand

0 references

author name string

Carla I G Vogel

series ordinal

2

1 reference

29 July 2017

3 February 2010

1 reference

PubMed ID

20127379

European Child & Adolescent Psychiatry

29 July 2017

1 March 2010

9 references

19 March 2019

24 March 2019

22 April 2019

19 June 2019

20 August 2019

23 July 2020

29 November 2020

18 December 2020

26 January 2021

10 references

29 July 2017

19 March 2019

24 March 2019

22 April 2019

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20 August 2019

23 July 2020

29 November 2020

18 December 2020

26 January 2021

19

1 reference

29 July 2017

297-310

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29 July 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1007/s00787-010-0096-6

29 July 2017

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14 July 2018

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FTO genotype and the weight loss benefits of moderate intensity exercise

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

14 July 2018

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Gene-environment interactions and obesity--further aspects of genomewide association studies

14 July 2018

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Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

14 July 2018

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Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations

14 July 2018

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The effect of neurohormonal factors, epigenetic factors, and gut microbiota on risk of obesity.

14 July 2018

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The genetic contribution to non-syndromic human obesity

14 July 2018

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14 July 2018

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Inactivation of the Fto gene protects from obesity

14 July 2018

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Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

14 July 2018

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Leptin: a pivotal regulator of human energy homeostasis

14 July 2018

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Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

14 July 2018

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14 July 2018

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Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

14 July 2018

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

14 July 2018

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Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

14 July 2018

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An obesity-associated FTO gene variant and increased energy intake in children

14 July 2018

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Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes

14 July 2018

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14 July 2018

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'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

14 July 2018

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Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity

14 July 2018

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Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

14 July 2018

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The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women

14 July 2018

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Obesity associated genetic variation in FTO is associated with diminished satiety

14 July 2018

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Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure

14 July 2018

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Common variants near MC4R are associated with fat mass, weight and risk of obesity

14 July 2018

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Regulation of Fto/Ftm gene expression in mice and humans

14 July 2018

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14 July 2018

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Insights from the genetics of severe childhood obesity

14 July 2018

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Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

14 July 2018

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The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily

14 July 2018

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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

14 July 2018

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

14 July 2018

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Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

14 July 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

14 July 2018

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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

14 July 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

14 July 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

14 July 2018

1 reference

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The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

14 July 2018

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Comment on "A common genetic variant is associated with adult and childhood obesity"

14 July 2018

1 reference

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Genetics of Obesity in Humans

14 July 2018

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Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist

14 July 2018

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The human obesity gene map: the 2005 update

14 July 2018

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Epigenetic differences arise during the lifetime of monozygotic twins

14 July 2018

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Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity.

14 July 2018

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Early life risk factors for obesity in childhood: cohort study

14 July 2018

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Monogenic obesity in humans

14 July 2018

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Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

14 July 2018

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Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

14 July 2018

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Melanocortin-4 receptor gene variant I103 is negatively associated with obesity

14 July 2018

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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

14 July 2018

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Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

14 July 2018

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Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity

14 July 2018

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Perspectives: molecular genetic research in human obesity

14 July 2018

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Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

14 July 2018

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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

14 July 2018

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Modifiers of risk of hereditary breast and ovarian cancer

14 July 2018

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

14 July 2018

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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

14 July 2018

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Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

14 July 2018

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Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

14 July 2018

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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

14 July 2018

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

14 July 2018

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

14 July 2018

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

14 July 2018

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

14 July 2018

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Heritable variation in food preferences and their contribution to obesity

14 July 2018

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Genetic and environmental factors in relative body weight and human adiposity

14 July 2018

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

14 July 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

14 July 2018

1 reference

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

14 July 2018

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Genetic dissection of complex traits

14 July 2018

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Positional cloning of the mouse obese gene and its human homologue

14 July 2018

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A unified model for complex segregation analysis

14 July 2018

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An Adoption Study of Human Obesity

14 July 2018

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Genetic and environmental variation in the birth weight of twins

14 July 2018

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Socioeconomic status and obesity: A review of the literature

14 July 2018

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Nutrition, growth, development, and maturation: findings from the ten-state nutrition survey of 1968-1970

14 July 2018

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Obesity in childhood and personality development. 1941.

14 July 2018

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Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults

21 January 2018

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Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort study.

30 October 2018

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Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

30 October 2018

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30 October 2018

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FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity

30 October 2018

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Diagnostic issues in eating disorders and obesity.

30 October 2018

1 reference

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Increasing heritability of BMI and stronger associations with the FTO gene over childhood.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Monogenic human obesity syndromes.

30 October 2018

1 reference

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A common genetic variant is associated with adult and childhood obesity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Influence of the home environment on the development of obesity in children

30 October 2018

1 reference

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A leptin missense mutation associated with hypogonadism and morbid obesity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Obesity and socioeconomic status--a complex relation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Meta-Analysis of Genome-wide Linkage Studies in BMI and Obesity*

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene

30 October 2018

1 reference

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Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

A Quantitative Trait Locus on Chromosome 18q for Physical Activity and Dietary Intake in Hispanic Children*

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

Familial resemblance of body mass index and familial risk of high and low body mass index. A study of young men in Sweden

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

The Body-Mass Index of Twins Who Have Been Reared Apart

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839509

30 October 2018

1 reference

12 December 2020

Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals

1 reference

12 December 2020

Genetic and environmental influences on level of habitual physical activity and exercise participation

1 reference

12 December 2020

The response to long-term overfeeding in identical twins

1 reference

12 December 2020

Genetic influences on eating attitudes in a normal female twin population

1 reference

12 December 2020

Parental neglect during childhood and increased risk of obesity in young adulthood

1 reference

12 December 2020

Characteristics of children selecting low-fat foods in an elementary school lunch program

1 reference

12 December 2020

Epidemic obesity: are genetic factors involved via increased rates of assortative mating?

1 reference

12 December 2020

Distribution and heritability of BMI in Finnish adolescents aged 16y and 17y: a study of 4884 twins and 2509 singletons

1 reference

12 December 2020

PSYCHOLOGICAL ASPECTS OF OVEREATING AND OBESITY

1 reference

12 December 2020

Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity

1 reference

12 December 2020

As obesity rates rise, experts struggle to explain why

1 reference

12 December 2020

Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans

1 reference

12 December 2020

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

12 December 2020

10.1007/S00787-010-0096-6

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

PubMed ID

20127379