Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA. (Q33814333)

29 July 2017

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title

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA. (English)

1 reference

29 July 2017

Yan Xu

1

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29 July 2017

publication date

7 February 2011

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29 July 2017

published in

Chemical Society Reviews

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29 July 2017

volume

40

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29 July 2017

issue

5

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29 July 2017

page(s)

2719-2740

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The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis

29 July 2017

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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Telomere maintenance and disease

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold

21 January 2018

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Structure of a human telomeric DNA sequence stabilized by 8-bromoguanosine substitutions, as determined by NMR in a K+ solution

21 January 2018

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Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution

21 January 2018

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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution

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Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences

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The tail of the telomere

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Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions

21 January 2018

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Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer

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Extreme conformational diversity in human telomeric DNA

21 January 2018

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Covalent ligation studies on the human telomere quadruplex

21 January 2018

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Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

21 January 2018

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Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole.

21 January 2018

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Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.

21 January 2018

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Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet

21 January 2018

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In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

21 January 2018

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Protecting the terminus: t-loops and telomere end-binding proteins

21 January 2018

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Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix

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A mammalian factor that binds telomeric TTAGGG repeats in vitro

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TRF1 is a dimer and bends telomeric DNA

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Telomeric localization of TRF2, a novel human telobox protein

21 January 2018

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins

21 January 2018

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How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures

21 January 2018

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Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2

21 January 2018

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Solution structure of a telomeric DNA complex of human TRF1

21 January 2018

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Identification of human Rap1: implications for telomere evolution

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Purification of proteins associated with specific genomic Loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomere attrition and Chk2 activation in human heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Chromosomal instability in ulcerative colitis is related to telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Heterozygous telomerase RNA mutations found in dyskeratosis congenita and aplastic anemia reduce telomerase activity via haploinsufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomere dynamics in Fancg-deficient mouse and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Human diseases of telomerase dysfunction: insights into tissue aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase induction in T cells: a cure for aging and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Protein composition of catalytically active human telomerase from immortal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The structure and function of telomerase reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A highly selective telomerase inhibitor limiting human cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Development of novel telomerase inhibitors based on a bisindole unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Potent Inhibition of Human Telomerase by Nitrostyrene Derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Potent inhibition of human telomerase by helenalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibitors identified by a forward chemical genetics approach using a yeast strain with shortened telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1/CIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of telomerase with human telomerase reverse transcriptase antisense increases the sensitivity of tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of human telomerase by 2'-O-methyl-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of telomerase by 2'-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Treatment of bladder cancer cells in vitro and in vivo with 2-5A antisense telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibitors--oligonucleotide phosphoramidates as potential therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of human telomerase activity by peptide nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase immunity from bench to bedside: round one.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Using natural product inhibitors to validate Hsp90 as a molecular target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Inhibition of telomerase by G-quartet DNA structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A hitchhiker's guide to G-quadruplex ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Interaction of metal complexes with G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

G-quadruplexes: targets in anticancer drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Antitumour polycyclic acridines. Palladium(0) mediated syntheses of quino[4,3,2-kl]acridines bearing peripheral substituents as potential telomere maintenance inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Structural basis of DNA quadruplex recognition by an acridine drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Biopharmaceutical characterization of the telomerase inhibitor BRACO19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Mechanism of acridine-based telomerase inhibition and telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Structural basis for binding of porphyrin to human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Guanidinium-modified phthalocyanines as high-affinity G-quadruplex fluorescent probes and transcriptional regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Interaction of telomestatin with the telomeric single-strand overhang.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Furan based cyclic oligopeptides selectively target G-quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Cyclo[n]pyrroles: size and site-specific binding to G-quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A chiral wedge molecule inhibits telomerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA.iron(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A 6-mer photocontrolled oligonucleotide as an effective telomerase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

TERRA: telomeric repeat-containing RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

G-quadruplex formation by human telomeric repeats-containing RNA in Na+ solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomeric repeat-containing RNA structure in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Evidence that exposure of the telomere 3' overhang sequence induces senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

TERRA transcripts are bound by a complex array of RNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Alternative lengthening of telomeres: models, mechanisms and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Chemistry and biology of DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Recombinational telomere elongation promoted by DNA circles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Artificial human telomeres from DNA nanocircle templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

P bodies: at the crossroads of post-transcriptional pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Targeting telomeres and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Shedding Light on the Interaction between TMPyP4 and Human Telomeric Quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

FRET Templated by G-Quadruplex DNA: A Specific Ternary Interaction Using an Original Pair of Donor/Acceptor Partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

Stabilization and Structure of Telomeric and c-myc Region Intramolecular G-Quadruplexes: The Role of Central Cations and Small Planar Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CS00134A

21 January 2018

Identifiers

DOI

10.1039/C0CS00134A

1 reference

29 July 2017

1 reference