Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. (Q34330929)

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English	Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease.	scientific article

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25 February 2020

Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease (English)

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Europe PubMed Central

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25 February 2020

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Alzheimer's disease

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1

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25 February 2020

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D W Shineman

2

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25 February 2020

H M Fillit

3

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1 March 2013

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25 February 2020

The Journal of Nutrition, Health and Aging

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25 February 2020

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25 February 2020

3

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25 February 2020

240-251

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25 February 2020

Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood

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Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study

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Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature

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Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe

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EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials

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Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression

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Omega-3 polyunsaturated fatty acids in Alzheimer's disease: key questions and partial answers.

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Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults

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DHA status of vegetarians

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Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation

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Dietary sources of omega 3 fatty acids: public health risks and benefits

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Sources of the very-long-chain unsaturated omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid

1 reference

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The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish

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Frequency and type of seafood consumed influence plasma (n-3) fatty acid concentrations

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Long chain omega-3 dietary supplements: a review of the National Library of Medicine Herbal Supplement Database

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Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial).

1 reference

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Novel developments in omega-3 fatty acid-based strategies

1 reference

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21 January 2018

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

1 reference

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21 January 2018

Clinical overview of algal-docosahexaenoic acid: effects on triglyceride levels and other cardiovascular risk factors

1 reference

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21 January 2018

Algal-oil capsules and cooked salmon: nutritionally equivalent sources of docosahexaenoic acid

1 reference

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21 January 2018

Microalgal biofactories: a promising approach towards sustainable omega-3 fatty acid production

1 reference

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Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study

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21 January 2018

Health effects of dietary phospholipids

1 reference

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21 January 2018

Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension

1 reference

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21 January 2018

Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil.

1 reference

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21 January 2018

Omega-3 fatty acids and dementia.

1 reference

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21 January 2018

An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids.

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21 January 2018

Innovative dietary sources of n-3 fatty acids

1 reference

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21 January 2018

Challenges for the delivery of long-chain n-3 fatty acids in functional foods

1 reference

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21 January 2018

The cognitive neuroscience of ageing

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21 January 2018

Fish, docosahexaenoic acid and Alzheimer's disease

1 reference

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21 January 2018

The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy ol

1 reference

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21 January 2018

Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging.

1 reference

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21 January 2018

Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging.

1 reference

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21 January 2018

Intakes of (n-3) fatty acids and fatty fish are not associated with cognitive performance and 6-year cognitive change in men participating in the Veterans Affairs Normative Aging Study

1 reference

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21 January 2018

Effects of ω-3 fatty acids on cognitive performance: a meta-analysis

1 reference

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21 January 2018

Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial

1 reference

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21 January 2018

Serum fatty-acid composition and the risk of Alzheimer's disease: a longitudinal population-based study.

1 reference

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21 January 2018

Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.

1 reference

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21 January 2018

Omega 3 fatty acids and cognitive health in older people

1 reference

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21 January 2018

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

1 reference

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21 January 2018

Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study

1 reference

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21 January 2018

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms.

1 reference

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21 January 2018

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial

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21 January 2018

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study

1 reference

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21 January 2018

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

1 reference

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21 January 2018

Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial

1 reference

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The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

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21 January 2018

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

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21 January 2018

Vascular and metabolic dysfunction in Alzheimer's disease: a review

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21 January 2018

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association

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Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials

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21 January 2018

Do long-chain n-3 fatty acids reduce arterial stiffness? A meta-analysis of randomised controlled trials.

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21 January 2018

Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review.

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21 January 2018

Omega 3 polyunsaturated fatty acids and body weight

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Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis.

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21 January 2018

Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective

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21 January 2018

Fatty acids and inflammation: the cutting edge between food and pharma.

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21 January 2018

Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease

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21 January 2018

Effect of fish oil supplementation on quality of life in a general population of older Dutch subjects: a randomized, double-blind, placebo-controlled trial.

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21 January 2018

Essential fatty acids preparation (SR-3) improves Alzheimer's patients quality of life.

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21 January 2018

Toxicology and safety of DHA.

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21 January 2018

A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease

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21 January 2018

Dietary n-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects.

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21 January 2018

Enrichment of foods with omega-3 fatty acids: a multidisciplinary challenge

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21 January 2018

What was lost in translation in the DHA trial is whom you should intend to treat

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21 January 2018

Dietary fatty acids and the aging brain

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21 January 2018

Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice

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21 January 2018

Omega-3 fatty acids: potential role in the management of early Alzheimer's disease

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21 January 2018

Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.

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21 January 2018

Dietary fat intake--a global perspective

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21 January 2018

Effects of n-3 fatty acids on cognitive decline: a randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients

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21 January 2018

Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial

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21 January 2018

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype

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21 January 2018

Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil.

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21 January 2018

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.

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21 January 2018

Supplementation with B vitamins or n-3 fatty acids and depressive symptoms in cardiovascular disease survivors: ancillary findings from the SUpplementation with FOLate, vitamins B-6 and B-12 and/or OMega-3 fatty acids (SU.FOL.OM3) randomized trial

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21 January 2018

Cross-sectional but not longitudinal association between n-3 fatty acid intake and depressive symptoms: results from the SU.VI.MAX 2 study

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21 January 2018

Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison

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21 January 2018

The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results?

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21 January 2018

Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.

1 reference

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21 January 2018

The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases

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21 January 2018

n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials

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21 January 2018

Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory From the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on E

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21 January 2018

Bioavailability of marine n-3 fatty acid formulations

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21 January 2018

Enhanced increase of omega-3 index in response to long-term n-3 fatty acid supplementation from triacylglycerides versus ethyl esters

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21 January 2018

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study.

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21 January 2018

Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study

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21 January 2018

Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography

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21 January 2018

Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission

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21 January 2018

Biomarkers of DHA status

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21 January 2018

Dietary methods and biomarkers of omega 3 fatty acids: a systematic review

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21 January 2018

Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly

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21 January 2018

Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat.

1 reference

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21 January 2018

Omega-3 fatty acids and neurological injury

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21 January 2018

IAGG workshop: health promotion program on prevention of late onset dementia.

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21 January 2018

The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease

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21 January 2018

The human plasma lipidome

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21 January 2018

Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials

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21 January 2018

Effects of long-chain polyunsaturated fatty acid supplementation on neurodevelopment in childhood: a review of human studies

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21 January 2018

Omega-3 fatty acids. What consumers need to know

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21 January 2018

Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence?

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Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

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Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association

1 reference

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12 December 2020

based on heuristic

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Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management

1 reference

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Fatty Acid Profile of Erythrocyte Membranes As Possible Biomarker of Longevity

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12 December 2020

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Effects of dietary stearidonic acid on biomarkers of lipid metabolism

1 reference

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12 December 2020

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Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial

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https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

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Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis

1 reference

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12 December 2020

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Metabolism and longevity: is there a role for membrane fatty acids?

1 reference

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12 December 2020

based on heuristic

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Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo

1 reference

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12 December 2020

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Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids.

1 reference

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12 December 2020

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Fatty acids from lipids of marine organisms: molecular biodiversity, roles as biomarkers, biologically active compounds, and economical aspects

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Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006

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Omega-3 fatty acids and risk of cognitive impairment and dementia

1 reference

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NIH state-of-the-science conference statement: Preventing Alzheimer's disease and cognitive decline

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based on heuristic

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Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Distribution, interconversion, and dose response of n-3 fatty acids in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n−3 fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Omega 3 fatty acid for the prevention of cognitive decline and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are drugmakers fishing for a market with prescription omega-3s?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23459977

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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