Notch signaling in pediatric soft tissue sarcomas (Q34480012)

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Notch signaling in pediatric soft tissue sarcomas (English)

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18 February 2020

Lucio Miele

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3

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18 February 2020

author name string

Roberta Ciarapica

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2

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18 February 2020

Franco Locatelli

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16 November 2012

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3 April 2019

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https://scigraph.springernature.com/pub.10.1186/1741-7015-10-141

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cites work

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A TARBP2-dependent miRNA expression profile underlies cancer stem cell properties and provides candidate therapeutic reagents in Ewing sarcoma

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Targeting the Notch pathway: twists and turns on the road to rational therapeutics

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Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors

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Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy.

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Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.

6 July 2018

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Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways

6 July 2018

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Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.

6 July 2018

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Notch signalling in cancer progression and bone metastasis

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Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

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Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

6 July 2018

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Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis

6 July 2018

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Pediatric ependymomas: will molecular biology change patient management?

6 July 2018

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Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

6 July 2018

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Notch signaling: simplicity in design, versatility in function

6 July 2018

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Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study

6 July 2018

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Notch in T-ALL: new players in a complex disease.

6 July 2018

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Advances in sarcoma genomics and new therapeutic targets

6 July 2018

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Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

6 July 2018

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CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres

6 July 2018

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A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development

6 July 2018

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Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

6 July 2018

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Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

6 July 2018

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Numb regulates Notch1, but not Notch3, during myogenesis.

6 July 2018

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Functional antagonism between histone H3K4 demethylases in vivo

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Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro

6 July 2018

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

6 July 2018

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6 July 2018

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EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor

6 July 2018

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6 July 2018

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Regulation of skeletal myogenesis by Notch

6 July 2018

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Therapeutic antibody targeting of individual Notch receptors

6 July 2018

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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

6 July 2018

1 reference

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Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group

6 July 2018

1 reference

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Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

6 July 2018

1 reference

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

6 July 2018

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Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.

6 July 2018

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The Notch effector Hey1 associates with myogenic target genes to repress myogenesis.

6 July 2018

1 reference

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Direct inhibition of the NOTCH transcription factor complex

6 July 2018

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Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

6 July 2018

1 reference

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Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

6 July 2018

1 reference

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The canonical Notch signaling pathway: unfolding the activation mechanism

6 July 2018

1 reference

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The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

6 July 2018

1 reference

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Notch tumor suppressor function

6 July 2018

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EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma

6 July 2018

1 reference

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Inhibition of myogenesis by Notch: evidence for multiple pathways

6 July 2018

1 reference

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Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

6 July 2018

1 reference

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Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches

6 July 2018

1 reference

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Synovial sarcoma: from genetics to genetic-based animal modeling

6 July 2018

1 reference

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Pediatric soft tissue sarcomas

6 July 2018

1 reference

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Mesenchymal stem cell features of Ewing tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Opposing LSD1 complexes function in developmental gene activation and repression programmes

6 July 2018

1 reference

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Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

6 July 2018

1 reference

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Notch2 negatively regulates myofibroblastic differentiation of myoblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Gene expression profiling of human sarcomas: insights into sarcoma biology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

The spectrum of mutations for CADASIL diagnosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets

6 July 2018

1 reference

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

6 July 2018

1 reference

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Classification and subtype prediction of adult soft tissue sarcoma by functional genomics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

HES and HERP families: multiple effectors of the Notch signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies.

6 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Alzheimer's failure raises questions about disease-modifying strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-10-141

Synovial sarcoma is a stem cell malignancy.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3520771

Notch and PI3K: how is the road traveled?

27 October 2018

1 reference

12 December 2020

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors

1 reference

12 December 2020

Notch-mediated restoration of regenerative potential to aged muscle

1 reference

12 December 2020

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

12 December 2020

The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex

1 reference

12 December 2020

Identifiers

DOI

10.1186/1741-7015-10-141

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23158439%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23158439%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23158439%20AND%20SRC:MED&resulttype=core&format=json