Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview. (Q34976260)

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26 January 2020

review article

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title

Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview (English)

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26 January 2020

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1

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26 January 2020

Helena Carmo

2

1 reference

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26 January 2020

Fernando Remião

3

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26 January 2020

Maria de Lourdes Bastos

4

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26 January 2020

Andreas Meisel

5

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26 January 2020

Félix Carvalho

6

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26 January 2020

author name string

João Paulo Capela

1

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5 August 2017

Helena Carmo

2

1 reference

5 August 2017

Fernando Remião

3

1 reference

5 August 2017

Maria Lourdes Bastos

4

1 reference

5 August 2017

Andreas Meisel

5

1 reference

5 August 2017

Félix Carvalho

6

1 reference

5 August 2017

17 April 2009

1 reference

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26 January 2020

published in

Molecular Neurobiology

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26 January 2020

volume

39

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26 January 2020

issue

3

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26 January 2020

page(s)

210-271

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https://scigraph.springernature.com/pub.10.1007/s12035-009-8064-1

26 January 2020

exact match

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Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants

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Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain

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CYP2D6 deficiency, a factor in ecstasy related deaths?

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The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy').

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2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

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An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine

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Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis.

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Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats

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Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics.

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Memory impairment suggests hippocampal dysfunction in abstinent ecstasy users

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The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers

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Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat

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MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature

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Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

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3,4-Methylenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys

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Molecular mechanism of the inactivation of tryptophan hydroxylase by nitric oxide: attack on critical sulfhydryls that spare the enzyme iron center.

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3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice.

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Differential response of nNOS knockout mice to MDMA ("ecstasy")- and methamphetamine-induced psychomotor sensitization and neurotoxicity

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Cognition in novice ecstasy users with minimal exposure to other drugs: a prospective cohort study

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Information on "Ecstasy"

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Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.

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MDMA ("Ecstasy") abuse and high-risk sexual behaviors among 169 gay and bisexual men

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3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity

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12 December 2020

Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity

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3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans

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Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection.

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Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine.

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Amphetamines induce ubiquitin-positive inclusions within striatal cells.

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Bacterial plate assays and electrochemical methods: an efficient tandem for evaluating the ability of catechol-thioether metabolites of MDMA ("ecstasy") to induce toxic effects through redox-cycling

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12 December 2020

Pharmacogenetics of the serotonin transporter

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12 December 2020

3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.

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12 December 2020

Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse

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12 December 2020

Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin.

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12 December 2020

Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity

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12 December 2020

Psychedelic drugs: the ups and downs of ecstasy

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12 December 2020

Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose.

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12 December 2020

Methylenedioxymethamphetamine (MDMA; Ecstasy) suppresses IL-1beta and TNF-alpha secretion following an in vivo lipopolysaccharide challenge

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12 December 2020

Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPgammaS binding in adult rats

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12 December 2020

Acute medical problems due to Ecstasy use. Case-series of emergency department visits.

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12 December 2020

MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.

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12 December 2020

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct

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12 December 2020

Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations

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12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

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12 December 2020

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences

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12 December 2020

MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.

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12 December 2020

Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity

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12 December 2020

Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of Ecstasy

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12 December 2020

Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users

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12 December 2020

Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.

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12 December 2020

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

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12 December 2020

Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil

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12 December 2020

Amphetamines induce apoptosis and regulation of bcl-x splice variants in neocortical neurons

1 reference

12 December 2020

Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine.

1 reference

12 December 2020

Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists.

1 reference

12 December 2020

Mood, cognition and serotonin transporter availability in current and former ecstasy (MDMA) users: the longitudinal perspective

1 reference

12 December 2020

Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs

1 reference

12 December 2020

Release of serotonin induced by 3,4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further evidence for calcium-independent mechanisms of release

1 reference

12 December 2020

The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes.

1 reference

12 December 2020

Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor

1 reference

12 December 2020

Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats

1 reference

12 December 2020

Role of alpha1-adrenoceptor subtypes in the effects of methylenedioxy methamphetamine (MDMA) on body temperature in the mouse

1 reference

12 December 2020

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

12 December 2020

Hydroxyl radical-mediated oxidation of serotonin: potential insights into the neurotoxicity of methamphetamine

1 reference

12 December 2020

MDMA toxicity presenting with severe hyperpyrexia: a case report

1 reference

12 December 2020

Methylenedioxymethamphetamine-induced inhibition of neuronal firing in the nucleus accumbens is mediated by both serotonin and dopamine.

1 reference

12 December 2020

Effects of ritanserin on the 3,4-methylenedioxymethamphetamine-induced decrease in striatal serotonin concentration and on the increase in striatal neurotensin and dynorphin A concentrations.

1 reference

12 December 2020

Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury

1 reference

12 December 2020

The neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine on serotonin, dopamine, and GABA-ergic terminals: an in-vitro autoradiographic study in rats

1 reference

12 December 2020

Decreased social behaviour following 3,4-methylenedioxymethamphetamine (MDMA) is accompanied by changes in 5-HT2A receptor responsivity

1 reference

12 December 2020

Interactions of amphetamine analogs with human liver CYP2D6

1 reference

12 December 2020

Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals.

1 reference

12 December 2020

The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents

1 reference

12 December 2020

Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.

1 reference

12 December 2020

Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.

1 reference

12 December 2020

Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures

1 reference

12 December 2020

Striatal postsynaptic ultrastructural alterations following methylenedioxymethamphetamine administration

1 reference

12 December 2020

The effect of polymorphism at the serotonin transporter gene on decision-making, memory and executive function in ecstasy users and controls

1 reference

12 December 2020

Pharmacogenetics of catechol-O-methyltransferase: Frequency of low activity allele in a Ghanaian population

1 reference

12 December 2020

The anxiogenic-like and anxiolytic-like effects of MDMA on mice in the elevated plus-maze: a comparison with amphetamine

1 reference

12 December 2020

A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse

1 reference

12 December 2020

Damage of serotonergic axons and immunolocalization of Hsp27, Hsp72, and Hsp90 molecular chaperones after a single dose of MDMA administration in Dark Agouti rat: temporal, spatial, and cellular patterns.

1 reference

12 December 2020

Survival following 'Ecstasy' ingestion with a peak temperature of 42 degrees C.

1 reference

12 December 2020

Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA

1 reference

12 December 2020

Effect of flunarizine and nimodipine on the decrease in tryptophan hydroxylase activity induced by methamphetamine and 3,4-methylenedioxymethamphetamine.

1 reference

12 December 2020

Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome.

1 reference

12 December 2020

Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex

1 reference

12 December 2020

Serotonergic recovery after (+/-)3,4-(methylenedioxy) methamphetamine injury: observations in rats.

1 reference

12 December 2020

‘Ecstasy’ Psychosis and Flashbacks

1 reference

12 December 2020

Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity

1 reference

12 December 2020

Effects of intracerebroventricular administration of 5-(glutathion-S-yl)-alpha-methyldopamine on brain dopamine, serotonin, and norepinephrine concentrations in male Sprague-Dawley rats.

1 reference

12 December 2020

Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques

1 reference

12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

1 reference

12 December 2020

Synthesis and analysis of aminochromes by HPLC-photodiode array. Adrenochrome evaluation in rat blood.

1 reference

12 December 2020

Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement

1 reference

12 December 2020

Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.

1 reference

12 December 2020

Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in animals trained to discriminate hallucinogens from saline.

1 reference

12 December 2020

Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport

1 reference

12 December 2020

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

1 reference

12 December 2020

Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

1 reference

12 December 2020

Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.

1 reference

12 December 2020

Deamination of 5-hydroxytryptamine by both forms of monoamine oxidase in the rat brain.

1 reference

12 December 2020

L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions.

1 reference

12 December 2020

Stereoselective disposition: enantioselective quantitation of 3,4-(methylenedioxy) methamphetamine and three of its metabolites by gas chromatography/electron capture negative ion chemical ionization mass spectrometry

1 reference

12 December 2020

Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine.

1 reference

12 December 2020

Functional consequences of perinatal exposure to 3,4-methylenedioxymethamphetamine in rat brain

1 reference

12 December 2020

Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.

1 reference

12 December 2020

Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines

1 reference

12 December 2020

MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers.

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1 reference

12 December 2020

Long-term effects of "ecstasy" use on serotonin transporters of the brain investigated by PET.

1 reference

12 December 2020

Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects

1 reference

12 December 2020

A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice

1 reference

12 December 2020

Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo

1 reference

12 December 2020

5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures

1 reference

12 December 2020

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.

1 reference

12 December 2020

The effects of MDMA pretreatment on the behavioural effects of other drugs of abuse in the rat elevated plus-maze test

1 reference

12 December 2020

Acute and subchronic effects of MDMA ("ecstasy") on anxiety in male mice tested in the elevated plus-maze.

1 reference

12 December 2020

Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

1 reference

12 December 2020

Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses.

1 reference

12 December 2020

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

1 reference

12 December 2020

Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans.

1 reference

12 December 2020

Memory disturbances in "Ecstasy" users are correlated with an altered brain serotonin neurotransmission.

1 reference

12 December 2020

Elucidation of the genetic basis of the common 'intermediate metabolizer' phenotype for drug oxidation by CYP2D6

1 reference

12 December 2020

Diminished corticotropin and enhanced prolactin responses to 8-hydroxy-2(di-n-propylamino)tetralin in methylenedioxymethamphetamine pretreated rats

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion

1 reference

12 December 2020

Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells.

1 reference

12 December 2020

MDMA administration to pregnant Sprague-Dawley rats results in its passage to the fetal compartment

1 reference

12 December 2020

Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion.

1 reference

12 December 2020

Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): a stressor on the immune system

1 reference

12 December 2020

An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA

1 reference

12 December 2020

DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy).

1 reference

12 December 2020

MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females

1 reference

12 December 2020

Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk

1 reference

12 December 2020

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1 reference

12 December 2020

Investigation of the prejunctional alpha2-adrenoceptor mediated actions of MDMA in rat atrium and vas deferens

1 reference

12 December 2020

Functional MRI study of working memory in MDMA users

1 reference

12 December 2020

Methylenedioxymethamphetamine (MDMA, ‘Ecstasy‘) Serves as a Robust Positive Reinforcer in a Rat Runway Procedure

1 reference

12 December 2020

Ecstasy (MDMA): are the psychological problems associated with its use reversed by prolonged abstinence?

1 reference

12 December 2020

Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.

1 reference

12 December 2020

Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats

1 reference

12 December 2020

Cardiovascular and sympathetic responses and reflex changes elicited by MDMA.

1 reference

12 December 2020

Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity.

1 reference

12 December 2020

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

1 reference

12 December 2020

Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine).

1 reference

12 December 2020

1 reference

12 December 2020

Detection of free radical activity during transient global ischemia and recirculation: effects of intraischemic brain temperature modulation

1 reference

12 December 2020

Ecstasy (3,4-methylenedioxymethamphetamine) limits murine gammaherpesvirus-68 induced monokine expression

1 reference

12 December 2020

Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms.

1 reference

12 December 2020

Pharmacogenetics of sulfotransferase

1 reference

12 December 2020

The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones

1 reference

12 December 2020

V79 Chinese hamster cells genetically engineered for polymorphic cytochrome P450 2D6 and their predictive value for humans

1 reference

12 December 2020

Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice

1 reference

12 December 2020

Tryptamine-4,5-dione, a putative endotoxic metabolite of the superoxide-mediated oxidation of serotonin, is a mitochondrial toxin: possible implications in neurodegenerative brain disorders.

1 reference

12 December 2020

MDMA induces caspase-3 activation in the limbic system but not in striatum

1 reference

12 December 2020

Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity

1 reference

12 December 2020

Caffeine promotes hyperthermia and serotonergic loss following co-administration of the substituted amphetamines, MDMA ("Ecstasy") and MDA ("Love").

1 reference

12 December 2020

Immunochemical detection of quinol--thioether-derived protein adducts

1 reference

12 December 2020

Role of brain nitric oxide in (+/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.

1 reference

12 December 2020

Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces selective serotonergic depletion in the nonhuman primate.

1 reference

12 December 2020

Neurotransmitter systems of the medial prefrontal cortex: potential role in sensitization to psychostimulants

1 reference

12 December 2020

5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

1 reference

12 December 2020

The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): an evidence-based review

1 reference

12 December 2020

Biochemical and toxicological properties of the oxidation products of catecholamines

1 reference

12 December 2020

Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats

1 reference

12 December 2020

Cognitive performance amongst recreational users of "ecstasy".

1 reference

12 December 2020

Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene.

1 reference

12 December 2020

Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") and its reversal by clozapine

1 reference

12 December 2020

Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

1 reference

12 December 2020

Assessment of the MDA and MDMA optical isomers in a stimulant-hallucinogen discrimination.

1 reference

12 December 2020

The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain

1 reference

12 December 2020

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

1 reference

12 December 2020

Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.

1 reference

12 December 2020

Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain

1 reference

12 December 2020

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse

1 reference

12 December 2020

Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

1 reference

12 December 2020

A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives

1 reference

12 December 2020

A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats.

1 reference

12 December 2020

Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX

1 reference

12 December 2020

Neuropsychiatric manifestations following the use of 3,4-methylenedioxymethamphetamine (MDMA: "Ecstasy").

1 reference

12 December 2020

Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity

1 reference

12 December 2020

Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord.

1 reference

12 December 2020

Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation

1 reference

12 December 2020

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene

1 reference

12 December 2020

Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites

1 reference

12 December 2020

On the role of tyrosine and peripheral metabolism in 3,4-methylenedioxymethamphetamine-induced serotonin neurotoxicity in rats.

1 reference

12 December 2020

Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR.

1 reference

12 December 2020

A comparison of the reinforcing efficacy of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with cocaine in rhesus monkeys

1 reference

12 December 2020

Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics.

1 reference

12 December 2020

Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins.

1 reference

12 December 2020

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity.

1 reference

12 December 2020

Stereospecific analysis and enantiomeric disposition of 3, 4-methylenedioxymethamphetamine (Ecstasy) in humans

1 reference

12 December 2020

(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane

1 reference

12 December 2020

CB1 cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement

1 reference

12 December 2020

The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers.

1 reference

12 December 2020

Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy').

1 reference

12 December 2020

Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasoconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats.

1 reference

12 December 2020

Major metabolites of(±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons

1 reference

12 December 2020

Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

1 reference

12 December 2020

How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy?

1 reference

12 December 2020

Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2.

1 reference

12 December 2020

Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure

1 reference

12 December 2020

Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period

1 reference

12 December 2020

Neonatal 3,4-methylenedioxymethamphetamine (ecstasy) alters dopamine and serotonin neurochemistry and increases brain-derived neurotrophic factor in the forebrain and brainstem of the rat.

1 reference

12 December 2020

Elevated impulsivity and impaired decision-making in abstinent Ecstasy (MDMA) users compared to polydrug and drug-naïve controls.

1 reference

12 December 2020

Plasma drug concentrations and physiological measures in 'dance party' participants

1 reference

12 December 2020

Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model

1 reference

12 December 2020

MDMA toxicity: no evidence for a major influence of metabolic genotype at CYP2D6.

1 reference

12 December 2020

Impact of psychostimulants on vesicular monoamine transporter function

1 reference

12 December 2020

Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia

1 reference

12 December 2020

Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat

1 reference

12 December 2020

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum

1 reference

12 December 2020

Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys

1 reference

12 December 2020

No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study

1 reference

12 December 2020

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

1 reference

12 December 2020

Immunohistochemical localization and quantification of glial fibrillary acidic protein and synaptosomal-associated protein (mol. wt 25000) in the ageing hippocampus following administration of 5,7-dihydroxytryptamine

1 reference

12 December 2020

Binge administration of 3,4-methylenedioxymethamphetamine ("ecstasy") impairs the survival of neural precursors in adult rat dentate gyrus.

1 reference

12 December 2020

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

1 reference

12 December 2020

3,4-methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development.

1 reference

12 December 2020

Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys

1 reference

12 December 2020

1 reference

12 December 2020

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

1 reference

12 December 2020

Mapping toxicant-induced nervous system damage with a cupric silver stain: a quantitative analysis of neural degeneration induced by 3,4-methylenedioxymethamphetamine.

1 reference

12 December 2020

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

1 reference

12 December 2020

Activation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA) occurs through the stimulation of serotonin receptors and transporter.

1 reference

12 December 2020

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.

1 reference

12 December 2020

Cognitive performance in (+/-) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study

1 reference

12 December 2020

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity

1 reference

12 December 2020

Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance

1 reference

12 December 2020

Further insights into the influence of L-cysteine on the oxidation chemistry of dopamine: reaction pathways of potential relevance to Parkinson's disease

1 reference

12 December 2020

Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies

1 reference

12 December 2020

Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference

1 reference

12 December 2020

MDMA modifies active avoidance learning and recall in mice

1 reference

12 December 2020

Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA)

1 reference

12 December 2020

A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain

1 reference

12 December 2020

Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices

1 reference

12 December 2020

Altered states: the clinical effects of Ecstasy.

1 reference

12 December 2020

The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans.

1 reference

12 December 2020

Impulsivity, risk taking and recreational 'ecstasy' (MDMA) use.

1 reference

12 December 2020

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)

1 reference

12 December 2020

Pharmacology: uncoupling the agony from ecstasy

1 reference

12 December 2020

Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning

1 reference

12 December 2020

Neuroendocrine responses of healthy volunteers to 'techno-music': relationships with personality traits and emotional state

1 reference

12 December 2020

Fatal MDMA intoxication

1 reference

12 December 2020

Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

1 reference

12 December 2020

Influences of the corticotropic axis and sympathetic activity on neurochemical consequences of 3,4-methylenedioxymethamphetamine (MDMA) administration in Fischer 344 rats

1 reference

12 December 2020

Pathology of deaths associated with "ecstasy" and "eve" misuse

1 reference

12 December 2020

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.

1 reference

12 December 2020

Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain

1 reference

12 December 2020

Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat.

1 reference

12 December 2020

Contribution of cannabis and MDMA ("ecstasy") to cognitive changes in long-term polydrug users

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings

1 reference

12 December 2020

Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve alpha-adrenoceptors

1 reference

12 December 2020

Fatal uncertainty: death-rate from use of ecstasy or heroin

1 reference

12 December 2020

Selective 5-hydroxytryptamine2 receptor antagonists protect against the neurotoxicity of methylenedioxymethamphetamine in rats.

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity

1 reference

12 December 2020

Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells

1 reference

12 December 2020

Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat

1 reference

12 December 2020

Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione

1 reference

12 December 2020

Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges

1 reference

12 December 2020

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine

1 reference

12 December 2020

Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin

1 reference

12 December 2020

Repeated MDMA ("Ecstasy") exposure in adolescent male rats alters temperature regulation, spontaneous motor activity, attention, and serotonin transporter binding

1 reference

12 December 2020

Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity

1 reference

12 December 2020

3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein

1 reference

12 December 2020

Does GFAP mRNA and mitochondrial benzodiazepine receptor binding detect serotonergic neuronal degeneration in rat?

1 reference

12 December 2020

Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex.

1 reference

12 December 2020

MDMA (ecstasy) effects on cultured serotonergic neurons: evidence for Ca2(+)-dependent toxicity linked to release.

1 reference

12 December 2020

Ecstasy and the dance of death

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12 December 2020

Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs

1 reference

12 December 2020

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies.

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12 December 2020

Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: importance in pathophysiology and pathogenesis

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12 December 2020

Neurotoxicity mechanisms of thioether ecstasy metabolites.

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12 December 2020

Monoamine Oxidase-B Mediates Ecstasy-Induced Neurotoxic Effects to Adolescent Rat Brain Mitochondria

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12 December 2020

Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons

1 reference

12 December 2020

Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction.

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12 December 2020

Sympathomimetic actions of methylenedioxymethamphetamine in rat and rabbit isolated cardiovascular tissues

1 reference

12 December 2020

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse

1 reference

12 December 2020

Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice

1 reference

12 December 2020

A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation

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12 December 2020

The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity

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12 December 2020

Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat.

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12 December 2020

A voxel-based PET investigation of the long-term effects of "Ecstasy" consumption on brain serotonin transporters.

1 reference

12 December 2020

Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice

1 reference

12 December 2020

Amphetamine induces dopamine efflux through a dopamine transporter channel.

1 reference

12 December 2020

The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats

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12 December 2020

Memantine prevents MDMA-induced neurotoxicity

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12 December 2020

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1 reference

12 December 2020

Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes

1 reference

12 December 2020

Effects of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine isomers on central serotonergic, dopaminergic and nigral neurotensin systems of the rat.

1 reference

12 December 2020

Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum.

1 reference

12 December 2020

The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6)

1 reference

12 December 2020

Serotonergic neurotoxicity of MDMA (ecstasy) in the developing rat brain.

1 reference

12 December 2020

Cytochromes P450 and metabolism of xenobiotics

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12 December 2020

Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro

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12 December 2020

The role of temperature, stress, and other factors in the neurotoxicity of the substituted amphetamines 3,4-methylenedioxymethamphetamine and fenfluramine

1 reference

12 December 2020

Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra.

1 reference

12 December 2020

Low-dose MDMA ("ecstasy") induces vasopressin secretion.

1 reference

12 December 2020

Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats

1 reference

12 December 2020

The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in rats

1 reference

12 December 2020

Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines

1 reference

12 December 2020

Pharmacogenetics of the major polymorphic metabolizing enzymes.

1 reference

12 December 2020

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

1 reference

12 December 2020

Risperidone attenuates and reverses hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats

1 reference

12 December 2020

Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain.

1 reference

12 December 2020

N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia

1 reference

12 December 2020

Ecstasy use and self-reported depression, impulsivity, and sensation seeking: a prospective cohort study

1 reference

12 December 2020

MDMA elicits behavioral and neurochemical sensitization in rats.

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine ('Ecstasy') promotes the translocation of protein kinase C (PKC): requirement of viable serotonin nerve terminals

1 reference

12 December 2020

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes

1 reference

12 December 2020

Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions.

1 reference

12 December 2020

In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain

1 reference

12 December 2020

Phospholipase A2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability

1 reference

12 December 2020

Incidental use of ecstasy: no evidence for harmful effects on cognitive brain function in a prospective fMRI study.

1 reference

12 December 2020

The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity.

1 reference

12 December 2020

Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms

1 reference

12 December 2020

Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature

1 reference

12 December 2020

Interaction of amphetamines and related compounds at the vesicular monoamine transporter

1 reference

12 December 2020

Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats

1 reference

12 December 2020

Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan

1 reference

12 December 2020

Induction of Malignant Hyperthermia in Susceptible Swine by 3,4-Methylenedioxymethamphetamine (“Ecstasy”)

1 reference

12 December 2020

Long term psychiatric and cognitive effects of MDMA use.

1 reference

12 December 2020

Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations

1 reference

12 December 2020

Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine.

1 reference

12 December 2020

Some behavioural and neurochemical aspects of subacute (+/-)3,4-methylenedioxymethamphetamine administration in rats

1 reference

12 December 2020

A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine

1 reference

12 December 2020

In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism.

1 reference

12 December 2020

N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy').

1 reference

12 December 2020

Ecstasy: are animal data consistent between species and can they translate to humans?

1 reference

12 December 2020

Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans

1 reference

12 December 2020

Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites

1 reference

12 December 2020

Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes

1 reference

12 December 2020

Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry.

1 reference

12 December 2020

Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not by fenfluramine.

1 reference

12 December 2020

Pharmacogenomics--drug disposition, drug targets, and side effects

1 reference

12 December 2020

Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ("ecstasy") polydrug users

1 reference

12 December 2020

Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat.

1 reference

12 December 2020

The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine

1 reference

12 December 2020

Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols

1 reference

12 December 2020

The acute and chronic effects of MDMA ("ecstasy") on cortical 5-HT2A receptors in rat and human brain

1 reference

12 December 2020

2-Deoxy-D-glucose prevents and nicotinamide potentiates 3, 4-methylenedioxymethamphetamine-induced serotonin neurotoxicity.

1 reference

12 December 2020

Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats.

1 reference

12 December 2020

(+/-)3,4-Methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates

1 reference

12 December 2020

In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine

1 reference

12 December 2020

Phosphorylation and regulation of antidepressant-sensitive serotonin transporters

1 reference

12 December 2020

10.1007/S12035-009-8064-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19373443%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 January 2020

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