AID to overcome the limitations of genomic information (Q36170796)

12 August 2017

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title

AID to overcome the limitations of genomic information (English)

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12 August 2017

1

Tasuku Honjo

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12 August 2017

4

Masamichi Muramatsu

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12 August 2017

Hitoshi Nagaoka

2

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PubMed ID

15970938

12 August 2017

Reiko Shinkura

series ordinal

3

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PubMed ID

15970938

12 August 2017

language of work or name

English

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publication date

1 July 2005

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12 August 2017

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12 August 2017

6

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12 August 2017

7

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12 August 2017

655-661

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V(D)J recombination: RAG proteins, repair factors, and regulation

12 August 2017

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21 January 2018

Somatic hypermutation

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

21 January 2018

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Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

21 January 2018

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

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Circular DNA is excised by immunoglobulin class switch recombination

21 January 2018

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Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching

21 January 2018

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Circular DNA is a product of the immunoglobulin class switch rearrangement

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

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Activation-induced deaminase: controversies and open questions

21 January 2018

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The regulation of somatic hypermutation

21 January 2018

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

21 January 2018

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Transcription-coupled mutagenesis by the DNA deaminase AID

21 January 2018

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The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies

21 January 2018

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Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

21 January 2018

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DNA deamination in immunity

21 January 2018

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

21 January 2018

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Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

21 January 2018

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De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

21 January 2018

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DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase

21 January 2018

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

21 January 2018

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Separate domains of AID are required for somatic hypermutation and class-switch recombination

21 January 2018

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AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

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Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

21 January 2018

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By-products of immunoglobulin somatic hypermutation

21 January 2018

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De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

21 January 2018

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Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

21 January 2018

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Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

21 January 2018

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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

21 January 2018

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An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22

21 January 2018

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The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

21 January 2018

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Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

21 January 2018

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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

21 January 2018

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Expression of the AID protein in normal and neoplastic B cells

21 January 2018

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

21 January 2018

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Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

21 January 2018

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Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

21 January 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

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Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

21 January 2018

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

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DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

21 January 2018

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Recombinogenic phenotype of human activation-induced cytosine deaminase.

21 January 2018

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In Vitro Deamination of Cytosine to Uracil in Single-stranded DNA by Apolipoprotein B Editing Complex Catalytic Subunit 1 (APOBEC1)

21 January 2018

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

21 January 2018

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

21 January 2018

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DNA-dependent protein kinase activity is not required for immunoglobulin class switching

21 January 2018

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Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

21 January 2018

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Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

21 January 2018

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Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

21 January 2018

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MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes

21 January 2018

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Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

21 January 2018

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DNA double strand breaks occur independent of AID in hypermutating Ig genes

21 January 2018

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The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

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Transcription-coupled events associating with immunoglobulin switch region chromatin

21 January 2018

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The double-edged sword of activation-induced cytidine deaminase.

21 January 2018

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21 January 2018

Marginal-zone B cells

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Somatic hypermutation of the AID transgene in B and non-B cells

21 January 2018

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Constitutive expression of AID leads to tumorigenesis

21 January 2018

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

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A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

21 January 2018

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Mismatch repair and immunoglobulin gene hypermutation: did we learn something?

21 January 2018

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

21 January 2018

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Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation

21 January 2018

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What role for AID: mutator, or assembler of the immunoglobulin mutasome?

21 January 2018

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Genome-wide somatic hypermutation

21 January 2018

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Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

21 January 2018

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Regulation of E2A activities by histone acetyltransferases in B lymphocyte development

21 January 2018

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RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination

21 January 2018

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Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope

21 January 2018

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Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

21 January 2018

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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

21 January 2018

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An evolutionarily conserved target motif for immunoglobulin class-switch recombination

21 January 2018

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Palindromic but not G-rich sequences are targets of class switch recombination

21 January 2018

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Quantitative regulation of class switch recombination by switch region transcription

21 January 2018

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Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

21 January 2018

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EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching

21 January 2018

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Finishing the euchromatic sequence of the human genome

21 January 2018

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7 January 2021

Progress in understanding the mechanism and consequences of somatic hypermutation

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7 January 2021

Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer

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7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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7 January 2021

AID and mismatch repair in antibody diversification

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7 January 2021

The PU.1 and NF-EM5 binding motifs in the Igkappa 3' enhancer are responsible for directing somatic hypermutations to the intrinsic hotspots in the transgenic Vkappa gene

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7 January 2021

Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

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7 January 2021

The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

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7 January 2021

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

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7 January 2021

The influence of transcriptional orientation on endogenous switch region function

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7 January 2021

Identifiers

DOI

10.1038/NI1218

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12 August 2017

1 reference

PubMed ID

15970938