Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo (Q36436702)

14 August 2017

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title

Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo (English)

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14 August 2017

G M Wahl

1

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14 August 2017

1 June 2006

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Cell Death & Differentiation

14 August 2017

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14 August 2017

13

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14 August 2017

6

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14 August 2017

973-983

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401911

14 August 2017

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cites work

Identification of new polypeptide species (48–55K) immunoprecipitable by antiserum to purified large T antigen and present in SV40-infected and -transformed cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

21 January 2018

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T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 mutations in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The MDM2 gene amplification database

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The p53MH algorithm and its application in detecting p53-responsive genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Identification of a novel p53 functional domain that is necessary for mediating apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Refined solution structure of the oligomerization domain of the tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 domains: structure, oligomerization, and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

How p53 binds DNA as a tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Acetylation of p53 inhibits its ubiquitination by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

21 January 2018

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Regulation of p53 activity through lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Allosteric activation of latent p53 tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Activation of the cryptic DNA binding function of mutant forms of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 linear diffusion along DNA requires its C terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Molecular mechanism of the interaction between MDM2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Radiation-induced apoptosis in developing mouse retina exhibits dose-dependent requirement for ATM phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Phosphorylation of serine 18 regulates distinct p53 functions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The C terminus of p53 family proteins is a cell fate determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

p53 must be competent for transcriptional regulation to suppress tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Explaining the biological activity of transactivation-deficient p53 variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdm2 binds p73 alpha without targeting degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

MDM2 suppresses p73 function without promoting p73 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Involvement of the DNA repair protein hHR23 in p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The cellular response to p53: the decision between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdmx and Mdm2: brothers in arms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdmx as an essential regulator of p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A dynamic role of HAUSP in the p53-Mdm2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Dynamics of the p53-Mdm2 feedback loop in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Phosphorylation of HDM2 by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Medical genetics: a marker for Stevens-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Critical contribution of the MDM2 acidic domain to p53 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Critical role for a central part of Mdm2 in the ubiquitylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

The oligomerization domain of p53: Crystal structure of the trigonal form

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

The C-terminus of p53: the more you learn the less you know

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401911

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401911

1 reference

14 August 2017

1 reference

PubMed ID

16575406