N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence (Q36512298)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23248303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence (English)

1 reference

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Kerstin Kampa-Schittenhelm

20 February 2020

author

5

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20 February 2020

Brett C Sheppard

6

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20 February 2020

author name string

Zhiping Wang

1

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20 February 2020

Yuangang Liu

2

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20 February 2020

Maho Takahashi

3

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20 February 2020

Kathryn Van Hook

4

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20 February 2020

Rosalie C Sears

7

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20 February 2020

Philip J S Stork

8

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20 February 2020

Charles D Lopez

9

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20 February 2020

language of work or name

English

0 references

publication date

17 December 2012

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

20 February 2020

published in

1 reference

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20 February 2020

volume

110

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20 February 2020

issue

1

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20 February 2020

page(s)

312-317

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Autophagic activity dictates the cellular response to oncogenic RAS.

20 February 2020

cites work

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PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.

30 September 2017

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ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development

30 September 2017

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30 September 2017

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30 September 2017

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New insights into the expanding complexity of the tumor suppressor ASPP2.

30 September 2017

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Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

30 September 2017

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The structure and interactions of the proline-rich domain of ASPP2

30 September 2017

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Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2.

30 September 2017

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Cellular senescence: when bad things happen to good cells

30 September 2017

1 reference

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Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold

30 September 2017

1 reference

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Hyperactive Ras in developmental disorders and cancer

30 September 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

30 September 2017

1 reference

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ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth

30 September 2017

1 reference

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ASPP [corrected] and cancer

30 September 2017

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Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

30 September 2017

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Control of ASPP2/(53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function

30 September 2017

1 reference

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

30 September 2017

1 reference

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

30 September 2017

1 reference

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Ras-independent activation of ERK signaling via the torso receptor tyrosine kinase is mediated by Rap1.

30 September 2017

1 reference

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The RAF proteins take centre stage

30 September 2017

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The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

30 September 2017

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Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing

30 September 2017

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ASPP1 and ASPP2: common activators of p53 family members

30 September 2017

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

30 September 2017

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Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

30 September 2017

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ASPP proteins specifically stimulate the apoptotic function of p53

30 September 2017

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Active Ras induces heterodimerization of cRaf and BRaf

30 September 2017

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Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

30 September 2017

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Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

30 September 2017

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

30 September 2017

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

30 September 2017

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 September 2017

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

30 September 2017

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Senescence of human fibroblasts induced by oncogenic Raf.

30 September 2017

1 reference

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Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

30 September 2017

1 reference

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Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538245

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

30 September 2017

1 reference

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Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

30 September 2017

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The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

30 September 2017

1 reference

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Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

30 September 2017

1 reference

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Two cellular proteins that bind to wild-type but not mutant p53

30 September 2017

1 reference

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SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

30 September 2017

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Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

28 June 2018

1 reference

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PPP1CA contributes to the senescence program induced by oncogenic Ras.

28 June 2018

1 reference

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 September 2018

1 reference

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Cell polarity: ASPP2 gets a polarity complex

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23248303

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1201514110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23248303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23248303%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

23248303

1 reference