Antigen receptor diversification and chromosome translocations (Q36887122)

16 August 2017

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title

Antigen receptor diversification and chromosome translocations (English)

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16 August 2017

Michel C. Nussenzweig

series ordinal

3

object named as

Michel C Nussenzweig

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16 August 2017

Mila Jankovic

1

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PubMed ID

17641661

16 August 2017

André Nussenzweig

series ordinal

2

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PubMed ID

17641661

16 August 2017

language of work or name

English

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publication date

1 August 2007

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16 August 2017

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16 August 2017

8

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16 August 2017

801-808

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16 August 2017

8

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Structural phylogenetic analysis of activation-induced deaminase function

16 August 2017

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Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions

21 January 2018

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Antibody regulation of B cell development

21 January 2018

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7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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7 January 2021

V(D)J recombination: how to tame a transposase

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7 January 2021

Predominant autoantibody production by early human B cell precursors

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7 January 2021

Receptor editing: an approach by autoreactive B cells to escape tolerance

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7 January 2021

Receptor editing in self-reactive bone marrow B cells

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7 January 2021

Contribution of Receptor Editing to the Antibody Repertoire

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7 January 2021

In vivo imaging of germinal centres reveals a dynamic open structure

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7 January 2021

A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs

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7 January 2021

Antibody class switching mediated by yeast endonuclease-generated DNA breaks.

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7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

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7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

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7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

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7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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7 January 2021

AID from bony fish catalyzes class switch recombination

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7 January 2021

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.

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7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

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7 January 2021

AID to overcome the limitations of genomic information

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7 January 2021

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

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7 January 2021

MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification

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7 January 2021

Common fragile sites as targets for chromosome rearrangements

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7 January 2021

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

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7 January 2021

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

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7 January 2021

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

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7 January 2021

Mechanisms of chromosomal translocations in B cell lymphomas

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7 January 2021

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7 January 2021

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

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7 January 2021

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

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7 January 2021

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

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7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

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7 January 2021

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

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7 January 2021

RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

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7 January 2021

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

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7 January 2021

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

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7 January 2021

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

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7 January 2021

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

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7 January 2021

The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.

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7 January 2021

Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints

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7 January 2021

V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

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7 January 2021

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

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7 January 2021

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

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7 January 2021

RAGs and regulation of autoantibodies

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7 January 2021

Neoplastic development in plasma cells

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7 January 2021

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

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7 January 2021

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

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7 January 2021

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

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7 January 2021

AID is required for c-myc/IgH chromosome translocations in vivo

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7 January 2021

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

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7 January 2021

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

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7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

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7 January 2021

DNA double-strand break repair: all's well that ends well

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7 January 2021

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

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7 January 2021

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

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7 January 2021

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

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7 January 2021

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

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7 January 2021

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

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7 January 2021

Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.

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7 January 2021

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

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7 January 2021

Constitutive expression of AID leads to tumorigenesis

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7 January 2021

Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

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7 January 2021

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

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7 January 2021

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7 January 2021

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

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7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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7 January 2021

The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage

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7 January 2021

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation

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7 January 2021

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

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7 January 2021

H2AX: the histone guardian of the genome

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7 January 2021

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

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7 January 2021

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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7 January 2021

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

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7 January 2021

Sensing of intermediates in V(D)J recombination by ATM.

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7 January 2021

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

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7 January 2021

ATM and ataxia telangiectasia

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7 January 2021

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

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7 January 2021

ATM is required for efficient recombination between immunoglobulin switch regions

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7 January 2021

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

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7 January 2021

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

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7 January 2021

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

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7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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7 January 2021

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

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7 January 2021

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

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7 January 2021

A murine model of Nijmegen breakage syndrome

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7 January 2021

V(D)J rearrangement in Nijmegen breakage syndrome

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7 January 2021

Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

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7 January 2021

Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: an 8-year follow-up study in a single centre.

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7 January 2021

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

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7 January 2021

Nibrin functions in Ig class-switch recombination

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7 January 2021

Genomic instability in mice lacking histone H2AX

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7 January 2021

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

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7 January 2021

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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7 January 2021

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

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7 January 2021

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

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7 January 2021

Switching on chromosomal translocations

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7 January 2021

53BP1, an activator of ATM in response to DNA damage

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7 January 2021

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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7 January 2021

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

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7 January 2021

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

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7 January 2021

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

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7 January 2021

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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7 January 2021

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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7 January 2021

53BP1 is required for class switch recombination

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7 January 2021

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

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7 January 2021

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

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7 January 2021

Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells

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7 January 2021

The cellular response to general and programmed DNA double strand breaks

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7 January 2021

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination

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7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

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7 January 2021

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

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7 January 2021

Ku80 is required for immunoglobulin isotype switching

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7 January 2021

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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7 January 2021

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

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7 January 2021

The role of DNA breaks in genomic instability and tumorigenesis

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7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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7 January 2021

Role of DNA-PK in the cellular response to DNA double-strand breaks

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7 January 2021

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

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7 January 2021

p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc

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7 January 2021

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

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7 January 2021

Deletion of Ku86 causes early onset of senescence in mice

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7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

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7 January 2021

The mechanism and regulation of chromosomal V(D)J recombination

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7 January 2021

How to make ends meet in V(D)J recombination

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7 January 2021

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

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7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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7 January 2021

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

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7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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7 January 2021

Harmonising the response to DSBs: a new string in the ATM bow.

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7 January 2021

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

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7 January 2021

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

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7 January 2021

Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

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7 January 2021

Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

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7 January 2021

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development

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7 January 2021

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

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7 January 2021

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

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7 January 2021

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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7 January 2021

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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7 January 2021

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

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7 January 2021

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

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7 January 2021

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

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7 January 2021

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

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7 January 2021

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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7 January 2021

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells

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7 January 2021

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

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7 January 2021

Identifiers

DOI

10.1038/NI1498

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16 August 2017

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PubMed ID

17641661