Antisense makes sense in engineered regenerative medicine (Q37328072)

19 August 2017

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title

Antisense makes sense in engineered regenerative medicine (English)

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19 August 2017

main subject

regenerative medicine

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Yongchang Yao

1

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Chunming Wang

object named as

Chunming Wang

series ordinal

2

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Dong-An Wang

object named as

Dong-An Wang

series ordinal

4

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Rohan Varshney

series ordinal

3

object named as

Rohan R Varshney

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19 August 2017

publication date

18 November 2008

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19 August 2017

published in

Pharmaceutical Research

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19 August 2017

volume

26

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19 August 2017

issue

2

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19 August 2017

page(s)

263-275

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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

19 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11095-008-9772-3

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-008-9772-3

Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-008-9772-3

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-008-9772-3

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-008-9772-3

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

21 January 2018

1 reference

12 December 2020

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy

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12 December 2020

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

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12 December 2020

Life-or-death decisions by the Bcl-2 protein family.

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12 December 2020

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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12 December 2020

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

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12 December 2020

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

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12 December 2020

Antisense oligodeoxynucleotides prevent acute cardiac allograft rejection via a novel, nontoxic, highly efficient transfection method

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12 December 2020

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

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12 December 2020

MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle.

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12 December 2020

Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemic injury

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12 December 2020

Role of cytokines in rheumatoid arthritis

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12 December 2020

Regulating MHC expression for cellular therapeutics

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12 December 2020

Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells

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12 December 2020

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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12 December 2020

B-cell receptor and Fas-mediated signals for life and death

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12 December 2020

Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans

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12 December 2020

Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha

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12 December 2020

Design of antisense oligonucleotides stabilized by locked nucleic acids

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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12 December 2020

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

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12 December 2020

Stem cell medicine encounters the immune system

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12 December 2020

Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes

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12 December 2020

Effects of specific antisense oligonucleotide inhibition of Fas expression on T cell apoptosis induced by Fas ligand

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12 December 2020

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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12 December 2020

Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo

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12 December 2020

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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12 December 2020

Targeted mRNA degradation by double-stranded RNA in vitro

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12 December 2020

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

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12 December 2020

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

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12 December 2020

RNA catalytic properties of the minimum (-)sTRSV sequence

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12 December 2020

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

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12 December 2020

Nuclear reprogramming: a key to stem cell function in regenerative medicine

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12 December 2020

Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome.

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12 December 2020

Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.

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12 December 2020

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells

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12 December 2020

Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery

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12 December 2020

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

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12 December 2020

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

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12 December 2020

Nitric oxide and its role in apoptosis

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12 December 2020

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

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12 December 2020

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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12 December 2020

Gene targeting by ribozyme against TNF-alpha mRNA inhibits autoimmune arthritis

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12 December 2020

Phospholamban ablation by RNA interference increases Ca2+ uptake into rat cardiac myocyte sarcoplasmic reticulum

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12 December 2020

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

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12 December 2020

Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium

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12 December 2020

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12 December 2020

iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis

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12 December 2020

Chemically modified ribozyme targeting TNF-alpha mRNA regulates TNF-alpha and IL-6 synthesis in synovial fibroblasts of patients with rheumatoid arthritis

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12 December 2020

Regeneration beyond the glial scar

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

IMT504, the prototype of the immunostimulatory oligonucleotides of the PyNTTTTGT class, increases the number of progenitors of mesenchymal stem cells both in vitro and in vivo: potential use in tissue repair therapy

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12 December 2020

The molecular biology of hepatitis delta virus

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12 December 2020

Ribozymes: applications to functional analysis and gene discovery.

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12 December 2020

Gene therapy: applications and progress towards the clinic.

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12 December 2020

Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstruction

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12 December 2020

A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes

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12 December 2020

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

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12 December 2020

Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue

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12 December 2020

The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells.

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12 December 2020

Wound repair and regeneration

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12 December 2020

Initiator caspases in apoptosis signaling pathways

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12 December 2020

Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats

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12 December 2020

Antisense oligonucleotide targeting TNF-alpha can suppress Co-Cr-Mo particle-induced osteolysis

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12 December 2020

The old and the new in p53 functional regulation.

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12 December 2020

Chondrogenic differentiation of human embryonic stem cells: the effect of the micro-environment

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12 December 2020

siRNAs knock down hepatitis

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12 December 2020

PKC-alpha regulates cardiac contractility and propensity toward heart failure

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12 December 2020

Modulation of collagen synthesis in keloid fibroblasts by silencing Smad2 with siRNA.

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12 December 2020

Basic principles of using antisense oligonucleotides in vivo

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12 December 2020

Independent transfer of mitochondrial chromosomes and plasmids during unstable vegetative fusion in Neurospora

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12 December 2020

State-of-the-art tissue engineering: from tissue engineering to organ building

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12 December 2020

A cassette system to study embryonic stem cell differentiation by inducible RNA interference

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12 December 2020

Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes

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12 December 2020

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

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12 December 2020

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance

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12 December 2020

Antisense-oligonucleotide therapy

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12 December 2020

RNAi in arthritis: prospects of a future antisense therapy in inflammation.

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12 December 2020

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

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12 December 2020

Gene therapy for peripheral nervous system diseases

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12 December 2020

Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model

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12 December 2020

Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates

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12 December 2020

Pharmacological approaches to regenerative strategies for the treatment of cardiovascular diseases.

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12 December 2020

A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivo

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12 December 2020

Inhibition of Smad3 expression decreases collagen synthesis in keloid disease fibroblasts.

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12 December 2020

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

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12 December 2020

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology

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12 December 2020

Inhibition of Fas-mediated apoptosis in mouse insulinoma betaTC-3 cells via an anti-Fas ribozyme

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12 December 2020

Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts

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12 December 2020

Inhibition of intercellular adhesion molecule-1 with antisense deoxynucleotides prolongs renal isograft survival in the rat.

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12 December 2020

Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts

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12 December 2020

Reduction in Gsalpha induces osteogenic differentiation in human mesenchymal stem cells.

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12 December 2020

Enhanced intracellular availability and survival of hammerhead ribozymes increases target ablation in a cellular model of osteogenesis imperfecta

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12 December 2020

Small interference RNA against PTP-1B reduces hypoxia/reoxygenation induced apoptosis of rat cardiomyocytes

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12 December 2020

Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue

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12 December 2020

Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A

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12 December 2020

In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.

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12 December 2020

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

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12 December 2020

Short-term and long-term modulation of gene expression by antisense therapeutics

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12 December 2020

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

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12 December 2020

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

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12 December 2020

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

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12 December 2020

Live and let die: regulatory mechanisms in Fas-mediated apoptosis.

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12 December 2020

Progress and potential for regenerative medicine

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?

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12 December 2020

Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications.

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12 December 2020

10.1007/S11095-008-9772-3

Identifiers

DOI

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19 August 2017

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