Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. (Q37572741)

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scientific article published on January 2009

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English	Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.	scientific article published on January 2009

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scholarly article

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4 February 2020

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Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators (English)

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4 February 2020

Alzheimer's disease

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Francesco Panza

1

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4 February 2020

Vincenza Frisardi

3

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4 February 2020

9

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4 February 2020

Vincenzo Solfrizzi

2

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Vincenzo Solfrizzi

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4 February 2020

Alessia D'Introno

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Alessia D'Introno

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4 February 2020

Anna M Colacicco

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Anna M Colacicco

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4 February 2020

Gianluigi Vendemiale

7

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Gianluigi Vendemiale

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4 February 2020

Antonio Capurso

8

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Antonio Capurso

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4 February 2020

Cristiano Capurso

4

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Cristiano Capurso

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publication date

1 January 2009

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4 February 2020

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4 February 2020

26

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4 February 2020

7

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4 February 2020

537-555

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4 February 2020

https://scigraph.springernature.com/pub.10.2165/11315770-000000000-00000

0 references

Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

Neuropathology of cognitively normal elderly.

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

Current Epidemiology of Mild Cognitive Impairment and Other Predementia Syndromes

1 reference

https://api.crossref.org/works/10.2165%2F11315770-000000000-00000

21 January 2018

Progress toward a practical BACE-1 inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memapsin 2 (beta-secretase) inhibitors: drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current epidemiology of mild cognitive impairment and other predementia syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Notch pathway: hair graying and pigment cell homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective loss of central cholinergic neurons in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecule of the month

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch and the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment for MCI: is the evidence sufficient?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta in Alzheimer Disease: The Null versus the Alternate Hypotheses

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The non-amyloidogenic pathway: structure and function of alpha-secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen-containing hormone therapy and Alzheimer's disease risk: understanding discrepant inferences from observational and experimental research

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAMs family members as amyloid precursor protein alpha-secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential for BACE1 inhibitors in the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic potential of gamma-secretase inhibitors and modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate-targeting gamma-secretase modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin reduces caspase-3 activity and up-regulates alpha-secretase in human neuroblastoma SH-SY5Y cells exposed to A beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of intramolecular activation of pepsinogen. Evidence for an intermediate delta and the involvement of the active site of pepsin in the intramolecular activation of pepsinogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological markers associated with normal aging and dementia in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Worldwide variation in the doubling time of Alzheimer's disease incidence rates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase modulation and its promise for Alzheimer's disease: a medicinal chemistry perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid metabolism in cognitive decline and dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial. The Donepezil Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea catechins as a BACE1 (β-Secretase) inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease pathology as a host response

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are not required for A beta 42 production in the early secretory pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition and modulation of gamma-secretase for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent progress in the medicinal chemistry of gamma-secretase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential role of non-steroidal anti-inflammatory drugs in treating Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta immunisation for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase: structure, function, and modulation for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct regulation of intestinal fate by Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta: the alternate hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive frailty: Predementia syndrome and vascular risk factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta40 promotes neuronal cell fate in neural progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of betaAPP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between dementia and nutrition-related factors and disorders: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tarenflurbil: a shot on goal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease-modifying therapies in Alzheimer's disease: how far have we come?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Secretase as a therapeutic target for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One hundred years after the discovery of Alzheimer's disease. A turning point for therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19655822

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/11315770-000000000-00000

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19655822%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19655822%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

ResearchGate publication ID

0 references

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