The regulation of protein synthesis in cancer (Q37726457)

22 August 2017

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title

The regulation of protein synthesis in cancer (English)

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22 August 2017

Rafael Cuesta

1

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22 August 2017

Malavika Gupta

series ordinal

2

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22 August 2017

Robert J Schneider

series ordinal

3

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22 August 2017

language of work or name

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27 October 2009

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Progress in Molecular Biology and Translational Science

22 August 2017

published in

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22 August 2017

volume

90

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22 August 2017

page(s)

255-292

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Changes in RNA in relation to growth of the fibroblast. IV. Alterations in theproduction and processing of mRNA and rRNA in resting and growing cells

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The effect of protein degradation on cellular growth characteristics

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

What is the restriction point?

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Transformed cells have lost control of ribosome number through their growth cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A hierarchy of ATP-consuming processes in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Structural and functional features of eukaryotic mRNA untranslated regions

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

eIF-4E expression and its role in malignancies and metastases.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The proto-oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Targeting the eukaryotic translation initiation factor 4E for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

eIF4E, the mRNA cap-binding protein: from basic discovery to translational research

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translational control: a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Ras mediates translation initiation factor 4E-induced malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Reduction of translation initiation factor 4E decreases the malignancy of ras -transformed cloned rat embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Autoantibody signatures in prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of p150 in cervical neoplasia and its potential value in predicting survival

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Identification of a 170-kDa protein over-expressed in lung cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

p150 expression and its prognostic value in squamous-cell carcinoma of the esophagus

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

p150 overexpression in gastric carcinoma: the association with p53, apoptosis and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

EIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c)

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Loss of the eukaryotic initiation factor 3f in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Loss of the eukaryotic initiation factor 3f in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

eIF2 and the control of cell physiology

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translational control in the endoplasmic reticulum stress response

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulated translation initiation controls stress-induced gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of the double-stranded RNA-dependent protein kinase (p68) in squamous cell carcinoma of the head and neck region

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Correlation of the expression of double-stranded RNA-dependent protein kinase (p68) with differentiation in head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Interferon-responsive protein kinase (p68) and proliferating cell nuclear antigen are inversely distributed in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Protein expression of double-stranded RNA-activated protein kinase in thyroid carcinomas: correlations with histologic types, pathologic parameters, and Ki-67 labeling

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of the double-stranded RNA-dependent protein kinase (p68) in human breast tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Eukaryotic initiation factors (eIF) 2alpha and 4E expression, localization, and phosphorylation in brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia and regulation of messenger RNA translation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia signalling through mTOR and the unfolded protein response in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

To be or not to be in the nucleolus

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Pre-ribosomes on the road from the nucleolus to the cytoplasm

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Nucleolar size indicates the rapidity of cell proliferation in cancer tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of Mammalian Ribosomal Gene Transcription by RNA Polymerase I

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Cell cycle-dependent regulation of RNA polymerase I transcription: the nucleolar transcription factor UBF is inactive in mitosis and early G1.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Cell-cycle-dependent translational control

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

In vivo release of mitotic silencing of ribosomal gene transcription does not give rise to precursor ribosomal RNA processing

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

G1 events and regulation of cell proliferation

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https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translocations involving c-myc and c-myc function

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

An encore for ribosome biogenesis in the control of cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Principles of tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

p53 in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Repression of RNA polymerase I transcription by the tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mechanism of Repression of RNA Polymerase I Transcription by the Retinoblastoma Protein

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The Rb/E2F pathway: expanding roles and emerging paradigms

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

1 reference

7 January 2021

Altered cellular responses by varying expression of a ribosomal protein gene: sequential coordination of enhancement and suppression of ribosomal protein S3a gene expression induces apoptosis

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https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Aberrant Regulation of Translation Initiation in Tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The implications of structured 5' untranslated regions on translation and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translational control of growth factor and proto-oncogene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.

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https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

p53-independent activities of MDM2 and their relevance to cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

MDM2 is a central node in the p53 pathway: 12 years and counting

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Role of two upstream open reading frames in the translational control of oncogene mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Cancer Incidence in BRCA1 mutation carriers

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Structural determinants of BRCA1 translational regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Identification of novel RARbeta2 transcript variants with short 5'-UTRs in normal and cancerous breast epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Distribution and effects of nonsense polymorphisms in human genes

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The complex relationship between BRCA1 and ERalpha in hereditary breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A somatic mutation in the 5'UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The regulation of INK4/ARF in cancer and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Thymidylate synthase pharmacogenetics

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Targeting translation for treatment of cancer--a novel role for IRES?

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Impact of XIAP protein levels on the survival of myeloma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

MicroRNAs: target recognition and regulatory functions

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

PI3K inhibitors for cancer treatment: where do we stand?

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

PI3K/Akt: getting it right matters

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Ras, PI(3)K and mTOR signalling controls tumour cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

ErbB receptors and signaling pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

PTEN: a new guardian of the genome.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Targeting mTOR with rapamycin: one dose does not fit all

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

PRAS40 deregulates apoptosis in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Comparison of Akt/mTOR signaling in primary breast tumors and matched distant metastases

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

S6K1 plays a key role in glial transformation

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Modelling oncogenic Ras/Raf signalling in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Dissecting eIF4E action in tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of autophagy through multiple independent hypoxic signaling pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia-induced energy stress regulates mRNA translation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Hypoxia-inducible factors: central regulators of the tumor phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Translational control in stress and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

The molecular mechanisms that underlie the tumor suppressor function of LKB1.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

Activating transcription factor 4.

1 reference

https://api.crossref.org/works/10.1016%2FS1877-1173%2809%2990007-2

7 January 2021

10.1016/S1877-1173(09)90007-2

Identifiers

DOI

1 reference

22 August 2017

1 reference