Silencing of CDK5 as potential therapy for Alzheimer's disease (Q37863144)

24 August 2017

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title

Silencing of CDK5 as potential therapy for Alzheimer's disease (English)

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Gloria Patricia Cardona-Gomez

24 August 2017

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6

object named as

Gloria Patricia Cardona-Gómez

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24 August 2017

Alejandro López-Tobón

1

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24 August 2017

John Fredy Castro-Álvarez

2

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24 August 2017

Diego Piedrahita

3

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24 August 2017

Ryan L Boudreau

4

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24 August 2017

Juan Carlos Gallego-Gómez

5

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24 August 2017

1 January 2011

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Reviews in the Neurosciences

24 August 2017

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24 August 2017

22

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24 August 2017

2

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24 August 2017

143-152

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Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

24 August 2017

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Controlled and localized genetic manipulation in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

GSK-3 inhibitors for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Role of tau protein in both physiological and pathological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

RNAi therapeutics for CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

The roles of cyclin-dependent kinase 5 in dendrite and synapse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Viral vectors for gene delivery to the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cdk5: a novel role in learning and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

GSK-3: a key player in neurodegeneration and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Retinal and peripheral nerve toxicity induced by the administration of a pan-cyclin dependent kinase (cdk) inhibitor in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Mechanisms of tau-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Designer gene delivery vectors: molecular engineering and evolution of adeno-associated viral vectors for enhanced gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cdk5 is essential for adult hippocampal neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regulation of NMDA receptors by cyclin-dependent kinase-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Gene therapy: promises and problems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Association of neurofilament proteins with neuronal Cdk5 activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Gastric and pancreatic lesions in rats treated with a pan-CDK inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Viral-based modelling and correction of neurodegenerative diseases by RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

A hippocampal Cdk5 pathway regulates extinction of contextual fear

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Gene therapy: twenty-first century medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FRNS.2011.015

21 January 2018

Identifiers

DOI

10.1515/RNS.2011.015

1 reference

24 August 2017

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