Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice (Q37928941)

25 August 2017

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title

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice (English)

1 reference

25 August 2017

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1 reference

Giada Sebastiani

1

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PubMed ID

21901209

25 August 2017

Kostas Pantopoulos

series ordinal

2

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25 August 2017

7 September 2011

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25 August 2017

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25 August 2017

3

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25 August 2017

10

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25 August 2017

971-986

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Chemistry and biology of eukaryotic iron metabolism

25 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Role of free radicals and catalytic metal ions in human disease: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Regulation of iron acquisition and storage: consequences for iron-linked disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Two to tango: regulation of Mammalian iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

An iron-regulated ferric reductase associated with the absorption of dietary iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Unexpected role of ceruloplasmin in intestinal iron absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Ferritins: a family of molecules for iron storage, antioxidation and more.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mitoferrin is essential for erythroid iron assimilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Function and biogenesis of iron-sulphur proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

IscA, an alternate scaffold for Fe-S cluster biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Cysteine desulfurase activity indicates a role for NIFS in metallocluster biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Frataxin and mitochondrial FeS cluster biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

ER stress controls iron metabolism through induction of hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Regulation of cellular iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The distal location of the iron responsive region of the hepcidin promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Control of iron homeostasis by an iron-regulated ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Nutritional iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Interleukin-6 induces hepcidin expression through STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Anemia of chronic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron availability and infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron metabolism in the anemia of chronic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The anaemia of cancer: death by a thousand cuts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron supplementation to treat anemia in patients with chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The serine protease TMPRSS6 is required to sense iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepcidin and disorders of iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Non-transferrin bound iron: a key role in iron overload and iron toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron, hemochromatosis, and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-induced oxidant stress in alcoholic liver fibrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Disorders of iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hereditary hemochromatosis--a new look at an old disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hemochromatosis: genetics and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Stimulation of an unfolded protein response impairs MHC class I expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-overload-related disease in HFE hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Regulation of hepcidin and iron-overload disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron storage disease: facts, fiction and progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

HFE gene knockout produces mouse model of hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Genes that modify the hemochromatosis phenotype in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Multigenic control of hepatic iron loading in a murine model of hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hfe acts in hepatocytes to prevent hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Function of the hemochromatosis protein HFE: Lessons from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Juvenile hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Juvenile hemochromatosis locus maps to chromosome 1q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A mouse model of juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

Non-HFE haemochromatosis

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepcidin is decreased in TFR2 hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

The ferroportin disease

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepcidin in iron overload disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The molecular basis of ferroportin-linked hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The copper-iron connection: hereditary aceruloplasminemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation: administration of fresh-frozen human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Heme oxygenase 1 is required for mammalian iron reutilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Reduced stress defense in heme oxygenase 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The pathogenesis of Friedreich ataxia and the structure and function of frataxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Selective iron chelation in Friedreich ataxia: biologic and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron, brain ageing and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Genetics of neurodegeneration with brain iron accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Pathogenesis of hyperferritinemia cataract syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Clinical severity and thermodynamic effects of iron-responsive element mutations in hereditary hyperferritinemia-cataract syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron chelator research: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease: the role of natural and synthetic chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Design of clinically useful iron(III)-selective chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Combined therapy with deferoxamine and deferiprone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron overload in HFE-related hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron in nonhemochromatotic liver disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The global burden of hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Elevated hepatic iron: a confounding factor in chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron and chronic viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Reduced serum hepcidin levels in patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Changes in serum iron levels due to infection with hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Serum ferritin as a predictor of host response to hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatic iron overload is common in chronic hepatitis B and is more severe in patients coinfected with hepatitis D virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron as a co-morbid factor in nonhemochromatotic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Role of alcohol in the regulation of iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Risk factors of fibrosis in alcohol-induced liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

NASH: A global health problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Insulin resistance-associated hepatic iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatic iron and nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatic iron loading in mice increases cholesterol biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Immunoreactive uroporphyrinogen decarboxylase in the liver in porphyria cutanea tarda

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Down-regulation of hepcidin in porphyria cutanea tarda

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

Juvenile hemochromatosis locus maps to chromosome 1q in a French Canadian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

IscU as a Scaffold for Iron−Sulfur Cluster Biosynthesis: Sequential Assembly of [2Fe-2S] and [4Fe-4S] Clusters in IscU†

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00082A

21 January 2018

Identifiers

DOI

10.1039/C1MT00082A

1 reference

release_u76n26wbvbgrplbrcnkgufs4ke

25 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u76n26wbvbgrplbrcnkgufs4ke

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

21901209

1 reference

PubMed ID

21901209