Rare insights into cancer biology (Q38118122)

29 August 2017

title

Rare insights into cancer biology (English)

1 reference

29 August 2017

J Adam

1

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author name string

M Yang

series ordinal

2

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29 August 2017

T Soga

series ordinal

3

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29 August 2017

P J Pollard

series ordinal

4

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29 August 2017

language of work or name

English

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publication date

1 July 2013

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29 August 2017

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29 August 2017

volume

33

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29 August 2017

issue

20

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29 August 2017

page(s)

2547-2556

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On the Origin of Cancer Cells

29 August 2017

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UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

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Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma

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The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia

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A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

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Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

21 January 2018

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

21 January 2018

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Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

21 January 2018

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Quantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry

21 January 2018

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Journeys into the genome of cancer cells

21 January 2018

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Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

21 January 2018

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Mutation and cancer: statistical study of retinoblastoma

21 January 2018

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Mitochondrial tumour suppressors: a genetic and biochemical update

21 January 2018

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

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21 January 2018

SDH mutations in cancer

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Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

21 January 2018

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21 January 2018

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Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

21 January 2018

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SDHA is a tumor suppressor gene causing paraganglioma

21 January 2018

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SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

21 January 2018

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Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

21 January 2018

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Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

21 January 2018

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Germline SDHB mutations and familial renal cell carcinoma.

21 January 2018

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Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

21 January 2018

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SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes

21 January 2018

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Untuning the tumor metabolic machine: HIF-α: pro- and antitumorigenic?

21 January 2018

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

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Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions

21 January 2018

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

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Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas

21 January 2018

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A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

21 January 2018

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The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

21 January 2018

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SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling

21 January 2018

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Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis.

21 January 2018

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The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.

21 January 2018

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Histone lysine demethylases: emerging roles in development, physiology and disease

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

The TET family of proteins: functions and roles in disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

CpG island methylator phenotype in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

IDH1 and IDH2 mutations in gliomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

21 January 2018

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Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation

21 January 2018

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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

21 January 2018

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Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

21 January 2018

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.222

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

21 January 2018

1 reference

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Fumarase: a paradigm of dual targeting and dual localized functions

21 January 2018

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Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Inherited susceptibility to uterine leiomyomas and renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Cancer. Puzzling patterns of predisposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

The emerging role of fumarate as an oncometabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Increased risk of cancer in patients with fumarate hydratase germline mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Succination of proteins in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Succination of proteins by fumarate: mechanism of inactivation of glyceraldehyde-3-phosphate dehydrogenase in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes: formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Mechanistic studies of the Nrf2-Keap1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Synthetic lethality: a framework for the development of wiser cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Harnessing transposons for cancer gene discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Specific PET imaging of xC- transporter activity using a ¹⁸F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Fumarate Hydratase Deficiency and Cancer: Activation of Hypoxia Signaling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Choline metabolism in malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Metabolomic profiling of anionic metabolites by capillary electrophoresis mass spectrometry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

SDHA Immunohistochemistry Detects GermlineSDHAGene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

The purine nucleotide cycle activity in renal cortex and medulla

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Renal arginine metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Urea biosynthesis I. The urea cycle and relationships to the citric acid cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.222

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.222

1 reference

Dimensions Publication ID

29 August 2017

1033110397

0 references

1 reference