Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles? (Q38230277)

31 August 2017

Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles? (English)

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31 August 2017

R Sapir-Koren

1

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31 August 2017

G Livshits

series ordinal

2

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31 August 2017

language of work or name

English

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publication date

17 July 2014

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Osteoporosis International

31 August 2017

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31 August 2017

25

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31 August 2017

12

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31 August 2017

2685-2700

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https://scigraph.springernature.com/pub.10.1007/s00198-014-2808-0

31 August 2017

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An evolutionary Wolff's law for trabecular architecture

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Osteocyte: the unrecognized side of bone tissue

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Mechanosensation and transduction in osteocytes.

21 January 2018

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DNA methylation contributes to the regulation of sclerostin expression in human osteocytes.

21 January 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

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Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

21 January 2018

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Targeted deletion of Sost distal enhancer increases bone formation and bone mass

21 January 2018

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

21 January 2018

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Targeting sclerostin as potential treatment of osteoporosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

21 January 2018

The amazing osteocyte

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Inhibition of MEPE cleavage by Phex.

21 January 2018

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Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

21 January 2018

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Pathogenic role of Fgf23 in Hyp mice.

21 January 2018

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Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

NF-kappaB modulators in osteolytic bone diseases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Matrix-embedded cells control osteoclast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

MLO-Y4 osteocyte-like cells support osteoclast formation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Dissociation between bone resorption and bone formation in osteopenic transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Commitment to the osteoblast lineage is not required for RANKL gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Osteocyte RANKL: new insights into the control of bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

The Wnt signaling pathway in development and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Roles of Wnt signals in bone resorption during physiological and pathological states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Lrp5 functions in bone to regulate bone mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Essential role of beta-catenin in postnatal bone acquisition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Osteocytes, mechanosensing and Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

WNT signaling in bone homeostasis and disease: from human mutations to treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin: current knowledge and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Phosphate/pyrophosphate and MV-related proteins in mineralisation: discoveries from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

An integrated understanding of the physiological response to elevated extracellular phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Effects of extracellular phosphate on gene expression in murine osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) Expression in Osteocytes In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Early chronic kidney disease-mineral bone disorder stimulates vascular calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Is Wnt signalling the final common pathway leading to bone formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Regulation of circulating sclerostin levels by sex steroids in women and in men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

TNF-α mediates the stimulation of sclerostin expression in an estrogen-deficient condition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Control of the SOST bone enhancer by PTH using MEF2 transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Local bone formation due to combined mechanical loading and intermittent hPTH-(1-34) treatment and its correlation to mechanical signal distributions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

The sclerostin-bone protein interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Is BMU-coupling a strain-regulated phenomenon? A finite element analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

In Vivo Tracer Transport Through the Lacunocanalicular System of Rat Bone in an Environment Devoid of Mechanical Loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00198-014-2808-0

Increased intracortical remodeling following fatigue damage

21 January 2018

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12 December 2020

Evidence for the role of osteocytes in the initiation of targeted remodeling

1 reference

12 December 2020

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

1 reference

12 December 2020

Microdamage and osteocyte-lacuna strain in bone: a microstructural finite element analysis

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12 December 2020

Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women

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12 December 2020

The osteocyte: an endocrine cell ... and more

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12 December 2020

Targeting the RANK/RANKL/OPG signaling pathway: a novel approach in the management of osteoporosis

1 reference

12 December 2020

DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix.

1 reference

12 December 2020

One mechanostat or many? Modifications of the site-specific response of bone to mechanical loading by nature and nurture

1 reference

12 December 2020

Emerging drugs for postmenopausal osteoporosis

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12 December 2020

Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss

1 reference

12 December 2020

Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community

1 reference

12 December 2020

Bone matrix quality after sclerostin antibody treatment

1 reference

12 December 2020

A sclerostin-based theory for strain-induced bone formation

1 reference

12 December 2020

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

12 December 2020

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

1 reference

12 December 2020

10.1007/S00198-014-2808-0

Identifiers

DOI

1 reference

Dimensions Publication ID

31 August 2017

0 references

1 reference