Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications. (Q38648760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

2 references

31 October 2020

30 January 2021

Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

31 October 2020

1 reference

prolyl-hydroxylase inhibitors

1 reference

30 January 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Eun Gyeong Yang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

language of work or name

English

0 references

publication date

19 November 2015

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

31 October 2020

30 January 2021

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

31 October 2020

30 January 2021

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

20551-20568

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

1 March 2020

copyright license

2 references

31 October 2020

30 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

PHD3 regulates EGFR internalization and signalling in tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A lactate-induced response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

In vivo functions of the prolyl-4-hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF pathway mutations and erythrocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF-1alpha peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Assay for 2-oxoglutarate decarboxylating enzymes based on the determination of [1-14C]succinate: application to prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Effect of proline analogues on activity of human prolyl hydroxylase and the regulation of HIF signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A fluorescence polarization-based interaction assay for hypoxia-inducible factor prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

A novel prolyl hydroxylase inhibitor protects against cell death after hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Reactivation of hepatic EPO synthesis in mice after PHD loss

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF prolyl hydroxylase inhibitors for anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Myocardial ischemia-reperfusion injury: a neglected therapeutic target.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

21 January 2018

Hypoxia and inflammation

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Hypoxia and inflammation are two sides of the same coin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF-1alpha dysfunction in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Prolyl 4-hydroxylases, master regulators of the hypoxia response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES201119717

HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases

21 January 2018

1 reference

12 December 2020

Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

12 December 2020

Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

1 reference

12 December 2020

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

1 reference

12 December 2020

Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein

1 reference

12 December 2020

Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation

1 reference

12 December 2020

10 Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes

1 reference

12 December 2020

10.3390/MOLECULES201119717

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26610437%20AND%20SRC:MED&resulttype=core&format=json