Prolyl 4-hydroxylases, master regulators of the hypoxia response (Q38089239)

28 August 2017

title

Prolyl 4-hydroxylases, master regulators of the hypoxia response (English)

1 reference

28 August 2017

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J Myllyharju

1

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28 August 2017

language of work or name

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12 April 2013

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28 August 2017

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28 August 2017

volume

208

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28 August 2017

issue

2

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28 August 2017

page(s)

148-165

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Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima

28 August 2017

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice

21 January 2018

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Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice.

21 January 2018

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Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene

21 January 2018

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Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ

21 January 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

21 January 2018

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Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung

21 January 2018

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Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

21 January 2018

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Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia

21 January 2018

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Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen-sensing under the influence of nitric oxide

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

What is so bad about a hemoglobin level of 12 to 13 g/dL for chronic kidney disease patients anyway?

21 January 2018

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https://api.crossref.org/works/10.1111%2FAPHA.12096

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

New agents that stimulate erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The human oxygen sensing machinery and its manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Erythropoietin in cancer patients: pros and cons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

21 January 2018

Hypoxia and inflammation

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The updated biology of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia signaling during intestinal ischemia and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxic regulation of erythropoiesis and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen and iron regulation of iron regulatory protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Short hairpin RNA interference therapy for ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The role of HIF prolyl hydroxylases in tumour growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factors, stem cells, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The active site of an algal prolyl 4-hydroxylase has a large structural plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

PHD2 mutation and congenital erythrocytosis with paraganglioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The HIF pathway and erythrocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

New anemia therapies: translating novel strategies from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factors and the response to hypoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Structural studies on human 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF pathway mutations and erythrocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Reactivation of hepatic EPO synthesis in mice after PHD loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl 4-hydroxylases and their potential as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Collagens, modifying enzymes and their mutations in humans, flies and worms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Extracellular matrix genes as hypoxia-inducible targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Therapeutic manipulation of the HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Interdependence of hypoxic and innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Vitamin C is dispensable for oxygen sensing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Biology of hypoxia-inducible factor-2alpha in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Regulation of angiogenesis by hypoxia: role of the HIF system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Revisiting the TCA cycle: signaling to tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The role of hypoxia-inducible factors in tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Inhibition of 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Adenoviral transfer of HIF-1alpha enhances vascular responses to critical limb ischemia in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen sensing by HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

2-Oxoglutarate oxygenases are inhibited by a range of transition metals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen sensing, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factors in physiology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Gene therapy progress and prospects: therapeutic angiogenesis for ischemic cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Pro- and anti-angiogenic therapy and atherosclerosis with special emphasis on vascular endothelial growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Normoxic destabilization of ATF-4 depends on proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Prolyl hydroxylase 2: a novel regulator of β2 -adrenoceptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FAPHA.12096

21 January 2018

Identifiers

DOI

10.1111/APHA.12096

1 reference

28 August 2017

1 reference