Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease (Q38732972)

5 September 2017

title

Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease (English)

1 reference

5 September 2017

2

Jeffrey A Bluestone

1 reference

5 September 2017

Michel DuPage

1

1 reference

5 September 2017

publication date

15 February 2016

1 reference

Nature Reviews Immunology

5 September 2017

published in

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5 September 2017

volume

16

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5 September 2017

issue

3

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5 September 2017

page(s)

149-163

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Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production

5 September 2017

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Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

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The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.

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Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection

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Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

31 March 2020

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Fate mapping of IL-17-producing T cells in inflammatory responses

31 March 2020

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An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

31 March 2020

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IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection

31 March 2020

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T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines

31 March 2020

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Linking T-cell receptor sequence to functional phenotype at the single-cell level

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

The JAK-STAT pathway: impact on human disease and therapeutic intervention

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2015.18

Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Interleukin-27: balancing protective and pathological immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Phenotypical and functional specialization of FOXP3+ regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Selection of regulatory T cells in the thymus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Functional plasticity of an antigen-specific memory CD4 T cell population.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Continuous requirement for the TCR in regulatory T cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Regulation of T-cell responses by PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

TSC1 regulates the balance between effector and regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The duration of T cell stimulation is a critical determinant of cell fate and plasticity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Fueling immunity: insights into metabolism and lymphocyte function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The CD28 signaling pathway regulates glucose metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Bcl-6 directly represses the gene program of the glycolysis pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Posttranscriptional control of T cell effector function by aerobic glycolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

STATs shape the active enhancer landscape of T cell populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

STAT6-dependent regulation of Th9 development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Transcriptional regulation and its misregulation in disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Helper T cell differentiation is controlled by the cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Histone lysine demethylases as targets for anticancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Dynamic regulation of nucleosome positioning in the human genome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Epigenetics of T cells regulated by Polycomb/Trithorax molecules

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Mbd2 promotes foxp3 demethylation and T-regulatory-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Long noncoding RNA in hematopoiesis and immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cell division curtails helper phenotype plasticity and expedites helper T-cell differentiation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

De novo DNA methylation is required to restrict T helper lineage plasticity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Epigenetic control of immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The polycomb repressive complex 2 governs life and death of peripheral T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Emerging roles for chromatin as a signal integration and storage platform

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

MicroRNA-mediated regulation of T helper cell differentiation and plasticity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Regulatory T cell proliferative potential is impaired in human autoimmune disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

IL-2: Change Structure … Change Function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Releasing the Brakes on Cancer Immunotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Expansion of human regulatory T-cells from patients with type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cell-based therapeutics: the next pillar of medicine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

SIRT1 deacetylates RORγt and enhances Th17 cell generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Role of Blimp-1 in programing Th effector cells into IL-10 producers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Control of TH17 cells occurs in the small intestine.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Diverting T helper cell trafficking through increased plasticity attenuates autoimmune encephalomyelitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Profiles of lymphokine activities and helper function for IgE in human T cell clones

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2015.18

Functional heterogeneity among human inducer T cell clones

31 March 2020

1 reference

12 December 2020

An obligate cell-intrinsic function for CD28 in Tregs

1 reference

12 December 2020

Multiple treg suppressive modules and their adaptability.

1 reference

12 December 2020

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI.2015.18

1 reference

5 September 2017

1 reference