The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy (Q38992751)

8 September 2017

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy (English)

1 reference

8 September 2017

1 reference

GOA release 2020-03-11

protein ubiquitination

1 reference

Tom Cornelissen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852371%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Dominik Haddad

2

1 reference

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4 June 2020

Fieke Wauters

3

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4 June 2020

Cindy Van Humbeeck

4

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4 June 2020

Wim Mandemakers

5

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4 June 2020

Brianada Koentjoro

6

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4 June 2020

Kris Gevaert

8

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4 June 2020

Wim Vandenberghe

11

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4 June 2020

Bart De Strooper

9

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4 June 2020

publication date

22 May 2014

1 reference

8 September 2017

Human Molecular Genetics

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852371%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

volume

23

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4 June 2020

page(s)

5227-5242

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4 June 2020

issue

19

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describes a project that uses

4 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7108632/fullTextXML

inferred from PubMed Central ID database lookup

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

What genetics tells us about the causes and mechanisms of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Parkin interacts with Ambra1 to induce mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Breaking the chains: structure and function of the deubiquitinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The ubiquitin pathway in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Phenotypic variability of parkin mutations in single kindred.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Pathogenic mutations inactivate parkin by distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Systematic analysis of the physiological importance of deubiquitinating enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Aconitase causes iron toxicity in Drosophila pink1 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU244

Ubiquitin is phosphorylated by PINK1 to activate parkin

21 January 2018

1 reference

12 December 2020

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

1 reference

12 December 2020

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries

1 reference

12 December 2020

Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair

1 reference

12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

12 December 2020

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

1 reference

12 December 2020

Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDU244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852371%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852371%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852371%20AND%20SRC:MED&resulttype=core&format=json