Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis. (Q39919544)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18996842%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

title

Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis (English)

1 reference

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26 December 2019

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5

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26 December 2019

author name string

Baukje M Elzinga

1

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26 December 2019

Ciara Twomey

2

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26 December 2019

James C Powell

3

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26 December 2019

Frances Harte

4

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26 December 2019

language of work or name

English

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publication date

7 November 2008

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Journal of Biological Chemistry

26 December 2019

published in

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26 December 2019

volume

284

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26 December 2019

issue

3

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26 December 2019

page(s)

1394-1409

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Toll-like receptor signalling

26 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Toll-like receptors in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The interleukin 1 receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Interleukin-1 receptor antagonist: role in biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Intracellular trafficking of interleukin-1 receptor I requires Tollip

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Neurotrophin-regulated signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Therapeutic benefits from targeting of ADAM family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

ADAMs: key components in EGFR signalling and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

SorLA signaling by regulated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Proteolysis as a regulatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Intramembrane proteolysis: theme and variations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The gamma-secretase complex: machinery for intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Substrate specificity of gamma-secretase and other intramembrane proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Activity of gamma-secretase on substrates other than APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Involvement of presenilins in cell-survival signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Active gamma-secretase complexes contain only one of each component

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Nicastrin: gatekeeper of the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The gamma-secretase complex: membrane-embedded proteolytic ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin function and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Intramembrane proteolysis by presenilin and presenilin-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Defective signal transduction in B lymphocytes lacking presenilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

CD74 is a member of the regulated intramembrane proteolysis-processed protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Mechanism and biological significance of CD44 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Adaptor usage and Toll-like receptor signaling specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Association of the p75 neurotrophin receptor with TRAF6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Distinct molecular mechanism for initiating TRAF6 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Ubiquitination and TRAF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Soluble cytokine receptors in biological therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Regulation of inhibitory pathways of the interleukin-1 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Shedding light on ADAM metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin endoproteolysis is an intramolecular cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

The molecular mechanism of programmed cell death in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Mammalian MAP kinase signalling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Physiological roles of SAPK/JNK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin diversifies its portfolio.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Functions of toll-like receptors: lessons from KO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803108200

21 January 2018

Identifiers

DOI

10.1074/JBC.M803108200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18996842%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference