Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance (Q44328454)

23926267

2 December 2017

title

Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance (English)

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2 December 2017

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10

Xu Shen

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2 December 2017

Zhiyuan Zhu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Jianming Yan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Wei Jiang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Xin-gang Yao

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Jing Chen

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Lili Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Chenjing Li

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Lihong Hu

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Hualiang Jiang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

Xu Shen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

language of work or name

English

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publication date

1 August 2013

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23926267

2 December 2017

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

volume

33

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

issue

32

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15 May 2020

page(s)

13138-13149

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

15 May 2020

cites work

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12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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Autophagy as a regulated pathway of cellular degradation

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PKB/AKT: functional insights from genetic models

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12 December 2020

Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor

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12 December 2020

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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12 December 2020

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

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12 December 2020

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

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12 December 2020

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

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12 December 2020

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

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12 December 2020

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

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12 December 2020

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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12 December 2020

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

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12 December 2020

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

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12 December 2020

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

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12 December 2020

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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12 December 2020

Autophagy fights disease through cellular self-digestion

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Assessment of spatial memory using the radial arm maze and Morris water maze

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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12 December 2020

AMPK and Raptor: matching cell growth to energy supply.

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12 December 2020

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

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12 December 2020

ApoE promotes the proteolytic degradation of Abeta

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12 December 2020

A scientific approach to anti-ageing therapies: state of the art.

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12 December 2020

Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease

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12 December 2020

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

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12 December 2020

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

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12 December 2020

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Autophagy for the avoidance of neurodegeneration

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12 December 2020

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

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12 December 2020

Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity

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12 December 2020

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

1 reference

12 December 2020

2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice

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12 December 2020

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

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12 December 2020

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

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12 December 2020

Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

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12 December 2020

Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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12 December 2020

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism

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12 December 2020

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

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12 December 2020

PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism

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12 December 2020

A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway

1 reference

12 December 2020

Differential regulation of BACE1 expression by oxidative and nitrosative signals

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12 December 2020

Amyloid clearance as a treatment target against Alzheimer's disease.

1 reference

12 December 2020

Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts

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12 December 2020

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

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12 December 2020

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier

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12 December 2020

Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.

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12 December 2020

Arctigenin efficiently enhanced sedentary mice treadmill endurance

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12 December 2020

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway

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12 December 2020

Demonstration of safety in Alzheimer's patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study.

1 reference

12 December 2020

Genes involved in cerebrospinal fluid production as candidate genes for late-onset Alzheimer's disease: a hypothesis

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12 December 2020

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

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12 December 2020

Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice

1 reference

12 December 2020

Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.

1 reference

12 December 2020

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

1 reference

12 December 2020

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

12 December 2020

Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor

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12 December 2020

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism

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12 December 2020

Astrocyte senescence as a component of Alzheimer's disease

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12 December 2020

Chloroquine in cancer therapy: a double-edged sword of autophagy.

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

10.1523/JNEUROSCI.4790-12.2013

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json

15 May 2020

23926267

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6619735&resulttype=core&format=json