Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease (Q81860462)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

review article

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title

Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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3

Kenneth Maiese

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

author name string

Zhao Zhong Chong

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Faqi Li

series ordinal

2

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13 January 2020

publication date

8 January 2005

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13 January 2020

volume

49

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13 January 2020

page(s)

1-21

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13 January 2020

issue

1

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Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons

13 January 2020

cites work

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12 December 2020

Ectopic expression of cell cycle markers in models of induced programmed cell death in dopamine neurons of the rat substantia nigra pars compacta

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12 December 2020

Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways

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12 December 2020

Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

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12 December 2020

Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration

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12 December 2020

Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.

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12 December 2020

Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.

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Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia.

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Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin

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12 December 2020

Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells

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12 December 2020

Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage

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12 December 2020

Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis

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12 December 2020

Light and electron microscopic localization of presenilin-1 in primate brain.

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12 December 2020

Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture

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12 December 2020

Metabotropic glutamate receptor agonists increase release of soluble amyloid precursor protein derivatives from rat brain cortical and hippocampal slices.

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12 December 2020

Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells

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12 December 2020

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

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12 December 2020

The CARD domain: a new apoptotic signalling motif

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12 December 2020

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

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12 December 2020

Restriction of microM-calcium-requiring calpain activation to the plasma membrane in human neuroblastoma cells: evidence for regionalized influence of a calpain activator protein

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12 December 2020

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms.

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12 December 2020

Presenilins are processed by caspase-type proteases.

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12 December 2020

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

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12 December 2020

Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells

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12 December 2020

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

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12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin.

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12 December 2020

On the use of Zn2+ to discriminate endonucleases activated during apoptosis.

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12 December 2020

Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve.

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12 December 2020

Role of calpain and its inhibitors in tissue degeneration and neuroprotection in spinal cord injury

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12 December 2020

Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6.

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12 December 2020

Regulation of apoptosis by BH3 domains in a cell-free system

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12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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12 December 2020

Metabotropic glutamate receptors prevent nitric oxide-induced programmed cell death

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12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

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12 December 2020

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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12 December 2020

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

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12 December 2020

The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death

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12 December 2020

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants

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12 December 2020

Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1

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12 December 2020

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

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12 December 2020

Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease

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12 December 2020

Modulated expression of secreted frizzled-related proteins in human retinal degeneration.

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12 December 2020

Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death.

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12 December 2020

Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription

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12 December 2020

Proapoptotic effects of tau cleavage product generated by caspase-3.

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12 December 2020

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

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12 December 2020

Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts

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12 December 2020

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

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12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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12 December 2020

A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neurons

1 reference

12 December 2020

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

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12 December 2020

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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12 December 2020

WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.

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12 December 2020

The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells

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12 December 2020

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival

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12 December 2020

The dynamics of cellular injury: transformation into neuronal and vascular protection

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12 December 2020

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

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12 December 2020

Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.

1 reference

12 December 2020

The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides

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12 December 2020

Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways

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12 December 2020

Regulation of endothelial cell death and its role in angiogenesis and vascular regression.

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12 December 2020

Abnormalities of peptide metabolism in Alzheimer disease

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12 December 2020

Apoptosis: a key in neurodegenerative disorders

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12 December 2020

Calcium homeostasis following traumatic neuronal injury

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12 December 2020

Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

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12 December 2020

Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease

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12 December 2020

Anti-apoptotic proteins are oxidized by Abeta25-35 in Alzheimer's fibroblasts.

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12 December 2020

Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

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12 December 2020

Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease.

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12 December 2020

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity.

1 reference

12 December 2020

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

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12 December 2020

Memantine in moderate-to-severe Alzheimer's disease

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12 December 2020

Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways

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12 December 2020

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

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12 December 2020

Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

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12 December 2020

Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner

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12 December 2020

Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis

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12 December 2020

The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process

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12 December 2020

Oxidative neurotoxicity in rat cerebral cortex neurons: Synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen‐activated protein kinase and caspase‐3

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12 December 2020

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

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12 December 2020

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

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12 December 2020

The Wnt signaling pathway and its role in tumor development

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12 December 2020

Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain

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12 December 2020

Erythropoietin: cytoprotection in vascular and neuronal cells

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12 December 2020

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

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12 December 2020

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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12 December 2020

Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein.

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12 December 2020

Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity

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12 December 2020

A Ca(2+) switch aligns the active site of calpain

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12 December 2020

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis

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12 December 2020

Kinetics of apoptotic markers in exogeneously induced apoptosis of EL4 cells.

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12 December 2020

Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury

1 reference

12 December 2020

PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis

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12 December 2020

Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells

1 reference

12 December 2020

Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

1 reference

12 December 2020

Intracellular calcium level required for calpain activation in a single myocardial cell

1 reference

12 December 2020

Endothelial apoptosis induced by oxidative stress through activation of NF-kappaB: antiapoptotic effect of antioxidant agents on endothelial cells

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12 December 2020

Reactive carbonyl formation by oxidative and non-oxidative pathways

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12 December 2020

Cyclin-dependent kinase 4 and cyclin D1 are required for excitotoxin-induced neuronal cell death in vivo.

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12 December 2020

In-vivo measurement of activated microglia in dementia

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12 December 2020

Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.

1 reference

12 December 2020

Healthcare utilization and costs in managed care patients with Alzheimer's disease during the last few years of life

1 reference

12 December 2020

Models of progression in AD: predicting disability and costs.

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12 December 2020

Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease

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12 December 2020

Cell cycle induction in post-mitotic neurons proceeds in concert with the initial phase of programmed cell death in rat.

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12 December 2020

Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury

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12 December 2020

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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12 December 2020

Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells

1 reference

12 December 2020

Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis

1 reference

12 December 2020

Neuregulin rescues PC12-ErbB4 cells from cell death induced by H(2)O(2). Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase.

1 reference

12 December 2020

Severity of oxidative stress generates different mechanisms of endothelial cell death.

1 reference

12 December 2020

Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells

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12 December 2020

Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons

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12 December 2020

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

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12 December 2020

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

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12 December 2020

Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia

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12 December 2020

Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.

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12 December 2020

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

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12 December 2020

Nitric oxide and hydroxyl radical-induced retinal lipid peroxidation in vitro

1 reference

12 December 2020

Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases

1 reference

12 December 2020

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

1 reference

12 December 2020

Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

1 reference

12 December 2020

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

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12 December 2020

Role of poly(ADP-ribose) formation in DNA repair

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12 December 2020

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

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12 December 2020

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

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12 December 2020

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

1 reference

12 December 2020

Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis

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12 December 2020

Detection of superoxide production by activated microglia using a sensitive and specific chemiluminescence assay and microglia-mediated PC12h cell death

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12 December 2020

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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12 December 2020

Involvement of DNase II in nuclear degeneration during lens cell differentiation

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12 December 2020

Distribution of mu-calpain proenzyme in the brain and other neural tissues in the rat

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12 December 2020

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

12 December 2020

Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats.

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12 December 2020

Cellular mechanisms of protection by metabotropic glutamate receptors during anoxia and nitric oxide toxicity

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12 December 2020

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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12 December 2020

Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients.

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12 December 2020

Calcium influx is a determining factor of calpain activation and microparticle formation in platelets

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12 December 2020

Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2.

1 reference

12 December 2020

Coenzyme nicotinamide adenine dinucleotide: new therapeutic approach for improving dementia of the Alzheimer type.

1 reference

12 December 2020

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

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12 December 2020

Blockade of metabotropic glutamate receptors protects hippocampal neurons from hypoxia-induced cell death in rat in vivo.

1 reference

12 December 2020

The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons.

1 reference

12 December 2020

Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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12 December 2020

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

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12 December 2020

Activation of calpain precedes morphological alterations during hydrogen peroxide-induced apoptosis in neuronally differentiated mouse embryonal carcinoma P19 cell line

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12 December 2020

Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

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12 December 2020

Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain

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12 December 2020

Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death

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12 December 2020

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.

1 reference

12 December 2020

Calpain regulates actin remodeling during cell spreading

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12 December 2020

Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons

1 reference

12 December 2020

Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway.

1 reference

12 December 2020

WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells

1 reference

12 December 2020

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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12 December 2020

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

12 December 2020

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

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12 December 2020

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

1 reference

12 December 2020

Phagocytic clearance of apoptotic neurons by Microglia/Brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition.

1 reference

12 December 2020

Calpain-PKC inter-relations in mouse hippocampus: a biochemical approach.

1 reference

12 December 2020

Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

1 reference

12 December 2020

Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death.

1 reference

12 December 2020

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

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12 December 2020

Nitric oxide induction of neuronal endonuclease activity in programmed cell death.

1 reference

12 December 2020

Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

1 reference

12 December 2020

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1 reference

12 December 2020

Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases

1 reference

12 December 2020

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.

1 reference

12 December 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

12 December 2020

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

12 December 2020

Direct temporal analysis of apoptosis induction in living adherent neurons.

1 reference

12 December 2020

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

12 December 2020

Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: sequential activation of caspases 8, 3, and 1 in the apoptotic process

1 reference

12 December 2020

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

1 reference

12 December 2020

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

12 December 2020

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1 reference

12 December 2020

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

1 reference

12 December 2020

IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity

1 reference

12 December 2020

Increased expression of Wnt-1 in schizophrenic brains.

1 reference

12 December 2020

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

1 reference

12 December 2020

Implication of calpain in caspase activation during B cell clonal deletion

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12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

1 reference

12 December 2020

Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury

1 reference

12 December 2020

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

1 reference

12 December 2020

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

1 reference

12 December 2020

The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress.

1 reference

12 December 2020

Death receptors: signaling and modulation

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

12 December 2020

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

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12 December 2020

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

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12 December 2020

Bax cleavage is mediated by calpain during drug-induced apoptosis

1 reference

12 December 2020

Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

1 reference

12 December 2020

The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.

1 reference

12 December 2020

Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH.

1 reference

12 December 2020

Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

1 reference

12 December 2020

Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment

1 reference

12 December 2020

Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons

1 reference

12 December 2020

Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease

1 reference

12 December 2020

DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

1 reference

12 December 2020

Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection.

1 reference

12 December 2020

Regulation of caspase expression and apoptosis by adenomatous polyposis coli.

1 reference

12 December 2020

Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation

1 reference

12 December 2020

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

1 reference

12 December 2020

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

1 reference

12 December 2020

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

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12 December 2020

Current treatments for Alzheimer's disease: cholinesterase inhibitors.

1 reference

12 December 2020

Caspase activation in the limbic cortex of subjects with early Alzheimer's disease.

1 reference

12 December 2020

Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity

1 reference

12 December 2020

Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors

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12 December 2020

The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival

1 reference

12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

12 December 2020

Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury

1 reference

12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

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12 December 2020

Phosphatidylserine expression on cell surfaces promotes antibody-dependent aggregation and thrombosis in beta2-glycoprotein I-immune mice

1 reference

12 December 2020

Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.

1 reference

12 December 2020

Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

1 reference

12 December 2020

Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration

1 reference

12 December 2020

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

12 December 2020

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

12 December 2020

Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease

1 reference

12 December 2020

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.

1 reference

12 December 2020

Presenilin-1 is located in rat mitochondria

1 reference

12 December 2020

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

12 December 2020

Fractalkine and fractalkine receptors in human neurons and glial cells

1 reference

12 December 2020

Natural history of mild cognitive impairment in older persons

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12 December 2020

Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

1 reference

12 December 2020

Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells

1 reference

12 December 2020

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

1 reference

12 December 2020

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas

1 reference

12 December 2020

Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

1 reference

12 December 2020

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

1 reference

12 December 2020

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

1 reference

12 December 2020

Hormone therapy and Alzheimer's disease: benefit or harm?

1 reference

12 December 2020

Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system

1 reference

12 December 2020

Therapeutic strategies for Alzheimer's disease based on new molecular mechanisms.

1 reference

12 December 2020

AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9

1 reference

12 December 2020

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

1 reference

12 December 2020

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

1 reference

12 December 2020

Gene regulation and DNA damage in the ageing human brain

1 reference

12 December 2020

The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential

1 reference

12 December 2020

Insights into oxidative stress and potential novel therapeutic targets for Alzheimer disease

1 reference

12 December 2020

Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide

1 reference

12 December 2020

Erythropoietin in the brain: can the promise to protect be fulfilled?

1 reference

12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

12 December 2020

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

12 December 2020

Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.

1 reference

12 December 2020

10.1016/J.BRAINRESREV.2004.11.005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15960984%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference