FBW7-mediated ubiquitination and degradation of KLF5 (Q27010419)

Wang P

series ordinal

2

1 reference

language of work or name

1 reference

26 May 2014

1 reference

World journal of biological chemistry

published in

0 references

volume

5

1 reference

issue

2

1 reference

page(s)

216-23

1 reference

Survivin - biology and potential as a therapeutic target in oncology

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Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function

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Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter

21 March 2017

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21 March 2017

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cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2

21 March 2017

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Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

21 March 2017

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 March 2017

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Function and regulation of cullin-RING ubiquitin ligases

21 March 2017

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Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

21 March 2017

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hCDC4 gene mutations in endometrial cancer

21 March 2017

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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling

21 March 2017

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

21 March 2017

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Mammalian Krüppel-like transcription factors: more than just a pretty finger

21 March 2017

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The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis

21 March 2017

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Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

21 March 2017

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Significance of the transcription factor KLF5 in cardiovascular remodeling

21 March 2017

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The SCF ubiquitin ligase: insights into a molecular machine

21 March 2017

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Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

21 March 2017

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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

21 March 2017

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Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

21 March 2017

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

7 April 2017

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Ubiquitin ligases: cell-cycle control and cancer

7 April 2017

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7 April 2017

The renaissance of GSK3

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Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

7 April 2017

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The ubiquitin-proteasome proteolytic pathway

7 April 2017

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A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α).

7 April 2017

1 reference

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F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Smurf E3 ubiquitin ligases at the cross roads of oncogenesis and tumor suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

28 September 2017

1 reference

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GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.

28 September 2017

1 reference

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Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

28 September 2017

1 reference

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SUMOylation regulates nuclear localization of Krüppel-like factor 5.

28 September 2017

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The amplified WWP1 gene is a potential molecular target in breast cancer

28 September 2017

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Targeting Aurora kinases for the treatment of prostate cancer

28 September 2017

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KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells

28 September 2017

1 reference

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KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line

28 September 2017

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Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

28 September 2017

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The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

GSK3 inhibitors: development and therapeutic potential

28 September 2017

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

28 September 2017

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

28 September 2017

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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

28 September 2017

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Krüppel-like factors: three fingers in many pies

28 September 2017

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

28 September 2017

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The biology of the mammalian Krüppel-like family of transcription factors

28 September 2017

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

28 September 2017

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Ubiquitin: Roles in protein modification and breakdown

28 September 2017

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Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection

28 September 2017

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Transcriptional regulation by the Sp family proteins.

31 May 2018

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Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

A phosphorylation cascade controls the degradation of active SREBP1.

28 November 2018

1 reference

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A core Klf circuitry regulates self-renewal of embryonic stem cells.

28 November 2018

1 reference

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

28 November 2018

1 reference

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Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4050114

Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer.

28 November 2018

1 reference

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Fbxw7 hotspot mutations and human colon cancer: mechanistic insights from new mouse models

28 November 2018

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24921010

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Klf5 is involved in self-renewal of mouse embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24921010