PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling (Q28586625)

GOA release 2020-03-11

Kai Kysenius

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Urmas Arumäe

object named as

Urmas Arumäe

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Henri J. Huttunen

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Henri J. Huttunen

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author name string

Pranuthi Muggalla

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31 January 2017

Kert Mätlik

Cellular and Molecular Life Sciences

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31 January 2017

1 June 2012

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31 January 2017

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31 January 2017

69

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31 January 2017

1903–1916

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31 January 2017

11

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31 January 2017

https://scigraph.springernature.com/pub.10.1007/s00018-012-0977-6

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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

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PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

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The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum

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Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death.

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PACAP up-regulates the expression of apolipoprotein D in 3T3-L1 adipocytes. DRG/3T3-L1 co-cultures study

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An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis.

21 January 2018

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Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

21 January 2018

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Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

21 January 2018

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The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

21 January 2018

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NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development

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The role of apolipoprotein E in Alzheimer's disease

21 January 2018

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No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients

21 January 2018

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Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates

21 January 2018

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c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

21 January 2018

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12 December 2020

PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway

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12 December 2020

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

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12 December 2020

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

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12 December 2020

Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons

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12 December 2020

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

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12 December 2020

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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12 December 2020

Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells.

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12 December 2020